A5017802549- Monoclonal and Polyclonal Antibodies Research
- Glycosylation and Glycoproteins Research
- RNA Interference and Gene Delivery
- CAR-T cell therapy research
- Nanoparticle-Based Drug Delivery
- Immunotherapy and Immune Responses
- Protein purification and stability
- Galectins and Cancer Biology
- Viral Infectious Diseases and Gene Expression in Insects
- Antimicrobial Peptides and Activities
- Angiogenesis and VEGF in Cancer
- Nanoparticles: synthesis and applications
- HER2/EGFR in Cancer Research
- Bacterial biofilms and quorum sensing
- Extracellular vesicles in disease
- Characterization and Applications of Magnetic Nanoparticles
- Advanced biosensing and bioanalysis techniques
- Advanced Drug Delivery Systems
- Graphene and Nanomaterials Applications
- Magnesium Oxide Properties and Applications
- Inhalation and Respiratory Drug Delivery
- MicroRNA in disease regulation
- Optical Polarization and Ellipsometry
- Probiotics and Fermented Foods
- Optical Coherence Tomography Applications
Iran University of Medical Sciences
2014-2024
University of Copenhagen
2010-2019
Tehran University of Medical Sciences
2011-2013
Tarbiat Modares University
2008-2010
The filamentous bacteriophage fd bind a cell target with exquisite specificity through its few copies of display peptides, whereas nanoparticles functionalized hundreds to thousands synthetically generated phage peptides exhibit variable and often-weak binding. We hypothesise that some in hierarchical structure rather than monomeric form recognise their target. Here we show hierarchial forms brain-specific phage-derived peptide (herein as NanoLigand Carriers, NLCs) cerebral endothelial cells...
A microfluidic platform combined with synchrotron small-angle X-ray scattering (SAXS) was used for monitoring the continuous production of multilamellar vesicles (MLVs). Their fast and started to evolve within less than 0.43 s contact between lipids aqueous phase. To obtain nanoparticles a narrow size distribution, it important use modified hydrodynamic flow focusing (HFF) device narrower microchannels those normally SAXS experiments. Monodispersed MLVs as small 160 nm in size,...
Methicillin-resistant Staphylococcus aureus (MRSA) is one of the most common causes surgical infection, and its resistance to numerous conventional antibiotics makes treatment difficult. Although vancomycin often an effective agent for initial therapy MRSA, clinical failure sometimes occurs. Therefore, there urgent need develop better therapies. Here, we prepared some vancomycin-loaded nanoliposomes coupled with anti-staphylococcal protein (lysostaphin) evaluated their in vitro vivo efficacy...
Immunotherapy with redirected T cells that express a chimeric antigen receptor (CAR) is promising prospect in cancer treatment. Most CARs use murine-derived single-chain variable fragments (scFvs) as an targeting moiety, which may lead to host immunogenic responses and engineered cell disappearance. It seems development of less CARs, such composed the camelid domain heavy chain antibodies (VHHs) likely overcome this obstacle. Here, we improved expression VHH-based anti-MUC1 CAR gene...
Introduction: Doxorubicin (DOX ) is a widely used first-line treatment for various cancers but causes toxicity. Targeted drug delivery systems, particularly DOX-encapsulated liposomes, show clinical success and lower The abnormal angiogenesis in high-grade tumors, making it crucial to develop strategies that target this process conjunction with chemotherapy. This study presents an innovative formulation of anti-VEGFR2-functionalized liposomal DOX, designed reduce systemic release, enhance...
Chimeric antigen T cell receptors provide a good approach for adoptive immunotherapy of cancer, especially in the context cancerous cells that fail to express major histocompatibility complex and co-stimulatory molecules. Clinical applications these are limited, mostly due xenogenic origin antibodies, which cause immunogenic reactions. Nanobodies smallest fragments antibodies have great homology human VH low potential. MUC1 is highly attractive immunotherapeutic target owing increased...
Gold-coated superparamagnetic iron oxide nanoparticles (SPIONs) coated with methyl-polyethylene glycol (mPEG) are synthesized and investigated as a magnetic resonance (MR) imaging contrast agent. The mPEG-core@shells characterized by UV-visible spectroscopy, transmission electron microscopy (TEM), dynamic light scattering (DLS), vibrating sample magnetometry (VSM), zeta-potential analysis X-ray diffraction (XRD). In addition, the transverse relaxivity of is measured using 3 T MRI scanner....