A5058920725- Angiogenesis and VEGF in Cancer
- Lipid metabolism and disorders
- Glaucoma and retinal disorders
- Retinal Diseases and Treatments
- Cell Adhesion Molecules Research
- Lymphatic System and Diseases
- Bioinformatics and Genomic Networks
- Lipid metabolism and biosynthesis
- Proteoglycans and glycosaminoglycans research
- Hippo pathway signaling and YAP/TAZ
- Lipid Membrane Structure and Behavior
- Kruppel-like factors research
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Genetic Associations and Epidemiology
- Acute Myeloid Leukemia Research
- Nanoparticle-Based Drug Delivery
- RNA Interference and Gene Delivery
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- Retinal Development and Disorders
- Genetic Mapping and Diversity in Plants and Animals
- Cancer-related molecular mechanisms research
- Coagulation, Bradykinin, Polyphosphates, and Angioedema
Institute for Molecular Medicine Finland
2019-2021
University of Helsinki
2010-2021
Wihuri Research Institute
2016-2020
Angiopoietins regulate vascular homeostasis via the endothelial Tie receptor tyrosine kinases. Angiopoietin-1 (Ang1) supports stabilization Tie2 activation. Angiopoietin-2 (Ang2) functions as a context-dependent agonist/antagonist promoting pathological angiogenesis, permeability and inflammation. Elucidating Ang2-dependent mechanisms of destablization is critical for rational design angiopoietin antagonists that have demonstrated therapeutic efficacy in cancer trials. Here, we report Ang2,...
The angiopoietin/Tie (ANG/Tie) receptor system controls developmental and tumor angiogenesis, inflammatory vascular remodeling, vessel leakage. ANG1 is a Tie2 agonist that promotes stabilization in inflammation sepsis, whereas ANG2 context-dependent or antagonist. A limited understanding of ANG signaling mechanisms the orphan Tie1 has hindered development ANG/Tie-targeted therapeutics. Here, we determined both binding to increases Tie1-Tie2 interactions β1 integrin-dependent manner regulates...
Abstract Understanding genetic architecture of plasma lipidome could provide better insights into lipid metabolism and its link to cardiovascular diseases (CVDs). Here, we perform genome-wide association analyses 141 species (n = 2,181 individuals), followed by phenome-wide scans with 25 CVD related phenotypes 511,700 individuals). We identify 35 lipid-species-associated loci (P <5 ×10 −8 ), 10 which associate risk including five new loci- COL5A1 , GLTPD2 SPTLC3 MBOAT7 GALNT16 (false...
Primary lymphedema is caused by developmental and functional defects of the lymphatic vascular system that result in accumulation protein-rich fluid tissues, resulting edema. The 28 currently known genes causing primary can explain <30% cases. Angiopoietin 1 (ANGPT1) ANGPT2 function via TIE1-TIE2 (tyrosine kinase with immunoglobulin-like epidermal growth factor-like domains 2) receptor complex α5β1 integrin to form an endothelial cell signaling pathway critical for blood vessel formation...