A5022020832- Genetics and Neurodevelopmental Disorders
- Alzheimer's disease research and treatments
- Epigenetics and DNA Methylation
- Autism Spectrum Disorder Research
- Nuclear Receptors and Signaling
- PI3K/AKT/mTOR signaling in cancer
- RNA and protein synthesis mechanisms
- Neuroendocrine regulation and behavior
- Receptor Mechanisms and Signaling
- Parkinson's Disease Mechanisms and Treatments
- Pancreatic function and diabetes
- Ginkgo biloba and Cashew Applications
- RNA regulation and disease
McGill University
2023-2024
Cancer Institute (WIA)
2024
McGill University Health Centre
2022
Institut d'Investigació en Ciències de la Salut Germans Trias i Pujol
2021
Universitat Autònoma de Barcelona
2021
Universitat de Barcelona
2019
Epigenetic alterations are a fundamental pathological hallmark of Alzheimer’s disease (AD). Herein, we show the upregulation G9a and H3K9me2 in brains AD patients. Interestingly, treatment with inhibitor (G9ai) SAMP8 mice reversed high levels rescued cognitive decline. A transcriptional profile analysis after G9ai revealed increased gene expression glia maturation factor β (GMFB) mice. Besides, ChIP-seq inhibition showed enrichment promoters associated neural functions. We observed induction...
The implication of epigenetic mechanisms in Alzheimer's disease (AD) has been demonstrated several studies.UNC0642, a specific and potent inhibitor methyltransferase activity G9a/GLP (G9a-like) complex, was evaluated the 5XFAD mouse model.UNC0642 treatment rescued cognition impairment, reduced DNAmethylation (5-mC), increased hydroxymethylation (5-hmC), decreased di-methylation lysine 9 histone H3 (H3K9me2) levels hippocampus.Increases Nuclear Factor erythroid-2-Related 2 (NRF2), Heme...
mRNA translation initiation plays a critical role in learning and memory. The eIF4F complex, composed of the cap-binding protein eIF4E, ATP-dependent RNA helicase eIF4A, scaffolding eIF4G, is pivotal factor process. eIF4G1, major paralogue three eIF4G family members, indispensable for development, but its function memory unknown. To study eIF4G1 cognition, we used an haploinsufficient (eIF4G1-1D) mouse model. axonal arborization eIF4G1-1D primary hippocampal neurons was significantly...
Fragile X syndrome (FXS) is the most common genetic cause of autism spectrum disorder engendered by transcriptional silencing fragile messenger ribonucleoprotein 1 (
Autism spectrum disorder (ASD) is a neurobiologically complex condition with heterogeneous genetic etiology. Clinically, ASD diagnosed by social communication impairments and restrictive or repetitive behaviors, such as hand flapping lining up objects. These behavioral patterns can be reliably observed in mouse models ASD-linked mutations, making them highly useful tools for studying the underlying cellular molecular mechanisms ASD. Understanding how changes affect neurobiology behaviors...
Lewy body diseases (LBD) including dementia with bodies (DLB) and Parkinson disease (PD) are characterized by alpha-synuclein pathology. DLB is difficult to diagnose peripheral biomarkers urgently needed. Therefore, we analyzed the expression of five gene (SNCA) transcripts, SNCAtv1, SNCAtv2, SNCAtv3, SNCA126, SNCA112, in 45 LBD control temporal cortex samples blood 72 DLB, 59 PD, 54 subjects. The results revealed overexpression SNCAtv1 SNCA112 SNCAtv2 PD cortices. In blood, diminution all...
Abstract Epigenetic alterations are a fundamental pathological hallmark of Alzheimer’s disease (AD). Herein, we uncover the unknown G9a modulation pathways involved in AD, showing upregulation and H3K9me2 brains AD patients. Likewise, treatment with inhibitor SAMP8 mice reversed high levels rescued cognitive decline. Interestingly, transcriptional profile analysis revealed induction neuronal plasticity reduction oxidative stress neuroinflammation; latter being also validated cell cultures....