A5051364438- Laser Applications in Dentistry and Medicine
- Electromagnetic Fields and Biological Effects
- Bacteriophages and microbial interactions
- Probiotics and Fermented Foods
- Gut microbiota and health
- Immune Response and Inflammation
- Congenital Heart Disease Studies
- Antimicrobial Peptides and Activities
- Transgenic Plants and Applications
- Biofield Effects and Biophysics
- IL-33, ST2, and ILC Pathways
- Spaceflight effects on biology
- Escherichia coli research studies
- Infant Nutrition and Health
- Clostridium difficile and Clostridium perfringens research
- Pediatric health and respiratory diseases
- Viral gastroenteritis research and epidemiology
- Protein Hydrolysis and Bioactive Peptides
- Inflammatory Bowel Disease
- Hepatitis B Virus Studies
- Neuroinflammation and Neurodegeneration Mechanisms
- Alzheimer's disease research and treatments
- Tracheal and airway disorders
- Ocular and Laser Science Research
- Hormonal Regulation and Hypertension
Universitat de Barcelona
2014-2024
APC Europe (Spain)
2017-2024
Hospital Universitari Joan XXIII de Tarragona
2006
Innovative Wireless Technologies (United States)
2002
Université de Nîmes
1977-1989
Centre Hospitalier Universitaire de Nîmes
1989
Science et Médecine (France)
1989
Institut Bouisson Bertrand
1988
<b>Objectives:</b> To evaluate late mortality and morbidity after an atrial switch procedure for correction of transposition the great arteries (TGA) to assess predictive factors adverse outcome. <b>Setting:</b> Tertiary referral centre. <b>Design patients:</b> Retrospective follow up study 137 patients surviving hospitalisation TGA (Mustard or Senning) in a single institution divided into two groups (simple complex) depending on presurgical anatomy. Several surgical were evaluated during...
Epigenetic alterations are a fundamental pathological hallmark of Alzheimer’s disease (AD). Herein, we show the upregulation G9a and H3K9me2 in brains AD patients. Interestingly, treatment with inhibitor (G9ai) SAMP8 mice reversed high levels rescued cognitive decline. A transcriptional profile analysis after G9ai revealed increased gene expression glia maturation factor β (GMFB) mice. Besides, ChIP-seq inhibition showed enrichment promoters associated neural functions. We observed induction...
We examined whether oral plasma protein supplements affect the innate immune response in a model of acute lung inflammation. Mice were fed diets supplemented with 8 % spray-dried (SDP) or 2 Ig concentrate (IC) from day 19 (weaning) until 34. The mice challenged intranasal lipopolysaccharide (LPS) at 33 (and killed 24 h later for cytokine and leucocyte analyses) 34 6 determinations). In bronchoalveolar lavage fluid (BALF), LPS increased number leucocytes by twenty-sevenfold, an effect that...
Abstract In animal models of inflammation and in farm animals, dietary inclusion spray-dried porcine plasma (SDP) reduces mucosal inflammation. Here, we study whether these effects could be mediated by changes the intestinal microbiota if are similar to those induced oral antibiotics. Weaned 21-day-old C57BL/6 mice were divided into 3 groups: CTL group, fed control diet; COL administered low doses neomycin colistin; SDP supplemented with 8% SDP. After 14 days, analysis fecal microbiome...
Spray-dried preparations from porcine and bovine plasma can alleviate mucosal inflammation in experimental models improve symptoms patients with enteropathy. In rodents, dietary supplementation spray-dried (SDP) attenuates intestinal improves the epithelial barrier function during induced by Staphylococcus aureus enterotoxin B (SEB). The aim of this study was to discern molecular mechanisms involved anti-inflammatory effects SDP. Male C57BL/6 mice were fed 8% SDP or control diet (based on...
Dietary supplementation with spray-dried porcine plasma (SDP) reduces the Alzheimer’s disease (AD) hallmarks in SAMP8 mice. Since gut microbiota can play a critical role AD progression, we have studied if neuroprotective effects of SDP involve microbiota−gut−brain axis. Experiments were performed on two-month-old mice fed standard diet and six-month-old control or an 8% supplemented for four months. Senescence impaired short- long-term memory, reduced cortical brain-derived neurotrophic...
Type I interferon (IFN) activation and its subsequent effects are important in the response to viral infections. Here we show that human astroviruses (HAstVs), which agents of acute gastroenteritis children, induce a mild delayed IFN upon infecting CaCo-2 cells. Although IFN-β mRNA is detected within infected cells supernatant from antiviral activity against replication other well-known IFN-sensitive viruses, these responses occur at late stages infection once genome has taken place. On...
Dietary supplementation with immunoglobulins from animal plasma has anti-inflammatory effects on intestinal and lung models of acute inflammation. Here, we aimed to establish whether dietary intervention serum-derived bovine immunoglobulin (SBI) can prevent alterations in barrier function a mouse model genetic predisposition inflammatory bowel disease (IBD). Wild-type (WT) mice lacking the mdr1a gene (KO) were fed diets supplemented either SBI (2% wt/wt) or milk proteins (control diet), day...
Antimicrobial resistance (AMR) poses a significant threat to human health. Although vaccines have been developed combat AMR, it has proven challenging associate specific vaccine antigens with AMR. Bacterial plasmids play crucial role in the transmission of Our recent research identified group bacterial (specifically, IncHI plasmids) that encode large molecular mass proteins containing immunoglobulin-like domains. These are found on external surface cells, such as flagella or conjugative...
Increased life expectancy has promoted research on healthy aging. Aging is accompanied by increased non-specific immune activation (inflammaging) which favors the appearance of several disorders. Here, we study whether dietary supplementation with spray-dried animal plasma (SDP), been shown to reduce gut-associated lymphoid tissue (GALT) in rodents challenged S. aureus enterotoxin B (SEB), and can also prevent effects aging system homeostasis. We first characterized GALT a mouse model...
Alzheimer’s disease (AD) is characterized by the aberrant processing of amyloid precursor protein (APP) and accumulation hyperphosphorylated tau, both which are accompanied neuroinflammation. Dietary supplementation with spray-dried porcine plasma (SDP) has anti-inflammatory effects in inflammation models. We investigated whether dietary SDP prevents neuropathological features AD. The experiments were performed 2- 6-month-old SAMP8 mice fed a control diet, or diet supplemented 8% SDP, for 4...
Arbequina table olive (AO) consumption lowers blood pressure (BP) in spontaneously hypertensive rats (SHR). This study evaluates whether dietary supplementation with AO induced changes the gut microbiota that are consistent purported antihypertensive effects. Wistar-Kyoto (WKY-c) and SHR-c received water, while SHR-o were supplemented by gavage (3.85 g kg-1) for 7 weeks. Faecal was analysed 16S rRNA gene sequencing. showed increased Firmicutes decreased Bacteroidetes compared to WKY-c. BP...
The tongue of the Swiss muse is rich in mast cells (MC). Tongues animals experimental group were irradiated using u He-Ne laser (2.4 J/cm2, 632 nm), and a second set unirradiated served as control. Two output powers used, with irradiation time adjusted to produce same energy dencity. possible nonselective degranulation LLLT-irradiated was examined quantitatively morphometically optic electron microscopy. By means radioimmunoassay, histamisie content pulverized evaluated, comparing levels...
Dietary immunoglobulin concentrates prepared from animal plasma can modulate the immune response of gut-associated lymphoid tissue (GALT). Previous studies have revealed that supplementation with serum-derived bovine immunoglobulin/protein isolate (SBI) ameliorates colonic barrier alterations in mdr1a-/- genetic mouse model IBD. Here, we examine effects SBI on mucosal inflammation mice spontaneously develop colitis. Wild type (WT) and lacking mdr1a gene (KO) were fed diets supplemented...
Dietary supplementation with spray-dried porcine plasma (SDP) can modulate the immune response of gut-associated lymphoid tissue. SDP reduces acute mucosal inflammation, as well chronic inflammation associated aging. The aim this study was to analyze if could ameliorate colitis in a genetic mouse model inflammatory bowel disease (IBD). Wild-type mice and Mdr1a knockout (KO) were administered control diet or an SDP-supplemented from day 21 (weaning) until 56. histopathological index,...
Senescence is characterized by an aggravated inflammatory state that reduces vaccine responsiveness. Dietary supplementation with spray-dried porcine plasma (SDP) exerts anti-inflammatory effects in different mucosal areas. We aimed to determine if the properties of SDP improve efficiency immunization senescent animals.
Antimicrobial resistance (AMR) poses a significant threat to human health. Although vaccines have been developed combat AMR, it has proven challenging associate specific vaccine antigens with AMR. Bacterial plasmids play crucial role in the transmission of Our recent research identified group bacterial (specifically, IncHI plasmids) that encode large molecular mass proteins containing immunoglobulin-like domains. These are found on external surface cells, such as flagella or conjugative...
In vivo studies show that raised aldosterone (Aldo) during low-Na adaptation regulates the growth of pericryptal myofibroblasts and reduces permeability colonic epithelium. The aim this study was to reproduce in vitro condition increased Aldo using human CCD-18Co T84 epithelial cells measure myofibroblast proliferation expression intercellular junction proteins. Proliferation quantified by measuring 5-bromo-2'-deoxyuridine incorporation. EGF, VEGFa, transforming factor-β1 (TGF-β1) measured...
Enteroaggregative Escherichia coli (EAEC) strains are one of the diarrheagenic pathotypes. EAEC harbor a virulence plasmid (pAA2) that encodes, among other determinants, aggR gene. The expression AggR protein leads to several determinants in both plasmids and chromosomes. In this work, we describe novel mechanism influences expression. Because absence Rho-independent terminator 3'UTR, transcripts extend far beyond ORF. These prone PNPase-mediated degradation. Structural alterations 3'UTR...