A5029756504- Yersinia bacterium, plague, ectoparasites research
- Vibrio bacteria research studies
- Antibiotic Resistance in Bacteria
- Bacterial Genetics and Biotechnology
- Pharmacological Effects of Natural Compounds
- Plant-based Medicinal Research
- Bacillus and Francisella bacterial research
- Vector-borne infectious diseases
- Escherichia coli research studies
- Clostridium difficile and Clostridium perfringens research
- Bacterial biofilms and quorum sensing
- Lipid Membrane Structure and Behavior
University of Münster
2017-2021
Harvard University
2019-2020
Significance This paper demonstrates that aminoglycoside antibiotics induce the production of Ap4A in bacteria. Increased intracellular Ap4A, turn, promotes bacterial cell killing by this class antibiotics, which correlated well with elevated damage to membrane upon treatment. These findings reveal a striking connection between and particularly under conditions oxidative stress. Importantly, results study suggest targeting degradation or inducing its hypersynthesis during therapy...
The type 6 secretion system (T6SS) is a dynamic organelle encoded by many gram-negative bacteria that can be used to kill competing bacterial prey species in densely occupied niches. Some predatory species, such as
Effector proteins secreted by the type 3 secretion system (T3SS) of pathogenic bacteria have been shown to precisely modulate important signaling cascades host for benefit pathogens. Among others, non-LEE encoded T3SS effector protein NleC enteropathogenic Escherichia coli (EPEC) is a Zn-dependent metalloproteinase and suppresses innate immune responses directly targeting NF-κB pathway. Many release potent bacterial toxins A-B type, which - in contrast direct cytoplasmic injection are...
Virulence gene expression of Yersinia pseudotuberculosis changes during the different stages infection and this is tightly controlled by environmental cues. In study, we show that small protein YmoA, a member Hha family, part process. It controls temperature- nutrient-dependent early later stage virulence genes in an opposing manner co-regulates bacterial stress responses metabolic functions. Our analysis further revealed YmoA exerts function modulating global post-transcriptional regulatory...
Type VI secretion systems (T6SSs) are complex macromolecular injection machines which widespread in Gram-negative bacteria. They involved host-cell interactions and pathogenesis, required to eliminate competing bacteria, or important for the adaptation environmental stress conditions. Here we identified regulatory elements controlling T6SS4 of Yersinia pseudotuberculosis found a novel type hexameric transcription factor, RovC. RovC directly interacts with promoter region activates alone...
Abstract Enteropathogenic Yersiniae evolved a plethora of virulence traits which allow them to colonize the intestine and gut-associated lymphatic tissues mammals. In these host niches they have tightly adjust expression required pathogenicity factors resist attacks by immune system. Here, we present how enteric use intricate control networks include numerous regulatory sensory RNAs, RNA-binding proteins RNases their attributes.