A5047639387- Thyroid Disorders and Treatments
- Pituitary Gland Disorders and Treatments
- Adrenal and Paraganglionic Tumors
- Adrenal Hormones and Disorders
- Hormonal Regulation and Hypertension
- Thyroid Cancer Diagnosis and Treatment
- Neonatal Health and Biochemistry
- Growth Hormone and Insulin-like Growth Factors
- Cancer, Lipids, and Metabolism
- Sodium Intake and Health
- Lipid metabolism and disorders
- Radiation Dose and Imaging
- Maternal and fetal healthcare
- Peroxisome Proliferator-Activated Receptors
- Chemical Analysis and Environmental Impact
- Selenium in Biological Systems
- Pregnancy and preeclampsia studies
- Potassium and Related Disorders
- Hormonal and reproductive studies
- Neuroendocrine Tumor Research Advances
- Cancer, Hypoxia, and Metabolism
- TGF-β signaling in diseases
- Cardiac, Anesthesia and Surgical Outcomes
- Mercury impact and mitigation studies
- Congenital Diaphragmatic Hernia Studies
Royal Victoria Hospital
2012-2024
University of Ulster
2012-2024
Belfast Health and Social Care Trust
2019-2024
Victoria Hospital
2013-2022
Diabetes Australia
2009-2015
Diabetes UK
2012
Queen's University Belfast
2011
657 Oslo
2007
Trinity College Dublin
2004-2005
Tallaght University Hospital
2004
Abstract Context: Subclinical Cushing’s syndrome has been described among diabetic populations in recent years, but no consensus emerged about the value of screening. Methods: We enrolled 201 consecutive patients attending our diabetes clinic and 79 controls. Patients with at least two following three criteria were offered screening using a 2300 h salivary cortisol test: glycosylated hemoglobin 7%, body mass index 25 kg/m2, history hypertension or blood pressure 140/90 mm Hg. Results are...
Early childhood inorganic arsenic (i-As) exposure is of particular concern since it may adversely impact on lifetime health outcomes. Infants' urinary (As) metabolites were analysed in 79 infants by inductively coupled plasma-mass spectrometric detection (IC-ICP-MS) to evaluate i-As pre- and post-weaning. Levels rice-based weaning infants' foods also determined relate As levels. Higher levels, especially monomethylarsonic acid (MMA) dimethylarsinic (DMA), found urine from formula fed...
Peroxisomal proliferator-activated receptors (PPAR)- gamma are expressed abundantly in ACTH-secreting pituitary tumours. The PPAR-gamma activator rosiglitazone has been shown to suppress ACTH secretion human adrenocorticotroph tumour cells vitro, and prevent reduce development mouse models vivo.To evaluate the effect of patients with persistently elevated plasma levels postbilateral adrenalectomy for Cushing's disease.Seven were treated 8 mg orally per day 12 weeks.Plasma was measured at two...
Cyclical Cushing's syndrome is a pattern of hypercortisolism in which the biochemistry cortisol production fluctuates rhythmically. This often associated with fluctuating symptoms and signs. It now being increasingly recognized. The phenomenon important because it can, if not recognized, lead to errors diagnosis differential assessment therapeutic outcomes. techniques criteria, protocols dynamic biochemical tools detect cycling patients are discussed as strategies for diagnosing managing...
Abstract Context Head and neck paragangliomas (HNPGLs) are rare, usually benign, slow‐growing tumours arising from neural crest‐derived tissue. Definitive management pathways for HNPGLs have yet to be clearly defined. Objective To review our experience of the clinical features these analyse outcomes different treatment modalities. Methods Demographic data were obtained The Northern Ireland Electronic Care Record (NIECR) as well a prospectively maintained HNPGL database between January 2011...
Cyclical Cushing's syndrome is detected in our center by collecting sequential early morning urine (EMU) samples for cortisol to creatinine ratio over 28 d. The Endocrine Society suggests that nocturnal salivary (NSC) may be used assess patients cyclical Cushing's. However, there only very limited evidence it correlates with EMU testing or demonstrates cycling d.We sought correlate NSC results collected the following and determine whether could detect Cushing's.An observation study of 28-d...
Abstract Objective Mild iodine deficiency has re‐emerged among school girls in the UK. We wished to study a contemporaneous pregnant population because relationship between maternal and offspring cognitive scores recently been reported. The WHO set median urinary concentration (UIC) of ≥100 ≥150 µg/L define adequacy outside during pregnancy, respectively. Iodine creatinine ratio (ICR) is also used correct for dilution effects (sufficiency µg/g pregnancy). Design methods A total 241 women...
Background: Microsomal triglyceride transfer protein (MTP) regulates the assembly of chylomicrons in intestine and very-low-density lipoprotein (VLDL) liver. Common polymorphisms have been described that do not affect lipoproteins non-diabetic subjects. Their effect diabetes has a Caucasian population. Aim: To investigate association these three common with type 2 diabetes. Methods: Eighty-two patients consumed high-fat test meal. Chylomicron VLDL apoB48, apoB100, cholesterol, triglycerides...
Iodine is an essential micronutrient important for foetal nerve and brain development, especially in the early stages of pregnancy. The re-emergence mild to moderate iodine deficiency has recently been reported United Kingdom (UK). level knowledge amongst pregnant women regarding nutrition poorly understood. aim this study was determine about during pregnancy among living Northern Ireland (NI). A cross-sectional carried out Royal Jubilee Maternity Hospital Belfast, from March June 2015. Two...
Patients with primary aldosteronism (PA) who are suitable for surgery should undergo adrenal computerised tomography (CT) and venous sampling (AVS). A retrospective study was performed of 100 patients PA. We determined the optimal AVS lateralisation ratio unilateral disease reviewed adrenalectomy outcomes evaluating which characteristics predicted hypertension cure.AVS in 93 patients. Lateralisation criteria were assessed using ROC curve analysis. The outcome 39 predictive factors cure...
Abstract Background Iodine deficiency has re-emerged among pregnant cohorts in the UK. Thyroglobulin (Tg) is a protein produced uniquely by thyroid gland which appears to mount U-shaped response extremes of iodine status. Tg been suggested as an alternative marker for chronic but value pregnancy not fully elucidated. A recent non-European study median ≤10 µg/L with <3% values >44 was indicative sufficiency second trimester pregnancy. Methods We measured serum levels each 241 women...
Cushing’s disease is a rare condition that occurs due to an adrenocorticotrophin-producing corticotrophinoma arising from the pituitary gland. The consequent hypercortisolaemia results in multisystem morbidity and mortality. This study aims report incidence, clinicopathological characteristics, remission outcomes mortality regional neurosurgical cohort of patients diagnosed with Northern Ireland (NI) 2000 2019. Clinical, biochemical radiological data operated for were retrospectively...
It is established that external pituitary irradiation (EPI) effectively reduces serum GH levels in acromegaly. However, its effect normalising IGF1 has been disputed. We looked at the number of our patients who achieved persistently normal whilst free adjunctive treatment for least 1 year after EPI.We identified 63 acromegalic between 1964 and 2004 received EPI. Six were excluded: three had surgery EPI, two no medical records available, one a Yttrium implant.Patients 4500-5000 cGy...