A5102822556- Occupational and environmental lung diseases
- Mesenchymal stem cell research
- Liver physiology and pathology
- Viral Infectious Diseases and Gene Expression in Insects
- Toxic Organic Pollutants Impact
- Cancer, Hypoxia, and Metabolism
- Aquatic Ecosystems and Phytoplankton Dynamics
- CAR-T cell therapy research
- Cytomegalovirus and herpesvirus research
- Tissue Engineering and Regenerative Medicine
- ATP Synthase and ATPases Research
- Pancreatic and Hepatic Oncology Research
- Autophagy in Disease and Therapy
- Cancer Cells and Metastasis
- Mercury impact and mitigation studies
- Hepatitis B Virus Studies
- Virus-based gene therapy research
- Hepatitis C virus research
- Chemical Analysis and Environmental Impact
- Cancer Research and Treatments
- Curcumin's Biomedical Applications
- Endoplasmic Reticulum Stress and Disease
Hebei Medical University
2019-2022
Second Hospital of Hebei Medical University
2019-2022
First People’s Hospital of Jingmen
2020
Tsinghua University
2019
Qilu Hospital of Shandong University
2018
Seventh People's Hospital of Dalian
2009
Northeast Normal University
2006
BACKGROUND Baicalin, one of the main bioactive components extracted from traditional Chinese medicine baical Skullcap root, has an anti-tumor activity which had been studied in several cancers. However, its role human mesothelioma remains unknown. In this study, we investigated mechanisms baicalin cell line MESO924. MATERIAL AND METHODS Effects on were assessed by measuring viability, apoptosis, migration, invasion, inactivation signaling intermediates, and cell-cycle alterations. RESULTS...
Viral-based chimeric antigen receptor-engineered T (CAR T)-cell manufacturing has potential safety risks and relatively high costs. The nonviral minicircle DNA (mcDNA) is safer for patients, cheaper to produce, may be a more suitable technique generate CAR cells. In this study, we produced mcDNA-based cells specifically targeting prostate stem cell (PSCA; mcDNA-PSCA-CAR cells). Our results showed that persisted in mouse peripheral blood as long 28 days demonstrated T-cell infiltration,...
The early detection of pancreatic ductal adenocarcinoma (PDAC) dramatically improves outcome. All available state-of-the-art imaging methods allow with EUS being the best technique for exclusion PDAC and very PDAC. Etiological differentiation small SPL is important to guide individually tailored patients management including radical surgery in resectable PDAC, medical (neoadjuvant or palliative intended) treatment non-resectable malignancy, parenchyma saving strategies some non-PDAC,...
Curcumin is a conventional Chinese medicine, which exerts marked effect on various tumor types and suppresses invasion. The present study analyzed the antineoplastic effects of curcumin human nasopharyngeal carcinoma (NPC) cells determined endoplasmic reticulum (ER) stress curcumin‑induced cytotoxicity. Cell Counting Kit‑8 assay examined viability SUNE1 SUNE2 NPC cells. Annexin V/propidium iodide staining technique was used to detect cell apoptosis flow cytometry examine cycle distribution....
There are many researches on using bone marrow mesenchymal stem cells (BMSCs) in the treatment of acute kidney injury (AKI), which has certain effects, but mechanism action is still unclear. Previous show that glioma-associated oncogene homolog 1 (Gli 1) can promote proliferation and migration cells, also renal fibrosis. Therefore, we investigate influence Gli-regulated BMSCs repairing AKI fibrosis induced by limb Ischemia-Reperfusion (I/R).The Crispr-Cas9 technique was adopted to knock out...