A5064485021- CAR-T cell therapy research
- Immune Cell Function and Interaction
- Cancer Immunotherapy and Biomarkers
- Immunotherapy and Immune Responses
- Mycobacterium research and diagnosis
- Reproductive System and Pregnancy
- Cancer-related molecular mechanisms research
- Atherosclerosis and Cardiovascular Diseases
- Acute Lymphoblastic Leukemia research
- Virus-based gene therapy research
- Melanoma and MAPK Pathways
- Veterinary Pharmacology and Anesthesia
- Acute Myeloid Leukemia Research
- Hepatocellular Carcinoma Treatment and Prognosis
- Ferroptosis and cancer prognosis
- Microbial infections and disease research
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Anesthesia and Pain Management
- Lymphoma Diagnosis and Treatment
- Anesthesia and Sedative Agents
- Viral Infectious Diseases and Gene Expression in Insects
- Cutaneous Melanoma Detection and Management
- MicroRNA in disease regulation
- Cytokine Signaling Pathways and Interactions
- Cancer Cells and Metastasis
Hebei University of Engineering
2012-2025
Affiliated Hospital of Hebei University
2012-2022
Hebei Medical University
2019
Hepatocellular carcinoma (HCC) is the fifth most common tumor worldwide and has a very poor prognosis. Its occurrence been on increase in recent years. Surgical resection liver transplantation are primary methods of treatment for HCC patients, but can only be applied to 15% patients. The median survival time unresectable or metastasizing patients few months. Existing systemic not effective advanced new method needed these It established that occurs multiple stages, however, pathogenesis at...
Programmed cell death protein 1 (PD-1) is an immune checkpoint receptor that functions to attenuate T activation. In this study, we knocked out (KO) PD-1 in cytotoxic lymphocytes (CTLs) using CRISPR-Cas9 system evaluate its effect on the anti-tumor activity of CTLs against multiple myeloma (MM). Results show KO facilitate apoptosis and caspase activation co-cultured MM cells enhanced by 36% compared with control. also increased TNF-α IFN-γ secretion 2.4 1.9-fold respectively. The...
The purpose of this study was to investigate the pathogenesis colorectal cancer (CRC) and effects long noncoding RNA plasmacytoma variant translocation 1 (PVT1) on CRC progression. Bioinformatics analysis verified PVT1 expression in tumor normal tissues. Quantitative PCR western blotting were used measure mRNA protein levels, respectively. MTT, Transwell, colony formation, vivo assays assess proliferation, migration, invasion by cells. Both microRNA (miR)-152-3p shown be colocalized cells...
Atherosclerosis correlates with ischemic cardio-cerebrovascular diseases such as coronary heart disease. Long non-coding RNAs (lncRNAs) can promote atherosclerosis. We investigated the role of lncRNA AK136714 in Compared healthy group, expression was elevated plaque and plasma atherosclerosis patients a GEO dataset. silencing inhibited formation ApoE-/- mice. also protected endothelial barrier cell inflammation.
Viral-based chimeric antigen receptor-engineered T (CAR T)-cell manufacturing has potential safety risks and relatively high costs. The nonviral minicircle DNA (mcDNA) is safer for patients, cheaper to produce, may be a more suitable technique generate CAR cells. In this study, we produced mcDNA-based cells specifically targeting prostate stem cell (PSCA; mcDNA-PSCA-CAR cells). Our results showed that persisted in mouse peripheral blood as long 28 days demonstrated T-cell infiltration,...
Aim: To produce dendritic cells (DCs) from CD34+ stem cord blood and explore their prophylactic curative effect against tumors by vaccinating humanized NSG mice. Materials & methods: Separated were cultured for 30 days, the resultant DCs (CD34-DCs) collected. The basic function of CD34-DCs cytotoxicity CD34-cytotoxic-T lymphocytes (CTLs) tested in vitro, tumor inhibition a mouse model was observed. Results: number reached approximately 9 log. These performed functions similar to those...
The study focused on how to improve the diagnostic coincidence rate of patients with gallbladder stones and cancer based an optimized Segnet network algorithm relationship multiple tumor suppressor 1 (P16). 300 diagnosed in hospital were selected as research subjects. pyramid pooling operation was incorporated into original algorithm, its performance evaluated, factoring intersection union (IoU), precision (Pre), recall (Recall). After 8 hours fasting, conventional ultrasound...
Extracted MenSC (Menstrual blood-derived stem cells) from female menstrual blood. Added various exogenous factors in-vitro and simulated the uterine environment to observe how make differentiation into Endometrial epithelial cells by artificial induction. MenSCs were divided 4 groups: 2.5×10 −5 mol/L E group, 1.613 nmol/L EGF E+1.613 control Group (only MenSCs); relevant indicators of experiment includes cell staining Western Blot detect CK VIM protein content; RT-PCR CK-19 mRNA mRNA. The...