A5100633531- Genetic Associations and Epidemiology
- Functional Brain Connectivity Studies
- RNA and protein synthesis mechanisms
- Nerve injury and regeneration
- Peptidase Inhibition and Analysis
- Cancer, Hypoxia, and Metabolism
- Advanced Neuroimaging Techniques and Applications
- RNA modifications and cancer
- Renal cell carcinoma treatment
- Ion Transport and Channel Regulation
- Chemical synthesis and alkaloids
- Hypothalamic control of reproductive hormones
- Genetic Mapping and Diversity in Plants and Animals
- Healthcare and Venom Research
- CRISPR and Genetic Engineering
- RNA Research and Splicing
- Transcranial Magnetic Stimulation Studies
- Ferroptosis and cancer prognosis
- Neurological Disorders and Treatments
- Tryptophan and brain disorders
- Obsessive-Compulsive Spectrum Disorders
- Receptor Mechanisms and Signaling
- Neurological disorders and treatments
- Autism Spectrum Disorder Research
- Wnt/β-catenin signaling in development and cancer
Chongqing Medical University
2025
Zhejiang University
2023
Henan Psychiatric Hospital
2011-2020
Xinxiang Medical University
2011-2020
Objectives: Schizophrenia (SZ), major depressive disorder (MDD) and bipolar (BD) are serious mental disorders with distinct diagnostic criteria. They share common clinical biological features. However, there still only few studies on the specific brain imaging changes associated three disorders. Therefore, aim of this study to was identify functional activity connectivity in SZ, MDD, BD. Methods: A total 271 individuals underwent magnetic resonance imaging: SZ (n = 64), MDD 73), BD 41),...
Abstract The clustered regularly interspaced short palindromic repeats (CRISPR)/Cas12a system exhibits extraordinary capability in the field of molecular diagnosis and biosensing, attributed to its trans-cleavage ability. precise modulation performance has emerged as a significant challenge advancing CRISPR technology next stage development. Herein, we reported CRISPR/Cas12a regulation strategy based on an overhanging activator. presence domains activators creates steric hindrances that have...
Schizophrenia (SZ) is a complex polygenic psychiatric disorder caused in part by abnormal dopamine levels. Cerebral neurotrophic factor (CDNF) 2 known to protect and repair the dopaminergic system. Dopamine dysfunction one of pathogenesis SZ. However, relationship between CDNF2 SZ has not been previously investigated. We speculated that may be susceptibility for To address this issue, we carried out study investigate association total sample 1371 (670 patients 701 healthy controls) Han...
Objectives: Abnormal activity of the subgenual anterior cingulate cortex (sACC) is implicated in depression, suggesting sACC as a potentially effective target for therapeutic modulation cases resistant to conventional treatments (treatment-resistant TRD). We hypothesized that areas prefrontal (PFC) with direct fiber connections may be particularly sites treatment using transcranial magnetic stimulation (TMS). The aim this study was identify PFC most strongly connected sACC. Methods: Two...
Schizophrenia (SZ) is a complex psychiatric disorder that has strong genetic basis. Dystrobrevin-binding protein 1 (DTNBP1) one of the genes thought to be pivotal in regulating glutamatergic system. Studies have suggested variations DTNBP1 confer susceptibility SZ and clinical symptoms. Here, we performed two-stage independent verification study identify polymorphisms gene might associated with Han Chinese population. In stage 1, 14 single nucleotide (SNPs) were genotyped 528 paranoid...
During ribosome biogenesis, the small subunit (SSU) processome is responsible for 40S assembly. The BMS1/RCL1 complex a core component of SSU that plays an important role in 18S rRNA processing and maturation. Genetic studies using zebrafish mutants indicate both Bms1-like (Bms1l) Rcl1 are essential digestive organ development. In spite vital functions this complex, mutual dependence these two nucleolar proteins stability function remains elusive. study, we identified RCL1-interacting domain...
Schizophrenia (SZ) is a common and complex psychiatric disorder that has significant genetic component. The glutamate hypothesis describes one possible pathogenesis of SZ. solute carrier family 1 gene (SLC1A1) several genes thought to play critical role in regulating the glutamatergic system strongly implicated pathophysiology In this study, we identify polymorphisms SLC1A1 may confer susceptibility SZ Han Chinese population.We genotyped 36 single-nucleotide (SNPs) using Illumina GoldenGate...
Objective: Although Sickle Cell Disease (SCD) is prevalent in Saudi-Arabia, there have been no data about the prevalence of low bone mineral density (BMD) adult patients suffering from SCD eastern region KSA.Our study aimed to assess with KSA and its association other sickle cell disease manifestations.Methodology: In King Faisal University Polyclinic, Al-Ahsa, Saudi Arabia, a cross sectional was carried out.Ninety known suffer between August 2017 May 2018 were recruited for study.Patients...
Objective To investigate the potential association of Ghrelin(GHRL)gene polymorphisms susceptible to schizophrenia by case-control study.Methods Six hundred and thirty-four patients,six six healthy control subjects were recruited.Four SNPs rs696217,rs26802,rs27647 rs26311 detected polymerase chain reaction-based-restriction fragment length polymorphism analysis.Results No significant differences in genotype or allele frequencies four observed between schizophrenic patients controls (Pvalues...