A5087599157- Cardiovascular, Neuropeptides, and Oxidative Stress Research
- Ion Channels and Receptors
- Galectins and Cancer Biology
- Pulmonary Hypertension Research and Treatments
- Wnt/β-catenin signaling in development and cancer
- Neurobiology and Insect Physiology Research
- Magnesium in Health and Disease
- Nitric Oxide and Endothelin Effects
Fujian Medical University
2018-2021
Johns Hopkins Medicine
2018
Johns Hopkins University
2018
Pulmonary hypertension (PH) is characterized by profound vascular remodeling and altered Ca2+ homeostasis in pulmonary arterial smooth muscle cells (PASMCs). Magnesium ion (Mg2+), a natural antagonist cofactor for numerous enzymes, crucial regulating diverse cellular functions, but its roles PH remains unclear. Here, we examined the of Mg2+ transporters development. Chronic hypoxia monocrotaline induced significant adult male rats. It was associated with reduction [Mg2+]i PASMCs, increase...
5-Hydroxytryptamine (5-HT)-dependent signaling mediated through its transporters and receptors plays important roles in chronic hypoxic pulmonary hypertension (CHPH), which is associated with aberrant reactive oxygen species (ROS) production. NADPH oxidase 4 (NOX4) one of the major sources ROS vasculature, has been implicated development PH. NOX4 generates H2O2, can activate transient receptor potential melastatin 2 (TRPM2) channels, providing Ca2+ signals for cell proliferation migration....
Pulmonary hypertension (PH) is characterized by enhanced vasoconstriction and vascular remodeling, which are attributable to the alteration of Ca<sup>2+</sup> homeostasis in pulmonary arterial smooth muscle cells (PASMCs). It well established that store-operated entry (SOCE) augmented PASMCs during PH it plays a crucial role development. Our previous studies showed melastatin-related transient receptor potential 8 (TRPM8) down-regulated animal models, activation TRPM8 causes relaxation...