A5087799605- Hedgehog Signaling Pathway Studies
- Immune Response and Inflammation
- Heat shock proteins research
- Developmental Biology and Gene Regulation
- Magnesium in Health and Disease
- NF-κB Signaling Pathways
- Genetics, Aging, and Longevity in Model Organisms
- Endoplasmic Reticulum Stress and Disease
- Chemokine receptors and signaling
- RNA Research and Splicing
- TGF-β signaling in diseases
- Pulmonary Hypertension Research and Treatments
- Epigenetics and DNA Methylation
- Axon Guidance and Neuronal Signaling
- Genetic Neurodegenerative Diseases
- Cancer-related gene regulation
- Ubiquitin and proteasome pathways
- Spaceflight effects on biology
- Sphingolipid Metabolism and Signaling
- Bone health and treatments
- Wnt/β-catenin signaling in development and cancer
- Proteoglycans and glycosaminoglycans research
- Cytokine Signaling Pathways and Interactions
- Transplantation: Methods and Outcomes
- Inflammatory mediators and NSAID effects
Center for Cancer Research
2022-2023
Cancer Genetics (United States)
2022-2023
National Cancer Institute
2022-2023
Fujian Medical University
2020-2022
Government of the United States of America
2022
George Washington University
2019-2022
Florida State University
2016
National Yang Ming Chiao Tung University
2010-2015
National Taipei University
2010-2015
Pulmonary hypertension (PH) is characterized by profound vascular remodeling and altered Ca2+ homeostasis in pulmonary arterial smooth muscle cells (PASMCs). Magnesium ion (Mg2+), a natural antagonist cofactor for numerous enzymes, crucial regulating diverse cellular functions, but its roles PH remains unclear. Here, we examined the of Mg2+ transporters development. Chronic hypoxia monocrotaline induced significant adult male rats. It was associated with reduction [Mg2+]i PASMCs, increase...
Breast cancer is a common leading to many deaths among females. Cyclooxygenase-2 (COX-2) and interleukin-8 (IL-8) are two highly expressed inflammatory mediators be induced by the protein kinase C (PKC) signaling via various stimuli both contribute significantly metastasis/progression. Glucosamine has been shown act as an anti-inflammation molecule. The aim of this study was clarify role acting mechanism glucosamine during PKC-regulation COX-2/IL-8 expression associated impact on breast...
Ubiquilin proteins contain a ubiquitin-like domain (UBL) and ubiquitin-associated domain(s) that interact with the proteasome ubiquitinated substrates, respectively. Previous work established link between ubiquilin mutations neurodegenerative diseases, but function of remains elusive. Here we used misfolded huntingtin exon I containing 103-polyglutamine expansion (Htt103QP) as model substrate for functional study proteins. We found yeast mutant (dsk2Δ) is sensitive to Htt103QP overexpression...
Despite its pivotal roles in biology, how the transcriptional activity of c-MYC is tuned quantitatively remains poorly defined. Here, we show that heat shock factor 1 (HSF1), master regulator response, acts as a prime modifier c-MYC-mediated transcription. HSF1 deficiency diminishes DNA binding and dampens genome wide. Mechanistically, c-MYC, MAX, assemble into transcription complex on genomic DNAs, surprisingly, dispensable. Instead, physically recruits histone acetyltransferase general...
Acute inflammation is often observed during acute lung injury (ALI) and respiratory distress syndrome. Glucosamine known to act as an anti-inflammatory molecule. The effects of glucosamine on its associated mechanisms remain unclear. present study sought address how plays role in vivo vitro. Using the LPS intratracheal instillation-elicited rat model, we found that attenuated pulmonary edema polymorphonuclear leukocyte infiltration, well production TNF-α, IL-1β, cytokine-induced neutrophil...
Clinical and preclinical studies show tissue-specific differences in tumorigenesis. Tissue specificity is controlled by differential gene expression. We prioritized genes that encode secreted proteins according to their preferential expression normal lungs identify candidates associated with lung cancer. Indeed, most of the lung-enriched identified our analysis have known or suspected roles focused on encoding neuron-derived neurotrophic factor (NDNF), which had not yet been determined NDNF...
Hedgehog (Hh) and Bone Morphogenetic Proteins (BMPs) pattern the developing Drosophila wing by functioning as short- long-range morphogens, respectively. Here, we show that a previously unknown Hh-dependent mechanism fine-tunes activity of BMPs. Through genome-wide expression profiling imaginal discs, identify nord novel target gene Hh signaling pathway. Nord is related to vertebrate Neuron-Derived Neurotrophic Factor (NDNF) involved in congenital hypogonadotropic hypogonadism several types...
LPS can activate the inflammatory cascades by inducing various mediators, such as prostaglandin E 2 (PGE ) resulting from cyclooxygenase-2 (COX-2), and NO produced inducible synthase (iNOS). Lysophosphatidic acid (LPA) has been demonstrated to participate in inflammation. This study aimed clarify impact involving mechanisms of LPA on LPS-incurred inflammation macrophages. First, appeared attenuate LPS-induced protein mRNA expression COX-2 iNOS genes, well production PGE NO. By using...
Hedgehog (Hh) signaling is crucial for establishing complex cellular patterns in embryonic tissues and maintaining homeostasis adult organs. In Drosophila, Interference hedgehog (Ihog) or its close paralogue Brother of Ihog (Boi) forms a receptor with Patched to mediate intracellular Hh signaling. proteins (Ihog Boi) also contribute cell segregation wing imaginal discs through an unknown mechanism independent their role transducing the signal. Here, we report molecular by which cell–cell...
Vascular calcification has been considered as a potential therapeutic target in pulmonary hypertension. Mg2+ protective role against calcification. This study aimed to investigate whether could alleviate hypertension by reducing medial of arteries.Monocrotaline (MCT)-induced and chronic hypoxia-induced rats were given an oral administration 10% MgSO4 (10 ml/kg per day). Additionally, we administered calcified artery smooth muscle cells (PASMCs) after incubating with β-glycerophosphate (β-GP,...
Despite its pivotal roles in biology, how the transcriptional activity of c-MYC is tuned quantitatively remain poorly defined. Here, we show that heat shock factor 1 (HSF1), master regulator heat-shock response, acts as a prime modifier c-MYC-mediated transcription. HSF1 deficiency diminishes DNA binding and dampens genome-widely. Mechanistically, c-MYC, MAX, assemble into transcription complex on genomic DNAs and, surprisingly, dispensable. Instead, physically recruits histone...
Lung transplantation is one therapeutic treatment for severe lung dysfunctions. transplant recipients often face a higher mortality rate of approximately 50% the patients within five years and more frequent loss graft function, as compared to other organ transplants. ischemia reperfusion (I/R) injury most common cause respiratory failure during first 72 hr after transplantation. In fact, I/R risk factor producing diverse pro-inflammatory cytokines leading pulmonary inflammation bronchiolitis...
ABSTRACT Despite its pivotal roles in biology, how the transcriptional activity of c-MYC is attuned quantitatively remain poorly defined. Here, we show that heat shock factor 1 (HSF1), master regulator heat-shock, or proteotoxic stress, response, acts as a key modifier c-MYC-mediated transcription. HSF1 deficiency diminishes DNA binding and dampens genome-widely. Mechanistically, c-MYC, MAX, assemble into transcription complex on genomic DNAs and, surprisingly, dispensable. Instead,...
ABSTRACT Hedgehog (Hh) and bone morphogenetic proteins (BMPs) pattern the developing Drosophila wing by functioning as short- long-range morphogens, respectively. Here, we show that a previously unknown Hh-dependent mechanism fine-tunes activity of BMPs. Through genome-wide expression profiling imaginal discs, identify nord novel target gene Hh signaling pathway. Nord is related to vertebrate Neuron Derived Neurotrophic Factor (NDNF) involved in Congenital Hypogonadotropic Hypogonadism...