A5101848987- Sexual function and dysfunction studies
- Urological Disorders and Treatments
- Epigenetics and DNA Methylation
- Cancer-related molecular mechanisms research
- COVID-19 Clinical Research Studies
- Hormonal and reproductive studies
- Kidney Stones and Urolithiasis Treatments
- COVID-19 and healthcare impacts
- Erythrocyte Function and Pathophysiology
- Cancer Mechanisms and Therapy
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Cancer Genomics and Diagnostics
- COVID-19 Impact on Reproduction
- Urinary Bladder and Prostate Research
- Hemoglobinopathies and Related Disorders
- Sexuality, Behavior, and Technology
- Genital Health and Disease
- Heme Oxygenase-1 and Carbon Monoxide
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- Geochemistry and Elemental Analysis
- Lung Cancer Treatments and Mutations
- CNS Lymphoma Diagnosis and Treatment
- Long-Term Effects of COVID-19
- Streptococcal Infections and Treatments
- Osteoarthritis Treatment and Mechanisms
Sidney Kimmel Comprehensive Cancer Center
2024
Johns Hopkins University
2019-2024
Southwest Hospital
2010-2023
Army Medical University
2010-2023
Southwest University
2023
Johns Hopkins Medicine
2022
Sun Yat-sen University
2015-2020
Sun Yat-sen University Cancer Center
2015-2020
Cixian People's Hospital
2020
Sibley Memorial Hospital
2019
Summary Background To date, large amounts of epidemiological and case study data have been available for the Coronavirus Disease 2019 (COVID-19), which suggested that mortality was related to not just respiratory complications. Here, we specifically analyzed kidney functions in COVID-19 patients their relations mortality. Method In this multi-centered, retrospective, observational study, included 193 adult with laboratory-confirmed from 2 hospitals Wuhan, 1 hospital Huangshi (Hubei province,...
To investigate the clinical and epidemiological characteristics of paediatric patients with coronavirus disease-19 (COVID-19). Paediatric diagnosed COVID-19 between January 15 March 15, 2020, from seven hospitals in Zhejiang Province, China, were collected retrospectively analysed. Thirty-two children COVID-19, ranging age 3 months to 18 years, enrolled. Family aggregation occurred 87.5% infant preschool-aged (7/8), also school-aged (14/16), but only 12.5% (1/8) adolescents (p < 0.05, p...
Diabetes mellitus-induced erectile dysfunction is a common diabetic complication, and new therapeutics the pathogenesis of diabetes need to be investigated.The aim was investigate pharmacological mechanism simvastatin treatment in model rats.A total 86 male Sprague Dawley rats aged 8 weeks old were used this study. The divided into three groups: control (normal), (streptozotocin-injected), + (sim). Each group subdivided two subgroups for vitro vivo analyses. A bioinformatics method detect...
Clinical and preclinical studies show tissue-specific differences in tumorigenesis. Tissue specificity is controlled by differential gene expression. We prioritized genes that encode secreted proteins according to their preferential expression normal lungs identify candidates associated with lung cancer. Indeed, most of the lung-enriched identified our analysis have known or suspected roles focused on encoding neuron-derived neurotrophic factor (NDNF), which had not yet been determined NDNF...
This study compared tankyrase 1 expression and autophagy quantity between erectile dysfunction (ED) non-ED rats' corpus cavernosum smooth muscle cells (CSMCs).This aslo explored the effect possible mechanism of on cell proliferation in ageing ED CSMCs.The intracavernous pressure mean systemic arterial were measured to investigate function so that eight 24-month-old 8-month-old male Wistar rats choosed respectively.The rat CSMCs isolated cultured by enzyme digestion, which compared.Tankyrase...
The aim of the present study was to investigate activities novel synthetic epidermal growth factor receptor (EGFR) inhibitors (ZINC05463076, ZINC2102846 and ZINC19901103) against prostate tumors, in vitro models potential underlying mechanisms. A panel tumor cell lines (LNCaP, DU-145, PC-3 LNCaP-AI cells) were used evaluate antitumor activity ZINC05463076, ZINC2102846, ZINC19901103 vitro. Cell clonal formation determined by MTT assay Soft agar colony assay, respectively. An EGFR kinase...
// Mian Xie 1 , Xiaojun Wu 2 Chaosheng He 3 Jiexia Zhang Jinjun 4 China State Key Laboratory of Respiratory Disease and Guangzhou Institute Disease, The First Affiliated Hospital Medical University, Guangzhou, Oncology in Southern China, Department Colorectal Surgery, Sun Yat-Sen University Cancer Center, Internal Medicine, Guangdong General Hospital, Anesthesiology, Correspondence to: Xie, e-mail: mianxie@gird.cn Keywords: lung cancer, Ski, DNA methylation, prognosis Received: July 20,...
Refractory anemia with ring sideroblasts associated marked thrombocytosis (RARS-T) is an uncommon and provisional entity per the World Health Organization classification.This includes myelodysplastic features: anemia, dysplastic features, sideroblasts, prominent megakaryocytic hyperplasia thrombocytosis.The majority of RARS-T cases have shown JAK2V617F mutation.For patients in crisis severe thrombocytosis, important therapeutic option thrombocytapheresis (TC), which can be lifesaving setting...
Objective To study the component ratios of pancreatic carcinoma, and prognosis patients with different pathological types. Methods The data 92 011 carcinoma who were diagnosed by definite method from 2004 to 2014 extracted US SEER database. The life table was used calculate 1-, 3- 5-year survival rates. Kaplan-Meier construct curves patients. Cox univariate analysis applied evaluate HR types, χ2 test independent sample t-test baseline data. Results The overall 7.6%. median time...
Objective To study the impact factors on prognosis of patients with gallbladder adenocarcinoma after surgery. Methods The clinicopathological data 1 285 who underwent surgery and were histologically confirmed to have from 2004 2014 was extracted SEER database US National Cancer Institute. Life table used calculate survival rate. Kaplan-Meier construct curves. Univariate Cox multivariate regression analysis applied evaluate prognostic factors. The univariate evaluated by log-rank χ2...
Abstract Background Lymphovascular invasion (LVI) and perineural (PNI) can indicate poor survival outcomes in colorectal cancer, but few studies have focused on stage III colon cancer. The current study aimed to confirm the prognostic value of LVI PNI identify patients who could achieve benefit from a complete duration adjuvant chemotherapy based two pathological factors. Methods We enrolled 402 consecutive with cancer receive tumor resection November 2007 June 2016 at Sun Yat-sen University...