A5114334461- vaccines and immunoinformatics approaches
- MicroRNA in disease regulation
- Plant biochemistry and biosynthesis
- Extracellular vesicles in disease
- Pluripotent Stem Cells Research
- Single-cell and spatial transcriptomics
- Biochemical and Structural Characterization
- Transgenic Plants and Applications
- RNA Interference and Gene Delivery
- CRISPR and Genetic Engineering
- Virology and Viral Diseases
- Ginseng Biological Effects and Applications
- Chemical Synthesis and Analysis
- Genomics and Chromatin Dynamics
- Adipose Tissue and Metabolism
- Reproductive System and Pregnancy
- Osteoarthritis Treatment and Mechanisms
- Plant tissue culture and regeneration
- Immunotherapy and Immune Responses
- Photosynthetic Processes and Mechanisms
- HIV Research and Treatment
- Ovarian function and disorders
- Gene expression and cancer classification
- Immune cells in cancer
- Phytochemical and Pharmacological Studies
Yale University
2023-2025
Northwest Minzu University
2024
Henan Academy of Agricultural Sciences
2022-2024
Jilin Agricultural University
2024
Southern Medical University
2023
Key Laboratory of Guangdong Province
2023
South China Agricultural University
2023
Sun Yat-sen Memorial Hospital
2016-2022
Sun Yat-sen University
2016-2022
Chinese Academy of Medical Sciences & Peking Union Medical College
2018
Abstract HIV infection exerts profound and long-lasting neurodegenerative effects on the central nervous system (CNS) that can persist despite antiretroviral therapy (ART). Here, we used single-nucleus multiome sequencing to map transcriptomic epigenetic landscapes of postmortem human brains from 13 healthy individuals 20 with who have a history treatment ART. Our study spanned three distinct regions—the prefrontal cortex, insular ventral striatum—enabling comprehensive exploration...
Abstract Principal component analysis (PCA) is indispensable for processing high-throughput omics datasets, as it can extract meaningful biological variability while minimizing the influence of noise. However, suitability PCA contingent on appropriate normalization and transformation count data, accurate selection number principal components; improper choices result in loss information or corruption signal due to excessive Typical approaches these challenges rely heuristics that lack...
After zygotic genome activation and lineage specification, zygotes develop into late blastocysts comprising three distinct cell types. The molecular mechanisms underlying this progress are largely unknown in pigs. Here, we intended to analyze an extensive set of regulators at the single-cell level define events involved development porcine blastocysts. Using a quantitative microfluidics approach single cells, detected mRNA levels 96 genes known function early embryonic maintenance stem...
A new phenolic glycoside named salicyltomenside (1), with five similar compounds, salicyltremuloidin (2), tremuloidin (3), isograndidentatin (4), siebolside B (5), and salicin (6) were isolated from Populus tomentosa Carr.Additionally, (2) was obtained the plant for first time.Structure of compound determined using spectroscopic methods including ESI-MS 1D-and 2D-NMR.Others elucidated through 1 H 13 C NMR spectra comparison literature data.Notably, (1) structural isomers.
Porcine epidemic diarrhea virus (PEDV), an enteric coronavirus, is widely spread worldwide and causes huge economic losses. The effective measure to control the viral infection develop ideal vaccines. Here, monomeric core epitope domain (COE) of PEDV was displayed on surface nanoparticles (NPs) in order a newer, safer more subunit vaccine against PEDV. COE mi3 protein, which self-assembles into composed 60 subunits, using SpyTag/SpyCatcher system. size, Zeta potential, microstructure COE-mi3...
Ginseng (Panax ginseng C. A. Meyer) is an ancient and valuable Chinese herbal medicine, ginsenoside, as the main active ingredient of ginseng, has received wide attention because its various pharmacological effects. Cytochrome P450 largest family enzymes in plant metabolism involved biosynthesis terpenoids, alkaloids, lipids, other primary secondary metabolites. It significant to explore more PgCYP450 genes with unknown functions reveal their roles ginsenoside synthesis. In this study, based...
Abstract Identifying accurate cell markers in single-cell RNA-seq data is crucial for understanding cellular diversity and function. Localized Marker Detector (LMD) a novel tool to identify “localized genes” - genes exclusively expressed groups of highly similar cells thereby characterizing multi-resolution fine-grained manner. LMD constructs cell-cell affinity graph, diffuses the gene expression value across assigns score each based on its diffusion dynamics. LMD’s candidate can be grouped...