A5050480456- Natural Antidiabetic Agents Studies
- Computational Drug Discovery Methods
- Electrochemical sensors and biosensors
- Advanced Nanomaterials in Catalysis
- Advanced biosensing and bioanalysis techniques
- Medicinal Plants and Bioactive Compounds
- Synthesis and biological activity
- Medicinal Plants and Neuroprotection
- Nanoparticles: synthesis and applications
- Phytochemistry and Biological Activities
- Phytochemicals and Antioxidant Activities
- Cholinesterase and Neurodegenerative Diseases
- Cardiac pacing and defibrillation studies
- Electrochemical Analysis and Applications
- Cardiac Structural Anomalies and Repair
- Atrial Fibrillation Management and Outcomes
- Metabolomics and Mass Spectrometry Studies
- Nanocluster Synthesis and Applications
- Cardiac Valve Diseases and Treatments
- Adsorption and biosorption for pollutant removal
- Heart Failure Treatment and Management
- Cardiac Imaging and Diagnostics
- Pericarditis and Cardiac Tamponade
- Cardiac Arrhythmias and Treatments
- Synthesis and Biological Evaluation
Najran University
2020-2024
West Virginia University
2021-2024
Wayne State University
2024
Morgantown High School
2023
Bahria University
2023
Detroit Medical Center
2023
Augusta University Health
2023
Saint Vincent Hospital
2023
University of Georgia
2023
Regional Medical Center
2023
To obtain a multipotent framework that can target simultaneously COX-2, 5-LOX, acetylcholinesterase (AChE), and butyrylcholinesterase (BChE) to treat neuroinflammation, series of derivatives containing pyrimidine pyrrolidine cores were rationally synthesized evaluated. Pyrazoline–pyrimidine hybrid (23g), (3-acetylcoumarin derivative pyrrolidin-1-yl)benzenesulfonamide (27), tacrine (pyrrolidin-1-yl)benzenesulfonamide (31, 38) displayed excellent in vitro COX-2 inhibition having IC50 value the...
Prostrate knotweed also called Polygonum aviculare is an important edible plant. The polygonum majorly known for the phenolics and antioxidants. antioxidants combat excessive free radicals within body. are implicated in various other diseases like diabetes, Alzheimer’s, inflammation. This study was aimed at exploring antioxidant bioactives their derivatizations to produce new molecules with advanced pharmacological features. We have isolated six compounds (1–6) from aviculare. Furthermore,...
Abstract Background According to the recent global cancer statistics, breast is leading cause of deaths among women with 2.3 million new cases globally. Likewise, cervical also causes mortality women. Polygonum hydropiper traditionally known for its cytotoxic effects and several bioactive compounds were isolated from it. This study was aimed isolate potential anticancer most potent fractions evaluate their potentials. Methods Based on our earlier studies, active including chloroform ethyl...
Medicinal plants and essentials oils are well known for diverse biological activities including antidiabetic potential. This study was designed to isolate essential from the leaves of Persicaria hydropiper L. (P. hydropiper), perform its phytochemical analysis, explore in vitro effects.P. (Ph.Los) were extracted using a hydrodistillation apparatus subjected analysis gas chromatography mass spectrometry (GC-MS) technique. Ph.Lo tested against two vital enzymes α-glucosidase α-amylase which...
Natural phenolic compounds and Phenolics-rich medicinal plants are also of great interest in the management diabetes. The current study was aimed to analyze phenolics P. hydropiepr L extracts via HPLC-DAD analysis assess their anti-diabetic potentials using in-vitro in-silico approaches.Plant crude methanolic extract (Ph.Cme) evaluated for presence analysis. Subsequently, samples including (Ph.Cr), hexane (Ph.Hex), chloroform (Ph.Chf), ethyl acetate (Ph.EtAc), butanol (Ph.Bt), aqueous...
Diabetes mellitus is a common disease effecting the lifestyles of majority world population. In this research work, we have embarked potential role crude extracts and isolated compounds Notholirion thomsonianum for management diabetes mellitus.The N. were initially evaluated α-glucosidase, α-amylase antioxidant activities. The from activity based potent solvent fraction. structures confirmed with NMR MS analyses. tested α-amylase, protein tyrosine phosphatase 1B (PTP1B) DPPH molecular...
Organocatalytic asymmetric Michael addition is a strong approach for C-C bond formation. The objective of the study to design molecules by exploiting efficiency Adducts. We proceeded with synthesis adducts tailoring substitution pattern on maleimide and trans-β-nitro styrene as acceptors. synthesized compounds were evaluated dual cyclooxygenases (COX) lipoxygenase (LOX) inhibition.The (4, 9-11) through additions. (COX-1 2) (5-LOX) assays used in vitro evaluations compounds. After acute...
The study was planned to investigate the phytochemicals, antidiabetic and antioxidant studies of A. consanguineum.The preliminary were performed on crude extract different solvent fractions. Based potency, chloroform fraction semi-purified phyto-fractions CHF-1 - 5. Furthermore, CHF-3 subjected isolation pure compounds using column chromatography. α-glucosidase, α-amylase assays (DPPH, ABTS, H2O2) all samples. in-vivo experiments 1 2 also oral glucose tolerance test. Docking α-glucosidase...
Pericardial effusion requiring percutaneous or surgical-based intervention remains an important complication of a leadless pacemaker implantation.