A5020802345- SARS-CoV-2 and COVID-19 Research
- COVID-19 Clinical Research Studies
- Immunodeficiency and Autoimmune Disorders
- COVID-19 epidemiological studies
- SARS-CoV-2 detection and testing
- Dermatological and COVID-19 studies
- Diverse Scientific Research Studies
- Cardiac Arrest and Resuscitation
- Caveolin-1 and cellular processes
- Sepsis Diagnosis and Treatment
- COVID-19 diagnosis using AI
- Respiratory Support and Mechanisms
- Immune responses and vaccinations
- Cell Adhesion Molecules Research
- Respiratory viral infections research
- Platelet Disorders and Treatments
- Cystic Fibrosis Research Advances
- Health and Well-being Studies
National Institute Of Blood Disease and Bone Marrow Transplantation
2019-2020
Aga Khan University Hospital
2010
The recent pandemic by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is a global emergency. There large number of asymptomatic cases SARS-CoV-2 that are not reported. Hence, serological evidence SARS-CoV2 antibodies warranted for better estimation the actual infected patients to limit disease spread and get an idea herd immunity.This cross-sectional study conducted from May 2020 July at National Institute Blood Diseases Pakistan. includes healthcare workers (HCWs), community...
BackgroundPrimary Immunodeficiency Disorders (PIDs) are well-known disorders in the West. but recognition and diagnosis of these is challenging developing countries. We present spectrum PIDs seen at a tertiary care center Pakistan, identified using clinical case definitions molecular methods.MethodsA retrospective chart review children suspected to have PID was conducted Aga Khan University Hospital (AKUH) Karachi, Pakistan from 2010 2016. Data on demographics, features, family history...
Leukocyte adhesion deficiency-III (LAD3) is an extremely rare primary immunodeficiency disorder, transmitted with autosomal-recessive inheritance. It caused by genetic alteration in the FERMT3 gene, which leads to abnormal expression of kindlin-3. This cytoplasmic protein highly expressed leukocytes and platelets, acts as important regulator integrin activation. LAD3 has features like bleeding syndrome Glanzmann-type leukocyte deficiency. mutation(s) have not been well characterized...
Background: There is a sharp decline in new SARS-CoV-2 cases Karachi from July onwards; most of them were asymptomatic.Seroconversion rates vary markedly different countries.Previously, 36% seropositivity was reported the adult population this year.The current study conducted to report if seroprevalence has increased and possible role community immunity.Methods: This prospective cross-sectional first second weeks September 2020 at National Institute Blood disease Bone Marrow Transplantation...
Background: There is a sharp decline in newSARS-CoV-2 cases Karachi from July onwards; most of them were asymptomatic. Seroconversion rates vary markedly different countries. Herd immunity for this virus considered to be at 60-70%. Previously, 36% seropositivity was reported the adult population year. The current study conducted report if seroprevalence has reached threshold herd immunity.Methods: This prospective cross-sectional first and second weeks September 2020 National Institute Blood...
Coronaviruses (CoVs) are the largest group of viruses; order is Nidovirales while family Coronaviridae. They further subdivided into four groups, alpha, beta, gamma and delta coronaviruses [1]. These viruses usually cause mild infections but two zoonotic epidemics betacoronaviruses, severe acute respiratory syndrome coronavirus (SARS-CoV) [2] Middle East (MERS-CoV) [3] have occurred in this century, mortality rates 10% for SARS-CoV [4] a very high i.e. 37% MERS-CoV [5].