A5060265604- Pharmacology and Obesity Treatment
- Spine and Intervertebral Disc Pathology
- Sexual function and dysfunction studies
- Hormonal and reproductive studies
- Diabetes Treatment and Management
- Diet and metabolism studies
- Drug Transport and Resistance Mechanisms
- Pharmacogenetics and Drug Metabolism
- Anesthesia and Pain Management
- Menopause: Health Impacts and Treatments
- Opioid Use Disorder Treatment
- Estrogen and related hormone effects
- Urinary Bladder and Prostate Research
- Muscle metabolism and nutrition
- Musculoskeletal pain and rehabilitation
- Pain Management and Opioid Use
- Orthopaedic implants and arthroplasty
- Spinal Hematomas and Complications
- Marriage and Sexual Relationships
- Folate and B Vitamins Research
- Metabolism and Genetic Disorders
- Spinal Fractures and Fixation Techniques
- Spondyloarthritis Studies and Treatments
- Forensic Toxicology and Drug Analysis
- Antioxidant Activity and Oxidative Stress
Albert Einstein College of Medicine
2022-2025
Yale University
2020-2024
The Bronx Defenders
2022-2023
The Spine Institute
2017-2020
Vivus (United States)
2008-2015
Mountain View College
2012-2014
Duke Medical Center
2011
University of Alabama at Birmingham
2011
Birmingham VA Medical Center
2011
Pennington Biomedical Research Center
2011
A 56-week randomized controlled trial was conducted to evaluate safety and efficacy of a controlled-release combination phentermine topiramate (PHEN/TPM CR) for weight loss (WL) metabolic improvements. Men women with class II III obesity (BMI ≥ 35 kg/m(2)) were placebo, PHEN/TPM CR 3.75/23 mg, or 15/92 added reduced-energy diet. Primary end points percent WL proportions patients achieving 5% WL. Secondary included waist circumference (WC), systolic diastolic blood pressure (BP), fasting...
OBJECTIVE To evaluate over 108 weeks the effect of phentermine and topiramate extended release (PHEN/TPM ER) treatment on progression to type 2 diabetes and/or cardiometabolic disease in subjects with prediabetes metabolic syndrome (MetS) at baseline. RESEARCH DESIGN AND METHODS Subanalysis a phase 3, randomized, placebo-controlled, double-blind study overweight/obese (BMI ≥27 ≤45 kg/m2) two or more comorbidities. Subjects were randomized placebo, PHEN 7.5 mg/TPM ER 46 mg (7.5/46), 15 92...
In Brief Objective: Osteoporosis is a significant health problem in postmenopausal women. Consequently, new and effective therapies are being sought to preserve bone mass prevent osteoporosis this population of The objective study was compare the effects lasofoxifene with raloxifene placebo on indices Design: A randomized, double-blind, placebo- active treatment-controlled 2 years duration conducted. Women included 410 women aged 47 74 years. four treatment groups were: 0.25 mg/day, or 1.0...
We evaluated the safety and efficacy of 100 200 mg avanafil for treatment adult males with erectile dysfunction after bilateral nerve sparing radical prostatectomy.This was a double-blind, placebo controlled, parallel group, phase 3 study in age 18 to 70 years history 6 months or more prostatectomy. Patients were randomized (taken 30 minutes before sexual activity) 12 weeks. Primary end points included successful vaginal insertion (Sexual Encounter Profile [SEP] question 2), intercourse...
To prospectively assess the safety and effectiveness of investigational phosphodiesterase 5 inhibitor avanafil to treat erectile dysfunction in men with diabetes mellitus.This 12-week, multicenter, double-blind, placebo-controlled study conducted between December 15, 2008, February 11, 2010, randomized 390 1:1:1 receive avanafil, 100 mg (n=129), 200 (n=131), or placebo (n=130). Coprimary end points assessed changes percentage sexual attempts which were able maintain an erection sufficient...
A retrospective comparative cohort study.To compare outcomes of elective non-obese anterior cervical discectomy and fusion (ACDF) patients with those that underwent bariatric surgery (BS).Morbid obesity (MO) has been associated an increased risk complications following procedures such as ACDF. While pre-emptive BS considered for MO (body mass index [BMI] ≥35 kg/m 2 ), the impact this intervention on BMI its resultant correlation surgical remains limited.The PearlDiver 2010-Q1 2020 MSpine...
Pre-clerkship medical students benefit from practice questions that provide rationales for answer choices. Creating these is a time-intensive endeavor. Therefore, not all multiple choice (MCQ) have corresponding explanations to aid learning. The authors examined artificial intelligence's (AI) potential create high-quality clinical vignette-style MCQs. conducted single-center pre-post intervention survey study in August 2023 assessing 8 pre-clerkship course director (CD) attitudes towards...
Determine the long-term efficacy, safety and tolerability of avanafil, a highly specific, rapidly absorbed phosphodiesterase type 5 inhibitor in male patients with mild to severe erectile dysfunction (ED), or without diabetes.This was 52-week, open-label extension two 12-week, randomised, placebo-controlled, phase 3 trials. Patients were assigned avanafil 100 mg, but could request 200 mg (for increased efficacy; '100/200-mg' group) 50 improved tolerability). Primary end points included...
YouTube is the most popular video-based source of information on Internet. It accessed by over 1 billion users, which approximates to almost one-third all Internet users. Orthopaedic video content published not screened and does go through an editorial process, videos do have about authorship or appropriate references. Users who knowledge assess accuracy reliability may be misinformed their medical condition. Previous studies evaluated quality for in orthopaedics such as meniscus, kyphosis,...
To investigate the safety and efficacy of a transdermal estradiol (E2) spray in women with postmenopausal vasomotor symptoms.A randomized, double-blind, placebo-controlled, multicenter, parallel-group clinical trial was conducted. Postmenopausal (N=454) at least eight moderate-to-severe hot flushes per day applied daily, one, two, or three E2 (90 microliter contains 1.53 mg E2) matching placebo sprays. The primary endpoints were mean change from baseline frequency severity weeks 4 12.All...
No AccessJournal of UrologyAdult Urology1 Aug 2015Efficacy Avanafil 15 Minutes after Dosing in Men with Erectile Dysfunction: A Randomized, Double-Blind, Placebo Controlled Study Wayne J.G. Hellstrom, Jed Kaminetsky, Laurence H. Belkoff, Irwin Goldstein, James P. Tursi, Jonathan Uy, Craig A. Peterson, Charles Bowden, and Wesley W. Day HellstromWayne Hellstrom Tulane University School Medicine, New Orleans, Louisiana Financial interest and/or other relationship Auxilium. More articles by this...
Arthroscopic rotator cuff repair (ARCR) is a common procedure that typically requires opioid prescription for postoperative pain management.
Optimization of a previously disclosed sorbitol dehydrogenase inhibitor (SDI, II) for potency and duration action was achieved by replacing the metabolically labile N,N-dimethylsulfamoyl group with variety heterocycles. Specifically, this effort led to series novel, in vitro potent SDIs longer serum half-lives acceptable vivo activity acutely diabetic rats (e.g., 62, 67, 69). However, desired chronically rats, ED(90) < or = 5 mg/kg/day, only through further modification piperazine linker....