A5002301946- Zebrafish Biomedical Research Applications
- Nitric Oxide and Endothelin Effects
- Acoustic Wave Resonator Technologies
- Health and Medical Research Impacts
- Ultrasonics and Acoustic Wave Propagation
- Cancer, Lipids, and Metabolism
- Nanoplatforms for cancer theranostics
- Cannabis and Cannabinoid Research
- Cancer, Stress, Anesthesia, and Immune Response
- Neuroscience of respiration and sleep
- Quantum Chromodynamics and Particle Interactions
- Pharmaceutical industry and healthcare
- Health Systems, Economic Evaluations, Quality of Life
- Cardiac Ischemia and Reperfusion
- Particle physics theoretical and experimental studies
- Meta-analysis and systematic reviews
- Health Sciences Research and Education
- Atomic and Subatomic Physics Research
- Plasmonic and Surface Plasmon Research
- Forensic Toxicology and Drug Analysis
- Cutaneous Melanoma Detection and Management
- Advanced Sensor and Energy Harvesting Materials
- Metamaterials and Metasurfaces Applications
- Advanced Chemical Physics Studies
- Renin-Angiotensin System Studies
Oxford Instruments (United Kingdom)
2010-2023
University of Oxford
2023
Cornell University
2016-2021
Memorial Sloan Kettering Cancer Center
2013-2021
National Institute on Minority Health and Health Disparities
2020
The Thousand
2019
Oxford Brookes University
2016-2018
Nokia (United Kingdom)
2010-2015
Montana State University
2015
Meharry Medical College
2011
Sensors allow an electronic device to become a gateway between the digital and physical worlds, sensor materials with unprecedented performance can create new applications avenues for user interaction. Graphene oxide be exploited in humidity temperature sensors number of convenient features such as flexibility, transparency suitability large-scale manufacturing. Here we show that two-dimensional nature graphene its superpermeability water combine enable response speed (∼30 ms recovery...
This study deals with the scattering of plane compressional and shear elastic waves incident obliquely on an infinitely long nondissipative cylindrical discontinuity in isotropic solid. Equations whose solutions are coefficients series expressions for scattered derived case at solid cylinder embedded a different medium. From these equations obtained those governing fluid-filled bore, empty bore. In general, when wave either or type is discontinuity, both types produced, process known as...
Graphite was electrochemically exfoliated in mixtures of room temperature ionic liquids and deionized water containing lithium salts to produce functionalized graphenes such an electrochemical exfoliation technique can be directly used making primary battery electrodes with significantly enhanced specific energy capacity.
The possible role of the endothelium in modulating responses to human urotensin‐II (U‐II) was investigated using isolated segments rat thoracic aorta, small mesenteric artery, left anterior descending coronary artery and basilar artery. Human U‐II a potent vasoconstrictor endothelium‐intact aorta (EC 50 =3.5±1.1 n M , R max =103±10% control contraction induced by 60 m KCl 1 μ noradrenaline). However contractile response not significantly altered removal or inhibition nitric oxide synthesis...
Relaxation of the methoxamine‐precontracted rat small mesenteric artery by endothelium‐derived hyperpolarizing factor (EDHF) was compared with relaxation to cannabinoid, anandamide (arachidonylethanolamide). EDHF produced in a concentration‐ and endothelium‐dependent fashion presence N G ‐nitro‐ l ‐arginine methyl ester ( ‐NAME, 100 μ m ) either carbachol (pEC 50 [negative logarithm EC ]=6.19±0.01, R max [maximum response]=93.2±0.4%; n =14) or calcium ionophore A23187 =6.46±0.02, =83.6±3.6%;...
The relative abundances of the fragment ions that result respectively from nuclear decays CH3I125 and C2H5I125 (I125 undergoes electron capture to give Te125) have been measured with a specially designed mass spectrometer. data both studies are similar evidence as follows highly destructive nature decay: (1) Only about 1% Te—hydrocarbon appear remain intact in spite fact these would be expected collected high efficiency; (2) In large number tellurium is found charges 18 an average charge 9;...
The cannabinoid arachidonyl ethanolamide (anandamide) caused concentration‐dependent relaxation of 5‐HT‐precontracted, myograph‐mounted, segments rat left anterior descending coronary artery. This was endothelium‐independent, unaffected by the fatty acid amide hydrolase inhibitor, trifluoromethyl ketone (10 μ M ), and mimicked non‐hydrolysable anandamide derivative, methanandamide. Relaxations to were attenuated receptor antagonist, SR 141716A (3 but AM 251 (1 ) 630 more selective...
Cannabinoids are known to cause coronary vasodilatation and reduce left ventricular developed pressure (LVDP) in isolated hearts although the identity of receptor(s) mediating these responses is unknown. Our objective was pharmacologically characterize cannabinoid receptors cardiac endocannabinoid, anandamide. Dose‐response curves for perfusion (CPP) LVDP were constructed anandamide, R‐(+)‐methanandamide, palmitoylethanolamide (PEA) JWH015 Langendorff‐perfused rat hearts. Anandamide...
Close-packed monolayers of 20 nm Au nanoparticles are self-assembled at hexane/water interfaces and transferred to elastic substrates. Stretching the resulting nanoparticle mats provides active reversible tuning their plasmonic properties, with a clear polarization dependance. Both uniaxial biaxial strains induce strong blue shifts in resonances. This matches theoretical simulations indicates that coupling nanometer scale distances is responsible for observed spectral tuning. Such...
ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTAcoustic Wave MicrosensorsJay W. Grate, Stephen J. Martin, and Richard M. WhiteCite this: Anal. Chem. 1993, 65, 21, 940A–948APublication Date (Print):November 1, 1993Publication History Published online31 May 2012Published inissue 1 November 1993https://pubs.acs.org/doi/10.1021/ac00069a728https://doi.org/10.1021/ac00069a728research-articleACS PublicationsRequest reuse permissionsArticle Views980Altmetric-Citations165LEARN ABOUT THESE METRICSArticle...
The actions of a number cannabinoid receptor ligands were investigated using the myograph‐mounted rat isolated mesenteric artery. Anandamide, CP 55,940, HU‐210, palmitoylethanolamide and WIN 55,212‐2 all caused concentration‐dependent relaxations methoxamine‐precontracted vessels which not affected by removal endothelium. Precontracting with 60 m M KCl instead methoxamine greatly reduced vasorelaxant effects anandamide palmitoylethanolamide. High K + solution modest decrease in relaxant...
The actions of the cannabinoid receptor antagonist, SR 141716A, were examined in rat isolated mesenteric arteries. At concentrations greater than 3 μ M , it caused concentration‐dependent, but endothelium‐independent, relaxations both methoxamine‐ and 60 m KCl‐precontracted vessels. 141716A (at 10 not at 1 ) inhibited contractions to Ca 2+ methoxamine‐stimulated arteries previously depleted intracellular stores. Neither concentration affected phasic induced by methoxamine absence...
Deletion of caudal/cdx genes alters hox gene expression and causes defects in posterior tissues hematopoiesis. Yet, the only partially explain these phenotypes. To gain deeper insight into Cdx4 function, we performed chromatin immunoprecipitation sequencing (ChIP-seq) combined with gene-expression profiling zebrafish, identified transcription factor spalt-like 4 (sall4) as a target. ChIP-seq revealed that Sall4 bound to its own locus cdx4 locus. Expression showed coregulate initiate...
Objectives Authors may choose to work with professional medical writers when writing up their research for publication. We examined the relationship between support and quality timeliness of reporting results randomised controlled trials (RCTs). Design Cross-sectional study. Study sample Primary reports RCTs published in BioMed Central journals from 2000 16 July 2014, subdivided into those (n=110) without (n=123). Main outcome measures Proportion items that were completely reported a...
The purpose of this study was to examine the mechanism enhanced endothelium-dependent dilation in arteries from female rats compared with males. Isolated mesenteric resistance ( approximately 250 microm) sexually mature male and Sprague-Dawley were pressurized outer diameter measured. Arteries females more sensitive vasodilator acetylcholine (Ach) those males (-log EC(50): = 6.74 +/- 0.06; 6.96 P =.037). After incubation N(omega)-nitro-L-arginine (100 microM) or apamin (30 nM), there no...
ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTAcoustic wave microsensors. Part IIJay W. Grate, Stephen J. Martin, and Richard M. WhiteCite this: Anal. Chem. 1993, 65, 22, 987A–996APublication Date (Print):November 15, 1993Publication History Published online22 September 2008Published inissue 15 November 1993https://pubs.acs.org/doi/10.1021/ac00070a002https://doi.org/10.1021/ac00070a002research-articleACS PublicationsRequest reuse permissionsArticle Views645Altmetric-Citations73LEARN ABOUT...
Abstract The purpose of these studies was to compare changes in conduit and resistance artery function deoxycorticosterone-salt hypertensive rats. We hypothesized that if there a common mechanism producing vascular hypertension, then would be similar alterations reactivity arteries. Helically cut strips carotid were prepared for measurement isometric force generation, segments small mesenteric arteries pressurized video dimension analysis. Sensitivity phenylephrine acetylcholine determined....
We report how the energy capacity and dynamic response of a battery can be modified by changing graphene nanoarchitecture.
An ultrathin layer of metasurface that almost completely annihilates the reflection light (>99.5%) over a wide range incident angles (>80°) is experimentally demonstrated. Such zero‐reflectance metafilms exhibit optimal performance for plasmonic sensing, since their sensitivity to changes local refractive index far superior films nonzero reflectance. Since both main detection mechanisms tracking intensity and wavelength shifts are improved, localized surface plasmon resonance molecular...
The charged fragments resulting from the decay of CH3I131 have been measured by a specially designed mass spectrometer. In 70% decays, parent ion CH3Xe+ remained intact in direct contrast to CH3T which hardly any CH3He+ was found [A. H. Snell and F. Pleasonton, J. Phys. Chem. 62, 1377 (1958)]. More than 20 other ions were also detected including doubly methyl xenon (CH2Xe)+2. Their relative abundances are discussed terms excitation sudden change nuclear charge, multiple Auger processes cases...
The applicability of the self-reciprocity technique to calibration a reversible compressional wave transducer in solid medium is demonstrated, and method described correcting for electrical loading by source signal generator being calibrated.