A5058810568- Glaucoma and retinal disorders
- Retinal Diseases and Treatments
- Corneal surgery and disorders
- Retinal Imaging and Analysis
- Ocular Surface and Contact Lens
- Corneal Surgery and Treatments
- Intraocular Surgery and Lenses
- Retinal and Macular Surgery
- Cardiovascular Health and Disease Prevention
- Ophthalmology and Eye Disorders
- Angiogenesis and VEGF in Cancer
- Neurological Disorders and Treatments
- Optical Imaging and Spectroscopy Techniques
- Cerebral Venous Sinus Thrombosis
- Retinopathy of Prematurity Studies
- Hemodynamic Monitoring and Therapy
- Proteoglycans and glycosaminoglycans research
- Traumatic Brain Injury and Neurovascular Disturbances
- Ophthalmology and Visual Impairment Studies
- Retinal and Optic Conditions
- Cerebrovascular and Carotid Artery Diseases
- Allergic Rhinitis and Sensitization
- Vascular Malformations Diagnosis and Treatment
- Fibroblast Growth Factor Research
- Microbial metabolism and enzyme function
Universitair Ziekenhuis Leuven
2014-2024
KU Leuven
2015-2024
AIMM Therapeutics (Netherlands)
2015
University of Lisbon
2014
Elevated intra-ocular pressure (IOP) has been identified as a major risk factor for glaucoma. Additionally, extensive literature depicts vascular dysfunction to exist in these patients. However, large ocular blood flow-oriented trial integrate findings the clinical setting is lacking. This study would likely help identify which of data can be used tool screening and disease stratification.Prospective, cross-sectional, case-control hospital-based study. Patients with primary open-angle...
Abstract. Purpose: To determine whether retinal vessel oxygen saturation in patients with glaucoma is associated structural optic disc and nerve fibre layer (RNFL) changes visual field (VF) defects. Methods: Fifty‐nine confirmed were recruited at University Hospitals Leuven. Retinal was measured a noninvasive spectrophotometric oximeter (Oxymap ehf, Reykjavik, Iceland). VF Heidelberg tomographies (HRTs) performed on the same day. Statistical analysis using Student’s t ‐test Pearson’s or...
To assess the use of deep learning (DL) for computer-assisted glaucoma identification, and impact training using images selected by an active strategy, which minimizes labelling cost. Additionally, this study focuses on explainability classifier.This original investigation pooled 8433 retrospectively collected anonymized colour optic disc-centred fundus images, in order to develop a learning-based classifier diagnosis. The labels various models were compared with clinical assessment experts....
<h3>Background</h3> To test whether retinal oxygen metabolism is different in glaucoma patients compared with healthy subjects. <h3>Methods</h3> This was a two-centre study where vessel saturation measured and individuals non-invasive spectrophotometric oximeter. Visual fields were obtained the patients. <h3>Results</h3> No statistical difference found arterioles (p=0.16), venules (p=0.16) arteriovenous (p=0.24) when all (n=74) (n=89). When advanced (visual field mean defect (MD ≥ 10 dB,...
To determine whether ROCK inhibition for the treatment of glaucoma can be improved by using novel, locally acting Rho kinase (ROCK) inhibitors, such as AMA0076, that lower IOP without inducing hyperemia.On-target potency AMA0076 was compared with other inhibitors (Y-27632 and Y-39983) conversion into its functionally inactive metabolite evaluated in rabbit eye tissues. Human trabecular meshwork (HTM) cell morphology, actin filaments, focal adhesion were studied vitro after exposure to...
Discussion of an overlap between specific language impairment (SLI) and autism spectrum disorder (ASD) is on going. The most intriguing both phenotypes the similarity in observed deficits described SLI a subgroup ASD with co-occurring linguistic impairment, ASD-LI. Examining whether similar neuroanatomical substrate underlies this phenotypical overlap, we studied white matter microstructural properties superior longitudinal fascicle (SLF) 19 ASD-LI adolescents (mean age 13.8 ± 1.6 years) 21...
To investigate the efficacy and safety of a single intracameral bevacizumab injection to improve outcome trabeculectomy.A 12-month, prospective, randomised, double-masked, placebo-controlled trial. Patients with medically uncontrolled open-angle glaucoma scheduled for primary trabeculectomy were recruited randomised receive 50 µL either (1.25 mg) or placebo (balanced salt solution) peroperatively. Absolute success was defined as intraocular pressure (IOP) ≤18 mm Hg >5 at least 30% reduction...
To investigate the change in corneal astigmatism after trabeculectomy.Between January and April 2012, patients who underwent a primary trabeculectomy were enrolled this prospective study. We measured visual acuity, automated keratorefractometry, intraocular pressure preoperatively postoperatively at 1, 3, 6 months. Changes quantified using vector analysis described by Cravy. A Friedman test linear model for longitudinal measures used to compare changes refraction pressure. binomial was...
The aim of this study was to elucidate the role lysyl oxidase (LOX) and like (LOXL) 2 in pathologic wound healing after glaucoma surgery. We therefore investigated expression LOX LOXL2 evaluated therapeutic potential anti-LOX (GS-639556, formerly M64) anti-LOXL2 (GS-607601, AB0023) antibodies a rabbit model trabeculectomy.Ocular by immunohistologic staining at different time points trabeculectomy. Treatment with GS-639556 or GS-607601 initiated rabbits immediately trabeculectomy giving both...
PURPOSE.Rho kinase (ROCK) is associated with VEGF-driven angiogenesis, as well inflammation and fibrosis.Therefore, the effect of AMA0428, a novel ROCK inhibitor, was studied in these processes, which highly contribute to pathogenesis neovascular AMD.METHODS.The AMA0428 (0.5-5.0 lM) on human umbilical vein endothelial cells (HUVECs), brain microvascular (HBMECs), pericytes (HBVPs) determined using cell viability (WST-1), apoptosis (caspase 3/7), migration (scratch under-agarose) assays.The...
In reducing intraocular pressure (IOP), Paul (PGI) and Baerveldt (BGI) glaucoma implants are safe effective in patients with glaucoma.
To compare the intraocular pressure (IOP) readings taken by ICare, Pascal dynamic contour tonometer (DCT), and ocular response analyzer (ORA) with those Goldmann applanation (GAT). We sought to evaluate influence of central corneal thickness (CCT) on IOP measurements patients' preferences for four tonometers.In this prospective study, 93 eyes from patients were examined. Patients randomly divided into 4 groups vary order in which tonometers applied. CCT was measured an ultrasound...
(1) To characterize the retrobulbar circulation in patients with optic disc drusen (ODD) using colour Doppler imaging; (2) to explore differences hemodynamics primary open-angle glaucoma (POAG).Retrospective analysis three diagnostic groups: ODD, age-matched healthy controls and age- visual defect-matched POAG. Subjects history of ocular trauma or diseases including vascular-related were excluded. Kruskal-Wallis Spearman's correlation tests performed compare correlations between hemodynamic...
Abstract Excessive post‐operative wound healing with subsequent scarring frequently leads to surgical failure of glaucoma filtration surgery (trabeculectomy). We investigated the hypothesis that placental growth factor (Pl GF ) plays a role in scar formation, and it therefore may be target for improvement outcome. ELISA experiments showed Pl levels were significantly increased aqueous humour patients after VEGF treatment, which indicate an important contribution this trabeculectomy. Using...
Purpose: Diabetic retinopathy (DR) is characterized by an early stage of inflammation and vessel leakage, advanced vasoproliferative stage. Also, neurodegeneration might play important role in disease pathogenesis. The aim this study was to investigate the effect Rho kinase (ROCK) inhibitor, AMA0428, on these processes.Methods: response ROCK inhibition AMA0428 (1 µg) studied vivo using murine model for streptozotocin (STZ)-induced diabetes, focusing non-proliferative DR features...
To characterize Doppler waveform variables (early systolic acceleration [ESA] and systolic/diastolic mean velocity ratios [Sm/Dm]) of the Ophthalmic Artery (OA) by color imaging (CDI) in eyes with primary open-angle glaucoma (POAG).Analysis CDI examinations retrobulbar circulation patients POAG (n = 102), normal tension (NTG, n 89), healthy controls 59) a condition-masked investigator. One-way ANOVA, chi-square, Spearman's rank correlation tests were used to determine differences, establish...