A5103223689- Click Chemistry and Applications
- Essential Oils and Antimicrobial Activity
- Fungal Plant Pathogen Control
- Forensic Toxicology and Drug Analysis
- Sesquiterpenes and Asteraceae Studies
- Advanced NMR Techniques and Applications
- Botanical Research and Applications
- Phytochemistry Medicinal Plant Applications
- Synthesis and biological activity
- Cannabis and Cannabinoid Research
- Synthesis and Biological Evaluation
- Chemical Synthesis and Characterization
- Postharvest Quality and Shelf Life Management
- GABA and Rice Research
- Studies on Chitinases and Chitosanases
- Transgenic Plants and Applications
- Marine Sponges and Natural Products
- Mesoporous Materials and Catalysis
- Seed Germination and Physiology
- Protein Degradation and Inhibitors
Military Institute of Engineering
2024-2025
Universidade Federal do Espírito Santo
2021-2025
Background/Objectives: Andiroba oil, extracted from Carapa guianensis seeds, possesses therapeutic properties including anti-inflammatory and wound healing effects. This study aimed to develop characterize a nanoemulsion formulation containing andiroba oil (NeAnd) evaluate its cytotoxicity potential in vitro. Methods: The was evaluated for acidity, antioxidant activity, fatty acid composition. NeAnd produced by ultrasonication characterized using FTIR (Fourier transform infrared...
Glycogen synthase kinase-3 beta (GSK-3β) plays a crucial role in multiple cellular processes and is implicated different types of cancers neurological disorders, including Alzheimer’s disease. Despite extensive efforts to develop novel GSK-3β inhibitors, the discovery potent selective lead compounds remains challenge. In this study, we evaluated inhibitory potential semisynthetic flavonoid derivatives, which exhibited sub-micromolar activity. To gain further insights, employed molecular...
The semisynthesis of 15 new thymol derivatives was achieved through Williamson synthesis and copper-catalyzed azide–alkyne cycloaddition (CuAAC) approaches. reaction CuAAC using the "Click Chemistry" strategy, in presence an alkynyl derivative commercial or prepared azides, provided nine under microwave irradiation. This procedure reduces time cost. All molecular entities were elucidated by 1H 13C NMR, IR, HRMS data. These evaluated vitro for their fungicidal activity against Fusarium solani...
Trema micranthum (Cannabaceae) has emerged as a promising new source of cannabinoids, including cannabidiol (CBD). Given the substantial medicinal demand for cannabinoids and regulatory challenges associated with Cannabis sativa due to presence Δ9-tetrahydrocannabinol (THC), this study sought explore CBD, THC, their precursors, Δ9-tetrahydrocannabinolic acid A (THCA A) cannabidiolic (CBDA), in various parts using UHPLC-HRMS/MS (Orbitrap). Extracts from fruits, leaves, inflorescences, stems...
Historically, medicinal chemistry has been concerned with the approach of organic for new drug synthesis. Considering fruitful collections molecular entities, dedicated efforts are rewarding. Planning and search applicable pharmacologic therapies involve altruistic nature scientists. Since 19th century, notoriously applying isolated characterized plant-derived compounds in modern discovery various stages clinical development highlight its viability significance. Natural products influence a...
Natural products have been universally approached in the research of novel trends useful to detail essential paths life sciences and as a strategy for pharmacotherapeutics.This work focuses on further modification 6-hydroxy-flavanone building block aiming obtain improved BCR-ABL kinase inhibitors.Ether derivatives were obtained from Williamson synthesis triazole Microwave- assisted click reaction. Chemical structures finely characterized through IR, 1H 13C NMR HRMS. They tested their...