A5082227002- Effects and risks of endocrine disrupting chemicals
- Birth, Development, and Health
- Pancreatic function and diabetes
- Diet and metabolism studies
- Carcinogens and Genotoxicity Assessment
- Renal and related cancers
- Cancer, Hypoxia, and Metabolism
- Erythropoietin and Anemia Treatment
- Diabetes and associated disorders
- Toxic Organic Pollutants Impact
- Reproductive Biology and Fertility
- Pharmacogenetics and Drug Metabolism
Universitat de Miguel Hernández d'Elx
2016-2024
Centro de Investigación Biomédica en Red Diabetes y Enfermedades Metabólicas Asociadas
2016-2022
Alterations during development of metabolic key organs such as the endocrine pancreas affect phenotype later in life. There is evidence that utero or perinatal exposure to bisphenol-A (BPA) leads impaired glucose metabolism adulthood. However, how BPA pregnancy affects pancreatic β-cell growth and function offspring early life has not been explored. We exposed pregnant mice either vehicle (control) (10 100 μg/kg·d, BPA10 BPA100) examined on postnatal days (P) P0, P21, P30, P120. BPA100...
Endocrine-disrupting chemicals (EDCs) are chemical substances that can interfere with the normal function of endocrine system. EDCs ubiquitous and be found in a variety consumer products such as food packaging materials, personal care household products, plastic additives, flame retardants. Over last decade, impact on human health has been widely acknowledged they have associated different diseases. Among them, subset called metabolism-disrupting (MDCs) is able to promote metabolic changes...
Background: Gestational diabetes mellitus (GDM) is the most common metabolic disease during pregnancy and increases prevalence of type 2 in both mothers offspring. GDM management provides a window opportunity to prevent lower global burden across life. Molecular mechanisms underlying are poorly defined. In this study, we explore potential involvement transforming growth factor beta (TGF-β) signaling as pathway has been reported affect pancreatic β-cell development, proliferation identity....
Humans are constantly exposed to many environmental pollutants, some of which have been largely acknowledged as key factors in the development metabolic disorders such diabetes and obesity. These chemicals classified endocrine-disrupting (EDCs) and, more recently, since they can interfere with functions, renamed metabolism-disrupting (MDCs). MDCs present consumer products, including food packaging, personal care plastic bottles containers, detergents. The scientific literature has...
Abstract Endocrine-disrupting chemicals (EDCs) are chemical substances that can interfere with the normal function of endocrine system. EDCs ubiquitous and be found in a variety consumer products such as food packaging materials, personal care household products, plastic additives, flame retardants. Over last decade, impact on human health has been widely acknowledged they have associated different diseases. Among them, subset called metabolism-disrupting (MDCs) able to promote metabolic...
Oxygen (O2 ) rates in the oviduct are essential to human and animal reproduction. These regulated by activity of hypoxia markers such as hypoxia-inducible factors (HIFs), glucose transporters (GLUT), carbonic anhydrase (CA). In porcine model, scarce studies have been reported regarding these their effects reproduction unknown. The objective was characterize immunolocalization HIF-2α, GLUT1, CAIX oviducts throughout estrous cycle. Oviducts (ampulla isthmus) adult sows (n = 45) were collected...
Abstract Bisphenol-A (BPA) is one of the highest volume chemicals produced worldwide. It used as base compound in manufacture polycarbonate plastics, epoxies and resins. Humans are consistently exposed to BPA it has been detected majority individuals examined. Experimental research animals, well human epidemiological studies, converge conclude that a risk factor for development type 2 diabetes. In previous studies we have demonstrated exposure during embryonic promote an increment pancreatic...
El origen de la diabetes mellitus tipo 2 es multifactorial e involucra diversos factores genéticos y medioambientales. Estos últimos incluyen a los contaminantes químicos ambientales llamados disruptores endocrinos. bisfenol-A (BPA) un disruptor endocrino que actúa fundamentalmente mimetizando estrógenos, uniéndose activando receptores estrógenos ERalfa ERbeta (ER ER ). La exposición BPA durante gestación altera homeostasis glucosa en descendientes. Los principales cambios observados se...
Abstract Humans are constantly exposed to many environmental pollutants, some of which have been largely acknowledged as key factors in the development metabolic disorders such diabetes and obesity. These chemicals classified endocrine-disrupting (EDCs) and, more recently, since they can interfere with functions, renamed metabolism-disrupting (MDCs). MDCs present consumer products, including food packaging, personal care plastic bottles containers, detergents. The scientific literature has...