A5033289594- Acute Lymphoblastic Leukemia research
- Estrogen and related hormone effects
- Antifungal resistance and susceptibility
- Ovarian cancer diagnosis and treatment
- Fungal Infections and Studies
- Sarcoma Diagnosis and Treatment
- Bone Tumor Diagnosis and Treatments
- Pharmacogenetics and Drug Metabolism
- Childhood Cancer Survivors' Quality of Life
- Radiopharmaceutical Chemistry and Applications
- Acute Myeloid Leukemia Research
- Neuroendocrine Tumor Research Advances
- Neutropenia and Cancer Infections
- Cancer, Hypoxia, and Metabolism
- Bone and Joint Diseases
- Endometrial and Cervical Cancer Treatments
- Endometriosis Research and Treatment
- Muscle and Compartmental Disorders
- Chromatin Remodeling and Cancer
- Cardiac electrophysiology and arrhythmias
- Methemoglobinemia and Tumor Lysis Syndrome
- Synthesis and Biological Evaluation
- Steroid Chemistry and Biochemistry
- Adolescent and Pediatric Healthcare
- Cystic Fibrosis Research Advances
Aristotle University of Thessaloniki
2010-2024
AHEPA University Hospital
2005-2019
Hippocration General Hospital
2013-2016
Theageneio General Hospital
1987-2012
National and Kapodistrian University of Athens
2004-2007
Papageorgiou General Hospital
2005-2006
Hellenic Agency for Local Development and Local Government
2005
Institut Claudius Regaud
2004
Memorial Sloan Kettering Cancer Center
2004
Weatherford College
2004
Inhibitors of acetylcholine breakdown by acetylcholinesterase (AChE) constitute the main therapeutic modality for Alzheimer's disease. In search natural products with inhibitory action on AChE, this study investigated activity saffron extract and its constituents in vitro enzymatic molecular docking studies. Saffron has been used traditional medicine against showed moderate AChE (up to 30%), but IC(50) values crocetin, dimethylcrocetin, safranal were 96.33, 107.1, 21.09 μM, respectively....
The aim of this prospective, randomised, open-label, blinded-end point study was to compare the efficacy and safety eplerenone versus spironolactone in patients with bilateral idiopathic hyperaldosteronism (IHA). After a 2-week washout period, 34 IHA were assigned receive either 25 mg b.i.d. (n = 17) or for 24 weeks. If patients' blood pressure (BP) not < 140/90 mmHg, doses gradually increased up 400 200 eplerenone. BP remained uncontrolled, daily dose hydrochlorothiazide 12.5 added at week...
High, normal and poor responders are usually defined by reference to subjectively selected estradiol E2 levels at days 4-6 the day of hCG administration (d-hCG). The purpose this study was use percentile curves from 5 until d-hCG determine high, responders, predict IVF outcome.In retrospective study, 762 patients underwent 905 cycles with a GnRH agonist/recombinant FSH short protocol. They were divided into three groups according their age. Percentile plotted. High those above 90th...
The metabolic syndrome is a cluster of potent risk factors for cardiovascular diseases. To provide information on the late complications chemotherapy acute lymphoblastic leukemia (ALL), authors prospectively studied frequency overweight, obesity, and in survivors ALL initial years after completion therapy. Children adolescents were classified as having if they met three or more following criteria: hypertriglyceridemia, low levels high-density lipoprotein (HDL), high fasting glucose,...
Abstract Background and aim: Rhabdomyosarcoma is the commonest malignant tumour of nose paranasal sinuses in paediatric population. Due to its rarity largely unknown biological behaviour, treatment this complex controversial. We present results multimodality sinonasal rhabdomyosarcoma, we explore role surgery management malignancy. Methods: retrospectively reviewed records 14 patients (median age 7.5 years) with rhabdomyosarcoma. Six underwent major post-operative chemoradiation. Eight...
We aimed to investigate whether the presence of mannose binding lectin (MBL2), ficolin 2 (FCN2) polymorphisms or combined deficiency significantly influence risk and subsequently frequency chemotherapy-induced bacterial infections in children with B acute lymphoblastic leukemia (B-ALL).MBL2 for exon 1 FCN2 promoter regions -986, -602, -557, -64, -4 8 +6,359, +6,424 were determined B-ALL. haplotype was by gene sequencing. Number duration FN episodes as well number recorded during induction...
Optimal sexual function after surgical correction of clitoral hypertrophy requires an adequate postoperative innervation and vascular supply to the glans clitoris. Several clitoroplasty methods have been reported, but few describe preservation dorsal ventral neurovascular bundles in sexually mature women.A 22-year-old woman with clitoromegaly caused by non-salt-wasting classic 21-hydroxylase deficiency presented for a second procedure operation her infancy. The erect length exceeded 7.5 cm....
Extraskeletal Ewing sarcoma (EES) represents a rare soft tissue malignant neoplasm histologically similar to skeletal sarcoma. It occurs mainly in adolescents and young adults commonly affects the paravertebral regions. The differential diagnosis includes other small, blue round cells tumors. authors report case of an EES involving spinal epidural spaces adolescent boy. was confirmed by features histologic analysis immunohistochemistry presence t(11;22)(q24;q12) chromosomal translocation...
Transient myeloproliferative disorder is a hematologic abnormality characterized by an uncontrolled proliferation of myeloblasts in peripheral blood and bone marrow that primarily affects newborns babies with Down syndrome. Tumor lysis syndrome rarely associated transient disorder.Transient was diagnosed seven-day-old baby girl syndrome, who referred to our department due hyperleukocytosis. Our patient developed tumor successfully treated rasburicase, as complication resulting from rapid...
We investigated the relation between diabetic autonomic neuropathy (DAN) and left ventricular (LV) function in 59 patients with type 2 diabetes mellitus (T2DM) free of coronary artery disease (CAD) or hypertension. Diabetic was established by ≥2 abnormal nervous tests. Left systolic diastolic functions were assessed resting radionuclide ventriculography. Compared non-DAN (n = 24), DAN 35) had an increased adjusted atrial contribution to filling (A/V%, 30.1% ± 8.2% vs 26.5% 5.1%; P .031),...
Key Clinical Message We report a case of spinal epidural hematoma ( SEH ) preceded by diagnostic lumbar puncture LP in 5‐year‐old boy with acute lymphoblastic leukemia. MRI confirmed the presence between T7 and L5 levels, but patient showed fast recovery during next hours conservative management was elected.
Octreotide is a synthetic somatostatin analogue which has been suggested for use in the management of acute pancreatitis, though its safety and effectiveness pediatric setting not extensively studied. we present rare case 6.5-year-old female with lymphoblastic leukemia (ALL) L-asparaginase (L-asp) induced who developed epileptic seizures, possibly associated octreotide administration. Her imaging laboratory findings ruled out leukemic involvement or infection CNS. The EEG revealed repetitive...