A5059314345- Cancer therapeutics and mechanisms
- Crystallization and Solubility Studies
- X-ray Diffraction in Crystallography
- Neuroendocrine Tumor Research Advances
- Cancer Immunotherapy and Biomarkers
- Genomics, phytochemicals, and oxidative stress
- Histone Deacetylase Inhibitors Research
- Cancer Treatment and Pharmacology
- Lung Cancer Research Studies
- Estrogen and related hormone effects
- Synthesis and biological activity
- Metal complexes synthesis and properties
- Bone health and treatments
- Thyroid Cancer Diagnosis and Treatment
- Computational Drug Discovery Methods
- Epigenetics and DNA Methylation
- Pharmacogenetics and Drug Metabolism
- Colorectal Cancer Treatments and Studies
- DNA Repair Mechanisms
- Synthesis and Characterization of Heterocyclic Compounds
- Neuroblastoma Research and Treatments
- Thyroid Disorders and Treatments
- Click Chemistry and Applications
- Cancer Genomics and Diagnostics
- Lung Cancer Treatments and Mutations
National and Kapodistrian University of Athens
2016-2025
Henry Dunant Hospital
2009-2021
Theageneio General Hospital
2005-2017
Metaxa Hospital
2005-2009
University of Patras
2003-2007
401 General Military Hospital of Athens
2005
National Centre of Scientific Research "Demokritos"
1995-1997
Inhibitors of acetylcholine breakdown by acetylcholinesterase (AChE) constitute the main therapeutic modality for Alzheimer's disease. In search natural products with inhibitory action on AChE, this study investigated activity saffron extract and its constituents in vitro enzymatic molecular docking studies. Saffron has been used traditional medicine against showed moderate AChE (up to 30%), but IC(50) values crocetin, dimethylcrocetin, safranal were 96.33, 107.1, 21.09 μM, respectively....
<i>Objective:</i> The objective of this phase III trial was to compare chemotherapy combined with bevacizumab versus alone in the treatment patients advanced colorectal cancer. <i>Methods:</i> From September 2004 till 2008, 222 treatment-naive were enrolled and divided into 2 arms: 114 arm A treated leucovorin, 5-fluorouracil plus irinotecan combination bevacizumab, 108 B as above without bevacizumab. All stage IV histologically confirmed adenocarcinoma....
Migraine is a chronic, debilitating neurological disorder affecting billions worldwide. While not life-threatening, migraine patients experience significant unmet needs in diagnosis and management. Addressing these challenges could result improvement of patient outcomes reduction the socioeconomic burden imposes on individuals, healthcare system society. This survey aimed to capture Greece perspective medical experts (neurologists) specializing management regarding treatment. An online...
Migraine is a chronic, debilitating neurological disease affecting more than 1 billion patients, worldwide. Even though migraines are not life-threatening, they have profound effects on individuals, families, and society. The aim of this study was to describe patients' perspectives socioeconomic humanistic burden migraine, as well the unmet medical needs in clinical management Greece. A mixed design Delphi panel focus group conducted, which 16 9 episodic migraine patients from two Greek...
Background: In the present study, we aimed to characterize cytotoxic efficacy of Zebularine either as a single agent or in combination with various isothiocyanates an vitro model consisting human melanoma (A375, Colo-679) well non-tumorigenic immortalized keratinocyte (HaCaT) cells. Methods: this model, have evaluated anti-melanoma effect (in and combinatorial protocols) terms cell viability, apoptotic induction alterations ultrastructural chromatin configuration, protein expression levels...
The development of new antitumor agents is one the most pressing research areas in medicinal chemistry and medicine. importance triazole thiadiazole rings as scaffolds present a wide range therapeutic has been well reported driven synthesis large number novel agents. presence these heterocycles furnishes extensive synthetic possibilities due to several reaction sites. Prompted by data we designed, synthesized evaluated series 3,6-disubstituted 1,2,4-triazolo-[3,4-b]-1,3,4-thiadiazole...
Penile squamous cell carcinoma (PeSCC) is a rare tumor and advanced PeSCC associated with poor survival due to the aggressiveness of disease lack effective systemic therapies. We describe for first time case chemoradiation refractory who had documented response active immunotherapy immune checkpoint inhibitor, anti-programmed death-1 monoclonal antibody Nivolumab. The patient suffered from prognosis human papillomavirus-negative PeSCC, somatic inactivation mutation cyclin-dependent kinase...
In this study, we utilized an in vitro model consisting of human malignant melanoma as well non-tumorigenic immortalized keratinocyte cells with the aim characterizing therapeutic effectiveness clinical epigenetic drug Tazemetostat alone or combination various isothiocyanates. doing so, assessed markers cell viability, apoptotic induction, and expression levels key proteins capable mediating response. Our data indicated, for first time, that caused a significant decrease viability dose-...
Isothiocyanates (ITCs) are biologically active plant secondary metabolites capable of mediating various biological effects including modulation the epigenome. Our aim was to characterize effect allyl isothiocyanate (AITC) on lysine acetylation and methylation marks as a potential epigenetic-induced anti-melanoma strategy. malignant melanoma model consisted (1) human (A375) murine (B16-F10) well human; (2) brain (VMM1) lymph node (Hs 294T) metastatic melanoma; (3) non-melanoma epidermoid...
Watercress is an enriched source of phenethyl isothiocyanate (PEITC), among other phytochemicals, with antioxidant capacity. The aim this study was to (i) chemically characterize and (