A5030700585- Reproductive Biology and Fertility
- Sperm and Testicular Function
- Ovarian function and disorders
- Assisted Reproductive Technology and Twin Pregnancy
- Reproductive Health and Technologies
- Endometriosis Research and Treatment
- Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities
- Prenatal Screening and Diagnostics
- Renal and related cancers
- Sexual Differentiation and Disorders
- Reproductive System and Pregnancy
- Animal Genetics and Reproduction
- Gynecological conditions and treatments
- HIV/AIDS Research and Interventions
- Uterine Myomas and Treatments
- Tissue Engineering and Regenerative Medicine
- Hemoglobinopathies and Related Disorders
- Cystic Fibrosis Research Advances
- Genetic and Kidney Cyst Diseases
- LGBTQ Health, Identity, and Policy
- Genomic variations and chromosomal abnormalities
- Pluripotent Stem Cells Research
- CRISPR and Genetic Engineering
- Genetic Syndromes and Imprinting
- Chromosomal and Genetic Variations
Université Paris Cité
2016-2025
Hôpital Cochin
2009-2025
Assistance Publique – Hôpitaux de Paris
2016-2025
Institut Cochin
2012-2025
Inserm
2009-2025
Sorbonne Paris Cité
2015-2025
Groupe Hospitalier Cochin - Port-Royal, Hôtel-Dieu, Broca - La Collégiale
2001-2025
Maternité Port Royal
1999-2024
Centre National de la Recherche Scientifique
2012-2024
FHU Neurovasc
2022
Sex chromosome dosage compensation is essential in most metazoans, but the developmental timing and underlying mechanisms vary significantly, even among placental mammals. Here we identify human-specific regulating X activity early embryonic development. Single-cell RNA sequencing imaging revealed co-activation accumulation of long noncoding RNAs (lncRNAs) XACT XIST on active chromosomes both human pre-implantation embryos naive stem cells. In these contexts, adopts an unusual, highly...
In mammals, X-chromosome dosage compensation is achieved by inactivating one of the two X chromosomes in females. mice, inactivation initially imprinted, with paternal (Xp) chromosome occurring during preimplantation development. One theory that Xp preinactivated female embryos, because its previous silence meiosis male germ line. The extent to which active after fertilization and exact time onset X-linked gene silencing have been subject debate. We performed a systematic, single-cell...
Background Assisted Reproductive Technologies (ART) are increasingly used in humans; however, their impact is now questioned. At blastocyst stage, the trophectoderm directly contact with an artificial medium environment, which can placental development. This study was designed to carry out in-depth analysis of transcriptome after ART mice. Methodology/Principal Findings Blastocysts were transferred either (1) vivo fertilization and development (control group) or (2) vitro embryo culture....
Abstract Asthenozoospermia, defined by the absence or reduction of sperm motility, constitutes most frequent cause human male infertility. This pathological condition is caused morphological and/or functional defects flagellum, which preclude proper progression. While in last decade many causal genes were identified for asthenozoospermia associated with severe flagellar defects, causes purely are still poorly defined. We describe here case an infertile man, displaying without major anomalies...
Do women with endometriosis who achieve a live birth (LB) after HRT-frozen embryo transfer (HRT-FET) have different progesterone levels on the day of compared to unaffected women?
High, normal and poor responders are usually defined by reference to subjectively selected estradiol E2 levels at days 4-6 the day of hCG administration (d-hCG). The purpose this study was use percentile curves from 5 until d-hCG determine high, responders, predict IVF outcome.In retrospective study, 762 patients underwent 905 cycles with a GnRH agonist/recombinant FSH short protocol. They were divided into three groups according their age. Percentile plotted. High those above 90th...
Are ICSI outcomes impaired in cases of severe asthenozoospermia with multiple morphological abnormalities the flagellum (MMAF phenotype)?Despite occasional technical difficulties, for couples MMAF do not differ from those other requiring ICSI, irrespective genetic defect.Severe asthenozoospermia, especially when associated phenotype, results male infertility. Recent findings have confirmed that a aetiology is frequently responsible this phenotype. In such situations, pregnancies can be...
Abstract STUDY QUESTION Which factors are associated with low serum progesterone (P) levels on the day of frozen embryo transfer (FET), in HRT cycles? SUMMARY ANSWER BMI, parity and non-European geographic origin P FET cycles. WHAT IS KNOWN ALREADY The detrimental impact concentrations HRT-FET outcomes is commonly recognized. However, accounting for level disparities among patients receiving same luteal phase support treatment remain to be elucidated, help clinicians predicting which...
To evaluate the satisfaction of patients accompanied by hypnosis during oocyte retrieval under local anesthesia. This cohort study included undergoing anesthesia with hypnotic support provided either a hypnotherapist or via virtual reality headset between November 2022 and 2023. A questionnaire was distributed after procedure, assessing for pain anxiety management, as well experience (visual analog scale) (State-Trait Anxiety Inventory) procedure. Incomplete questionnaires...
Do serum estradiol (E2) levels on the day of frozen blastocyst transfer (FBT) affect pregnancy outcomes in hormonal replacement therapy (HRT) cycles using transdermal estrogens? E2 ≥313 pg/ml FBT are associated with increased early miscarriage rates (EMRs), but do not significantly impact live birth rate (LBR). plays a crucial role endometrial receptivity and placentation. The effect measured around time HRT remains debated, some studies indicating negative high others finding no significant...
Abstract STUDY QUESTION How does adenomyosis affect live birth rates (LBRs) in women undergoing ART compared to a matched control population? SUMMARY ANSWER Women with adenomyosis, controls for age, blastocyst count, and top-quality exhibited reduced LBR following IVF/ICSI treatment. WHAT IS KNOWN ALREADY Adenomyosis, benign uterine disorder, is believed hinder implantation due anatomical, hormonal, immune disruptions. Its precise impact on LBRs ART, however, remains controversial, studies...