A5007315311- Tuberculosis Research and Epidemiology
- Synthesis and biological activity
- Cancer therapeutics and mechanisms
- Phenothiazines and Benzothiazines Synthesis and Activities
- Dermatology and Skin Diseases
- Advancements in Transdermal Drug Delivery
- Antibiotic Resistance in Bacteria
- Bioactive Compounds and Antitumor Agents
- Mycobacterium research and diagnosis
- Computational Drug Discovery Methods
- Pneumocystis jirovecii pneumonia detection and treatment
- Papaya Research and Applications
- Microbial Natural Products and Biosynthesis
- Herbal Medicine Research Studies
- Drug-Induced Adverse Reactions
- Metal complexes synthesis and properties
- Phytochemistry and Biological Activities
- Essential Oils and Antimicrobial Activity
- Ethnobotanical and Medicinal Plants Studies
- Natural product bioactivities and synthesis
- Sesquiterpenes and Asteraceae Studies
- Diverse Scientific Research Studies
- Malaria Research and Control
- Trace Elements in Health
- Pharmacological Effects of Natural Compounds
Stellenbosch University
2012-2021
South African Medical Research Council
2015-2019
National Institute of Research in Tuberculosis
2017
University of Cape Town
2011
ABSTRACT New drugs to treat drug-resistant tuberculosis are urgently needed. Extensively and probably the totally strains resistant fluoroquinolones like moxifloxacin, which target gyrase A, most people infected with these die within a year. In this study, we found that novel aminobenzimidazole, VXc-486, targets B, potently inhibits multiple drug-sensitive isolates of Mycobacterium in vitro (MICs 0.03 0.30 μg/ml 0.08 5.48 μg/ml, respectively) reduces mycobacterial burdens lungs mice vivo ....
To investigate the effect of trimethoprim/sulfamethoxazole on survival Mycobacterium tuberculosis and trimethoprim sulfamethoxazole individually combined with first-line drugs (isoniazid, rifampicin ethambutol). M. strains were exposed to either combination or alone at various concentrations. The also in existing antibiotics assess growth BACTEC 460TB system. was compared vehicle-treated controls. Drug interactions interpreted using quotient values obtained from index cultures treated a...
Abstract The observations that the innate immune system employs copper to eliminate bacterial infection and resistance enhances virulence of Mycobacterium tuberculosis ( Mtb ) prompted us examine effects anti‐cancer agent elesclomol on . As a bis‐thionohydrazide, chelates with form complex in situ via redox cycling metal ion greatly oxidative stress tumour cells. Here, we demonstrate is relatively potent against H37Rv minimum inhibitory concentration 10 μM (4 mg/L) multidrug resistant...
A series of 2(5H)-furanone-based compounds were synthesized from commercially available mucohalic acids. From the first-generation compounds, three showed inhibitory activity (10 µg/mL) at least 35% against Mycobacterium smegmatis mc2 155 growth (Bioscreen C system). In screening active for inhibition tuberculosis H37Rv, most compound was identified with a minimum concentration (MIC99) 8.07 µg/mL (15.8 µM) using BACTEC 460 system. No cross-resistance observed some current first-line anti-TB...
Abstract To evaluate the feasibility of developing drugs that may be active against both malaria and tuberculosis (TB) by using in part putative cholesterol transporters causative pathogens through enhancement passive diffusion granulomatous TB, artemisinin–cholesterol conjugates were synthesized connecting component molecules various linkers. The compounds screened vitro Plasmodium falciparum ( Pf ) Mycobacterium Mtb ). Antimalarial activities (IC 50 drug‐sensitive NF54, drug‐resistant K1...
Background: The emergence of drug-resistant strains Mycobacterium tuberculosis has become a global public health problem. Polyherbal medicines offer great hope for developing alternative drugs the treatment tuberculosis.Objective: To evaluate anti-tubercular activity polyherbal used tuberculosis.Methods: remedies were screened against H37Rv using Middlebrook 7H9 media and MGIT BACTEC 960 system. They liquid preparations from King Williams Town site A (KWTa), B (KWTb), C (KWTc), Hogsback...
A series of novel riminophenazine derivatives, having ionizable alkyl substituents at N-5 and a variety on the C-3 imino nitrogen, C-8 pendant aryl group, have been designed synthesized. Preliminary investigations into relationship between lipophilicity, redox potential, antimycobacterial activity were conducted, using in vitro against Mycobacterium tuberculosis H37Rv, mammalian cytotoxicity, potential compounds determined by cyclic voltammetry as measures. Results revealed an “cliff”...