A5072441425- Bioinformatics and Genomic Networks
- Autopsy Techniques and Outcomes
- Genomics and Phylogenetic Studies
- Health disparities and outcomes
- Cancer, Lipids, and Metabolism
- Computational Drug Discovery Methods
- Machine Learning in Bioinformatics
- Health and Conflict Studies
- Epigenetics and DNA Methylation
- Plant tissue culture and regeneration
- Genomics and Chromatin Dynamics
- RNA modifications and cancer
- Global Cancer Incidence and Screening
- RNA Research and Splicing
- Biomedical Text Mining and Ontologies
- Gene expression and cancer classification
South African Medical Research Council
2022-2024
University of the Western Cape
2008-2010
National University Health System
2008
Prostate cancer (PC) is one of the most commonly diagnosed cancers in men. PC relatively difficult to diagnose due a lack clear early symptoms. Extensive research has led availability large amount data on PC. Several hundred genes are implicated different stages PC, which may help developing diagnostic methods or even cures. In spite this accumulated information, effective diagnostics and treatments remain evasive. We have developed Dragon Database Genes associated with Cancer (DDPC) as an...
Ovarian cancer (OC) is becoming the most common gynecological in developed countries and lethal malignancy. It also fifth leading cause of all cancer-related deaths women. The identification diagnostic biomarkers development early detection techniques for OC largely depends on understanding complex functionality regulation genes involved this disease. Unfortunately, information about these scattered throughout literature various databases making extraction relevant functional a task. To...
Verbal autopsy (VA), though imperfect, serves as a vital tool to determine cause-of-death, particularly for out-of-facility deaths, but challenges persist in integrating VA into Civil Registration and Vital Statistics systems.
Coordinated transcriptional modulation of large gene sets depends on the combinatorial use cis-regulatory motifs in promoters. We postulate that promoter content similarities are diagnostic for co-expressing genes function coherently during specific cellular responses. To find we propose an ab initio method identifies motif families promoters target groups, map these to all genome, and determine best matches each group with other When was tested rice starting from a Late Embryogenesis...
<title>Abstract</title> <bold>Background</bold> The quality of cause death (COD) statistics in South Africa has room for improvement. It is possible that supplementary use verbal autopsy (VA) interviews the deaths occur outside health facilities might be useful. This study describes challenges and successes collecting a national sample VA interviews. <bold>Methods</bold> We recruited next kin who registered 27 randomly sampled sub-districts across between September 2017 – April 2018. Trained...