A5082467242- Assisted Reproductive Technology and Twin Pregnancy
- Pregnancy and preeclampsia studies
- Preterm Birth and Chorioamnionitis
- Reproductive System and Pregnancy
- Prenatal Screening and Diagnostics
- Neonatal Respiratory Health Research
- Birth, Development, and Health
- Genetics and Neurodevelopmental Disorders
- Pregnancy-related medical research
- Ectopic Pregnancy Diagnosis and Management
- Gestational Diabetes Research and Management
- Infant Nutrition and Health
- Neurogenetic and Muscular Disorders Research
- Pregnancy and Medication Impact
- Ovarian cancer diagnosis and treatment
- Metabolism and Genetic Disorders
- Genomics and Rare Diseases
- Chromatin Remodeling and Cancer
- Genetic Syndromes and Imprinting
- Gestational Trophoblastic Disease Studies
- Immune Response and Inflammation
- Genomic variations and chromosomal abnormalities
- RNA modifications and cancer
- Cardiovascular Issues in Pregnancy
Shanghai Jiao Tong University
2019-2025
International Peace Maternity & Child Health Hospital
2016-2025
Shanghai Municipal People's Government
2021
Bridge University
2020
Chelsea and Westminster Hospital
2011-2019
University Hospitals of Cleveland
2017
Hammersmith Hospital
2011
Imperial College London
2011
Both human preterm labor (PTL) and term are consistently associated with a chemokine-induced inflammatory infiltration of the myometrium. However, what regulates myometrial chemokine expression whether increase in precedes onset labor, so may have role its causation, or occurs after, is simply consequence uncertain. Therefore, we assessed 1) nonlaboring laboring samples obtained at before 2) factors that regulate expression. We found was characterized by an CXCL8 CCL2 both upper lower...
Abstract Background To determine the pathogenicity of a novel splicing variant in SMARCC2 gene identified from pair adult male monozygotic twins with neurodevelopmental disorder, and to investigate genotype-phenotype characteristics associated variants. Methods Whole-exome sequencing (WES) was conducted on proband, candidate variants were validated using Sanger within family. The effect mRNA processing analyzed reverse transcription PCR (RT-PCR) TA-clone samples derived proband. clinical...
The relationship between ozone (O3) exposure and gestational diabetes mellitus (GDM) in twin pregnancies remains unexplored. This study aimed to investigate the association O3 GDM risk pregnancies, explore synergistic effects of with other maternal factors. A total 428 recruited from a prospective cohort were included. Cox proportional hazard models distributed lag non-linear (DLNMs) applied examine associations identify critical windows. multiplicative additive interaction further analyzed...
Next-generation sequencing (NGS) has been applied for carrier screening, effectively reducing the incidence of severe diseases. However, some severe, high-prevalent and complex diseases, including spinal muscular atrophy (SMA), α-/β-thalassemia, 21-hydroxylase deficiency (21-OHD), fragile-X syndrome (FXS), cannot be fully addressed by NGS, resulting in a high residual risk ratio. This study aims to evaluate clinical utility long-read (LRS) panel screening these five A total 2926 participants...
The role of progesterone (P4) in the regulation local (uterine) and systemic innate immune system, myometrial expression connexin 43 (Cx-43) cyclooxygenase 2 (COX-2), onset parturition was examined (i) naïve mice delivering at term; (ii) E16 treated with RU486 (P4-antagonist) to induce preterm parturition; (iii) P4 prevent term parturition. In mice, neutrophil monocyte numbers peaked E18 declined contrast, circulating monocytes did not change although neutrophils were increased pregnancy,...
Inflammation plays a key role in human term and preterm labor (PTL). Intrauterine LPS has been widely used to model inflammation-induced complications of pregnancy, including PTL. It shown induce an intense myometrial inflammatory cell infiltration, but the LPS-induced activation onset fetal demise is unclear. We investigated this using mouse PTL, where intrauterine injection 10 μg (serotype 0111:B4) was given at E16 CD1 pregnancy. This dose induced PTL average 12.7 h postinjection...
Context:Progesterone administration reduces the risk of preterm labor in high-risk women with singleton pregnancies but has no effect a multiple pregnancy.
Population-wide carrier screening for spinal muscular atrophy (SMA) is recommended by professional organizations to facilitate informed reproductive options. However, genetic SMN1 2 + 0 carriers, accounting 3%-8% of all SMA has been challenging due the large gene size and long distance between SMN genes.Here we repurposed a previously developed long-read sequencing-based approach, termed comprehensive analysis (CASMA), identify carriers through haplotype in family trios (CASMA-trio)....
Problem Human labour is an inflammatory process with a heavy infiltration of immune cells into the myometrium and cervix induced by local chemokine production. Myometrial also express receptors, but there little information about their behaviour or function during pregnancy labour. Method Study We studied receptors ( CCR 2, CXCR 1 2) for CCL 2 CXCL 8 in human myometrium, because both have been shown to be important Results found that was significant decline m RNA expression all three upper...
For stable fallopian tube pregnancy (FTP), methotrexate (MTX) therapy is reported to be as effective laparoscopy. However, some cases would need further treatment, e.g., another dose of MTX or This study investigate the potential factors during treatment FTP that may facilitate prediction a successful outcome therapy.All admitted International Peace Maternal and Child Health Hospital (IPMCH), Shanghai, China from January 2016 December 2017 were reviewed. All patients received single 50 mg/m2...
Twin pregnancies have increased significantly over recent decades, mainly due to the growing rate of such that been achieved via assisted reproductive techniques. are associated with high infant morbidity and mortality. Maternal obesity has found be related an risk pre-eclampsia other adverse outcomes. weight gains during pregnancy may important implications for maternal fetus health. Women excessive gestational (GWG) more likely increase their diabetes mellitus (GDM), macrosomia, preterm...
Abstract Background Twin pregnancies are more likely to be affected by complications such as selective fetal growth restriction (sIUGR) which increase the risk of perinatal mortality and morbidity. Identifying those eiher sIUGR or birthweight discordant early can optimize counseling, timing interventions may, in future, allow trials preventative treatments. Objective The onset often correlates with increased levels cell-free DNA (cffDNA). Here we tested hypothesis that fraction (FF) twin...
Abstract In our earlier work, we found that intrauterine (i.u.) and intraperitoneal (i.p.) injection of LPS (10-μg serotype 0111:B4) induced preterm labor (PTL) with high pup mortality, marked systemic inflammatory response hypotension. Here, used both i.u. i.p. models in pregnant wild-type (wt) CCR2 knockout (CCR2−/−) mice on E16 to investigate the role played by CCL2/CCR2 system LPS. Basally, lower numbers monocytes macrophages higher neutrophils were myometrium, placenta, blood CCR2−/−...
Twin pregnancy constitutes significant risks for maternal and fetal health, which is usually detected by ultrasound examination at early gestation. However, the imaging-based approach may not accurately identify all twins confounded practical or clinical variables. The analysis of cell-free DNA in noninvasive prenatal screening assays can completement method twin detection, differentiates fraternal identical based on their distinct genotypes. Here, a new employing high-coverage...
Abstract Background Due to the extensive development of assisted reproductive technology, number twin pregnancies has increased significantly over recent decades. Twin pregnancy is most representative type multiple and associated with high infant morbidity mortality. Perinatal complications are also markedly compared those single pregnancy. Transabdominal selective reduction (SR) a remedial intervention. This study aimed research adverse outcomes transabdominal correlation between week...
Objective To test the hypothesis that fetal fraction in twin pregnancy would reflect birthweight discrepancy. Design Retrospective cohort study. Setting International Peace Maternity and Child Health Hospital Shanghai, China Population We included 237 pregnancies undergoing cfDNA screening for aneuploidy delivered at between January 2018 to December 2021. Exclusion criteria including abnormal NIPT results， demise or structural abnormalities. Methods All women with were offered a scan...