A5033183423- Ferroptosis and cancer prognosis
- Cancer-related molecular mechanisms research
- Metabolomics and Mass Spectrometry Studies
- Sepsis Diagnosis and Treatment
- Cancer Immunotherapy and Biomarkers
- Cancer, Lipids, and Metabolism
- Gallbladder and Bile Duct Disorders
- Pediatric Hepatobiliary Diseases and Treatments
- Renal function and acid-base balance
- Biliary and Gastrointestinal Fistulas
- RNA modifications and cancer
- MicroRNA in disease regulation
- Epigenetics and DNA Methylation
- Circular RNAs in diseases
- Colorectal Cancer Treatments and Studies
- Bacterial Identification and Susceptibility Testing
- Cancer, Hypoxia, and Metabolism
- Vitamin D Research Studies
- Cardiomyopathy and Myosin Studies
- Clusterin in disease pathology
- Environmental DNA in Biodiversity Studies
- Radiomics and Machine Learning in Medical Imaging
- High Entropy Alloys Studies
- Additive Manufacturing Materials and Processes
- Connective tissue disorders research
Shanghai CASB Biotechnology (China)
2024-2025
Northwest University
2021-2024
Johns Hopkins University
2024
Ministry of Education of the People's Republic of China
2021-2023
Baylor University
2023
BGI Group (China)
2013-2015
Science and Technology Department of Sichuan Province
2013
Objectives Sepsis is the major cause of death for critically ill patients. Recent progress in proteomics permits a thorough characterization mechanisms associated with critical illness. The purpose this study was to screen potential biomarkers early prognostic assessment patients sepsis. Methods For discovery stage, 30 sepsis different prognoses were selected. Urinary proteins identified using isobaric tags relative and absolute quantitation (iTRAQ) coupled LC-MS/MS. Mass spec instrument...
To identify metabolic biomarkers that can be used to differentiate sepsis from systemic inflammatory response syndrome (SIRS), assess severity and predict outcomes.65 patients were involved in this study, including 35 with sepsis, 15 SIRS normal patients. Small metabolites present patient serum samples measured by liquid chromatography mass spectrometry techniques analysed using multivariate statistical methods.The profiling of or was markedly different. A significant decrease the levels...
Colon cancer is one of the most common cancers, with 30–50 % patients returning or metastasizing within 5 years treatment. Increasingly, researchers have highlighted influence microbes on malignant activity, while no studies explored relationship between colon and in tumors. Here, we used tissue blood samples from 67 to identify pathogenic microorganisms associated diagnosis prediction evaluate predictive performance each marker its combination based next-generation sequencing data by using...
Background Colon adenocarcinoma (COAD) is characterized by high mortality and poor prognosis. Endoplasmic reticulum stress-related gene (ERSG) plays an indispensable role in the progression immunotherapy of COAD. In this study, we evaluated prognostic value ERSGs Methods We constructed validated ERSG-related signature based on public databases using univariate Cox analysis, Kaplan–Meier survival LASSO method, multivariate analysis. addition, TCGA-COAD, Human Protein Atlas, quantitative...
Background Cellular senescence (CS) is believed to be a major factor in the evolution of cancer. However, CS-related lncRNAs (CSRLs) involved colon cancer regulation are not fully understood. Our goal was create novel CSRLs prognostic model for predicting prognosis and immunotherapy exploring its potential molecular function Methods The mRNA sequencing data relevant clinical information GDC TCGA Colon Cancer (TCGA-COAD) were obtained from UCSC Xena platform, CS-associated genes acquired...
In Brief BACKGROUND Proteomics has only recently been applied to the field of critical care research. Sepsis is a major factor contributing intensive unit admissions and deaths. The purpose this study was screen potential urinary biomarkers for sepsis using A proteomics approach. METHODS Fifteen 15 systemic inflammatory response syndrome patients were involved in study. Urinary proteins identified by isobaric tag relative absolute quantitation coupled with liquid chromatography–tandem mass...
Background: Colon cancer is a common malignant tumor with poor prognosis. The aim of this study to explore the immune-related prognostic signatures and immune microenvironment colon cancer. Methods: mRNA expression data TCGA-COAD from UCSC Xena platform list genes (IRGs) ImmPort database were used identify differentially expressed (DEGs). Then, we constructed an risk score model validated its predictive performance in test dataset, whole two independent GEO datasets. In addition, explored...
The current study probed prognosis-related potential for m6A-related lncRNAs signatures within colon tumor immune microenvironment (TIM).After downloading transcriptomic datasets cancer (CC) patients from Cancer Genome Atlas (TCGA), they were divided, in a 1:1 ratio, training or test datasets. then scrutinized across such dataset using Pearson correlation assessment before generating model the dataset. latter was validated with and whole In addition, we compared differences of TIM estimated...
Abstract Background Biliary tract infection is a common complication of choledocholithiasis. This study aimed to analyse the distribution pathogenic bacteria in bile cultures from patients with choledocholithiasis combined biliary guide clinical application antimicrobials and reduce emergence drug resistance. Methods A total 880 were enrolled this retrospective 30 March 2017 31 August 2022 at Affiliated Hospital Qingdao University China. Bile specimens extracted for microbiological culture...
Objective Pseudomonas aeruginosa has strong drug resistance and can tolerate a variety of antibiotics, which is major problem in the management antibiotic-resistant infections. Direct prediction multi-drug (MDR) phenotypes P. isolates clinical samples by genotype helpful for timely antibiotic treatment. Methods In study, whole genome sequencing (WGS) data 494 were used to screen key anti-microbial (AMR)-associated genes related imipenem (IPM), meropenem (MEM), piperacillin/tazobactam (TZP),...
BackgroundCurrently, there are few studies on immune-related prognostic analysis of hepatocellular carcinoma (HCC). Our aim was to establish an immune-correlated model for HCC.MethodsImmune-associated cells were obtained from the scRNA-seq dataset (GSE149614) HCC. Differentially expressed genes between normal and tumor immune-associated ImmPort database used identify differentially (IRDEGs). Subsequently, risk established in TCGA-LIHC cohort (n = 438) Cancer Genome Atlas (TCGA) by using...
In this study, we compared the prognosis, tumor immune microenvironment (TIM), and drug treatment response between left-sided (LCC) right-sided (RCC) colon cancer to predict outcomes in patients with LCC RCC.Based on identified differentially expressed genes using single-cell RNA sequencing data, constructed validated a prognostic model for RCC TCGA-COAD cohort GSE103479 cohort. Moreover, differences of TIM characteristics patients.We five-gene four-gene patients, both showed excellent...
The present study focused on identifying the immune-related signatures and exploring their performance in predicting prognosis, immunotherapeutic responsiveness, diagnosis of patients with colon cancer. Firstly, response-related differential expressed genes (DEGs) were identified by comparing responders non-responders from an anti-PD-L1 cohort using edgeR R package. Then, response related DEGs was intersected (IRGs) to obtain (IRIGs). risk score (IRIRScore) model consisting 6 IRIGs...
Kaempferol has demonstrated notable positive effects on the osteogenic differentiation of mesenchymal stem cells (MSC) and osteoblasts. A substantial body research emphasized role dislodged titanium particles in aseptic loosening following joint replacement surgery. This study predominantly investigates suppressive influence osteolysis induced by (Ti) alloy particles. In vitro investigations disclosed that effectively enhanced mineralization alkaline phosphatase (ALP) activity bone-marrow...
The intratumoral microorganisms participates in the progression and immunotherapy of colorectal cancer (CRC). However, due to technical limitations, impact on CRC has not been fully understood. Therefore, we conducted a systematic analysis relationship between bacterial lipopolysaccharide (LPS)-associated genes immune cells explore new biomarkers for predicting prognosis CRC.
The effectiveness of endoscopic papillary large balloon dilation (EPLBD) alone versus EPLBD combined with sphincterotomy (EST) in treating common bile duct stones (CBDS, ≥ 15 mm) remains unclear. This study aimed to evaluate the safety and treatment outcomes limited or EST removing CBDS. Between January 2013 September 2024, 408 patients underwent EPLBD, either combination EST, treat CBDS (≥ mm). were divided into three groups: (n = 92), 124), 192). compared first-session stone clearance...
Obstructive sleep apnea (OSA) is a common syndrome characterized by upper airway dysfunction during sleep. Continuous positive pressure (CPAP) the most frequently utilized non-surgical treatment for OSA. Ferroptosis play crucial role in physiological diseases caused chronic intermittent hypoxia, but its involvement development of OSA and exact mechanisms have incompletely elucidated. GSE75097 microarray dataset was used to identify differentially expressed genes between patients CPAP-treated...
Abstract The present study aimed to construct a novel methylation‐related prognostic model based on microsatellite status that may enhance the prognosis of colorectal cancer (CRC) from methylation and perspective. DNA mRNA expression data with clinical information were downloaded Cancer Genome Atlas (TCGA) set. samples divided into stability instability group, CIBERSORT was used assess immune cell infiltration characteristics. After identifying differentially methylated genes using R...