A5101610200- Hematopoietic Stem Cell Transplantation
- Chemokine receptors and signaling
- Acute Myeloid Leukemia Research
- Effects of Radiation Exposure
- Immune cells in cancer
- Immunotherapy and Immune Responses
- Cytokine Signaling Pathways and Interactions
- Cancer, Stress, Anesthesia, and Immune Response
- Mesenchymal stem cell research
- Neonatal Respiratory Health Research
- Cancer, Hypoxia, and Metabolism
- Immune Response and Inflammation
- T-cell and B-cell Immunology
- Hematological disorders and diagnostics
- Chronic Myeloid Leukemia Treatments
- Chronic Lymphocytic Leukemia Research
- MicroRNA in disease regulation
- Cell death mechanisms and regulation
- Histone Deacetylase Inhibitors Research
- Phagocytosis and Immune Regulation
- RNA Interference and Gene Delivery
- Nanoparticle-Based Drug Delivery
- Glycosylation and Glycoproteins Research
- Liver physiology and pathology
- Lung Cancer Research Studies
Indiana University School of Medicine
2016-2025
Indiana University – Purdue University Indianapolis
2015-2025
Patanjali Research Foundation
2024
Shobhit University
2024
Krishi Vigyan Kendra, Ghatkhed Amravati
2023
StemCells (United States)
2020
Narendra Dev University of Agriculture and Technology
2020
Indiana University
2014-2019
University School
2014
Dabur Research Foundation (India)
2012-2014
The bone marrow (BM) microenvironment/niche plays a key role in regulating hematopoietic stem and progenitor cell (HSPC) activities; however, mechanisms niche function are not well understood. In this study, we show that intrinsic expression of the CXCR4 chemokine receptor critically regulates HSPC maintenance during steady state, promotes early regeneration after myeloablative irradiation. At chimeric mice with wild-type (WT) stroma lack decreased quiescence, their repopulation capacity was...
Abstract Successful proliferation and differentiation of hematopoietic progenitor cells in bone marrow (BM) is essential to generate all mature blood cell types, including those involved the immune response. Although vaccinia virus (VV) known induce a strong response, effect VV infection on hematopoiesis remains largely unknown. Here, we showed that vivo results expansion c-KithiSca-1+Lin− (KSL) stem cells. The KSL population requires MyD88 critical adaptor for Toll-like receptor-mediated...
Endothelial cells (ECs) are components of the hematopoietic microenvironment and regulate stem progenitor cell (HSPC) homeostasis. Cytokine treatments that cause HSPC trafficking to peripheral blood associated with an increase in dipeptidylpeptidase 4/CD26 (DPP4/CD26), enzyme truncates neurotransmitter neuropeptide Y (NPY). Here, we show enzymatically altered NPY signaling ECs caused reduced VE-cadherin CD31 expression along EC junctions, resulting increased vascular permeability egress....
A cross-sectional study was conducted for assessing the entrepreneurial aptitude of women in two blocks (Kashipur and Gadarpur) Udham Singh Nagar, Uttarakhand. purposive sampling technique utilized selecting respondents. structured questionnaire vetted by experts pretested through a pilot on 45 respondents developed. Data entrepreneurs, self-assessment, perception farm regarding collected from 214 during month June 2022 to August 2022. Results revealed that only 28.50 per cent were running...
16, 16 dimethyl-Prostaglandin E2 (dmPGE2) administered prior to lethal irradiation protects against mortality from the hematopoietic acute radiation syndrome (H-ARS). It stem (HSC) and progenitor (HPC) cells accelerates recovery by attenuating mitochondrial compromise, epigenetic downregulation of p53, inhibition histone acetylation at promoters genes involved in cell cycle, DNA repair apoptosis. Since PGE2 mediates it effects through 4 conserved G-protein coupled receptors (EP1-4) we...
Ionizing radiation exposure results in acute and delayed bone marrow suppression. Treatment of mice with 16,16-dimethyl prostaglandin E2 (dmPGE2) prior to lethal ionizing (IR) facilitates survival, but the cellular molecular mechanisms are unclear. In this study we show that dmPGE2 attenuates loss enhances recovery cellularity, corresponding a less severe hematopoietic stem cell nadir, significantly preserves long-term repopulation capacity progenitor function. Mechanistically, suppressed...
Abstract Objectives: The aim of this study was to evaluate the effects prostaglandin E 2 (PGE ) on haematopoietic stem cell (HSC) function and determine its mechanism action. Materials methods: HSC were exposed PGE for h their homing, engraftment self‐renewal evaluated in vivo . Effects cycle, CXCR4 expression migration SDF‐1α analysed vitro Apoptosis by examination survivin active caspase‐3 levels. Results: Equivalent reconstitution demonstrated using 4‐fold fewer ‐treated cells compared...
Although mesenchymal stromal cells (MSCs) have significant potential in cell-based therapies, little is known about the factors that regulate their functions. While exploring regulatory molecules potentially involved MSC activities, we found endogenous multifunctional factor Survivin essential for survival, expansion, lineage commitment, and migration. Pharmacological or genetic blockade of expression mouse human bone marrow enhances caspase 3 7 reduces proliferation resulting fewer...
Internal tandem duplication (ITD) mutations in the Fms-related tyrosine kinase 3 (FLT3) gene (FLT3-ITD) are associated with poor prognosis patients acute myeloid leukemia (AML). Due to development of drug resistance, few FLT3-ITD inhibitors effective against FLT3-ITD+ AML. In this study, we show that activates a novel pathway involving p21Cdkn1a (p21) and pre-B cell transcription factor 1 (Pbx1) attenuates proliferation is involved resistance. up-regulated p21 expression both mouse bone...
Identification of medical countermeasures (MCM) to mitigate radiation damage and/or protect first responders is a compelling unmet need. The prostaglandin E2 (PGE2) analog, 16,16 dimethyl-PGE2 (dmPGE2), has shown efficacy as radioprotectant and radiomitigator that can enhance hematopoiesis ameliorate intestinal mucosal cell damage. In this study, we optimized the time administration dmPGE2 for protection mitigation against mortality from hematopoietic acute syndrome (H-ARS) in young adult...