A5070791591- Porphyrin and Phthalocyanine Chemistry
- Photodynamic Therapy Research Studies
- Nanoplatforms for cancer theranostics
- Porphyrin Metabolism and Disorders
- Heme Oxygenase-1 and Carbon Monoxide
- Human-Automation Interaction and Safety
- Older Adults Driving Studies
- Fluorine in Organic Chemistry
- Transportation and Mobility Innovations
University of Coimbra
2008-2015
This paper describes an environmentally sustainable synthetic method for the preparation of a set meso-aryl hydroporphyrins, namely chlorins and bacteriochlorins, via reduction porphyrins with diimide, in total absence solvents bases. Thermomicroscopy studies clearly showed that process is typical solvent-free reaction.
Photodynamic therapy (PDT) is a promising treatment for several types of cancers. It involves the synergetic effect light, oxygen and an appropriate photosensitizer. Extensive studies on synthetic modulation structure tetrapyrrolic macrocycles allowed optimization chemical physical properties such photosensitizers. The progress from porphyrins to chlorins more recently bacteriochlorins clearly shows improvements achieved in PDT This paper summarizes our recent contribution synthesis stable...
Synthesis, labeling and initial biodistribution studies of a new [<sup>18</sup>F] radiolabeled <italic>meso</italic>-tetraphenylporphyrin (radiochemical purity >95%). Includes human bladder tumor cell uptake data.
Ideal reaction conditions were found to promote the "cold" monomethylation of 5,10,15,20-tetrakis(3-hydroxyphenyl)porphyrin with CH 3 I , at minute time scale, in presence base. The photophysical characterization, cellular uptake and dark cytotoxicity resulting monomethylated porphyrin appraised. Moreover, syntheses corresponding labeled porphyrin, using short-lived carbon-11, prepared automated radiolabeling system efficiently performed. purification product was achieved via preparative...
Abstract The preparation of meso‐aryl hydroporphyrins, namely chlorins (II) and bacteriochlorins (IV), proceeds via reduction porphyrins (I) (III) with diimide in the absence solvents bases.