A5024000706- Porphyrin and Phthalocyanine Chemistry
- Photodynamic Therapy Research Studies
- Nanoplatforms for cancer theranostics
- Luminescence and Fluorescent Materials
- Lanthanide and Transition Metal Complexes
- Molecular Sensors and Ion Detection
- Synthesis and Characterization of Pyrroles
- Radiopharmaceutical Chemistry and Applications
- Click Chemistry and Applications
- Porphyrin Metabolism and Disorders
- Extracellular vesicles in disease
- Health Education and Validation
- DNA Repair Mechanisms
- Nursing Diagnosis and Documentation
- Radiation Therapy and Dosimetry
- Heme Oxygenase-1 and Carbon Monoxide
- Molecular Junctions and Nanostructures
- Electron Spin Resonance Studies
- Surface Chemistry and Catalysis
- Sentiment Analysis and Opinion Mining
- Multicomponent Synthesis of Heterocycles
- Amyloidosis: Diagnosis, Treatment, Outcomes
- Cardiac Arrhythmias and Treatments
- Patient Safety and Medication Errors
- Synthesis and Properties of Aromatic Compounds
University of Coimbra
2015-2025
Universidade do Porto
2023
Cambridge Quantum Computing (United Kingdom)
2016
Hospital de Santa Maria
2015
Universidad de Burgos
2009
Universitat de Miguel Hernández d'Elx
2009
Diamagnetic metal complexes of phthalocyanines with n-butoxyl groups in all the α-benzo positions macrocycle skeleton, MPc(OBu)8, have strong near-infrared absorptions and intense fluorescences that are Stokes shifted by more than 15 nm. Interestingly, silicon complex 6 is also remarkably photostable nontoxic. The use fluorescence imaging BALB/c mice bearing a 4T1-luc2 tumor mammary fat pad unambiguously revealed presence when it was only 1 mm diameter not visible naked eye. Compound has an...
A class of amphiphilic photosensitizers for photodynamic therapy (PDT) was developed. Sulfonate esters modified porphyrins bearing—F substituents in the ortho positions phenyl rings have adequate properties PDT, including absorption red, increased cellular uptake, favorable intracellular localization, low cytotoxicity, and high phototoxicity against A549 (human lung adenocarcinoma) CT26 (murine colon carcinoma) cells. Moreover, role type I II photochemical processes assessed by fluorescent...
Although complexes of the paramagnetic Gd(III) ion have been used with great success for past 40 years to enhance image contrast in magnetic resonance imaging (MRI), important challenges such as improving relaxation efficacy, specificity, safety, and environmental impact these agents remain this field. Thanks a collaborative effort between Centre Molecular Biophysics Orléans, France Coimbra Chemistry - Institute Sciences Coimbra, Portugal, there advances chemistry MRI probes. The authors...
This study introduces a novel approach for the one‐step preparation of carboxamide porphyrin‐amino acid bioconjugates via palladium/xantphos‐catalyzed aminocarbonylation 5,15‐dibromo‐10,20‐diphenylporphyrin and 5,10,15,20‐tetrakis(4‐bromophenyl)porphyrin, under relatively mild conditions (70‐100 ºC, 1 atm CO), using natural amino methyl ester derivatives as N‐nucleophiles. optimized methodology led to different families amphiphilic porphyrins containing between one four acids through bonds,...
Abstract Water, under microwave irradiation and at a temperature of 473 K, reaches pressures above 16 bar, being capable to act as catalyst, without the use organic solvents oxidants, for meso ‐substituted porphyrin synthesis. Sustainability reaction is proved by E Factor=35 EcoScale value 50.5, highest so far obtained Methodology’s wide versatility clearly demonstrated good yields both aryl alkyl substituted porphyrins. These conditions represent huge development, not only using very high...
The field of imaging science is growing immensely, with the emergence "noninvasive" in vivo technologies and probes like Positron Emission Tomography (PET), Fluorescence Imaging (FI) Magnetic Resonance (MRI), to observe events at molecular cellular levels, consequently speed up drug development processes. For instance, cancer specific targets ought permit precocious diagnosis superior evaluation oncology patients. Porphyrins their derivatives (or related compounds, phthalocyanines) represent...
The easy access and low price of pyrrole aldehydes, conjugated with the simplicity in preparing meso-substituted porphyrins, makes this type porphyrins very attractive for a broad range applications. However, there is an increasing demand development new synthetic processes involving more sustainable chemical principles substituting, whenever possible, dangerous organic solvents by alternative solvents, chromatographic purifications precipitations energy-intensive procedures energy sources...
Nowadays, society’s widespread consumption of pharmaceutical drugs and the consequent accumulation such compounds or their metabolites in effluents requires development efficient strategies systems that lead to effective degradation. This can be done through oxidative processes, which tetrapyrrolic macrocycles (porphyrins, phthalocyanines) deserve special attention since they are among most promising degradation catalysts. paper presents a review literature over past ten years on major...
Photodynamic therapy (PDT) is a promising treatment for several types of cancers. It involves the synergetic effect light, oxygen and an appropriate photosensitizer. Extensive studies on synthetic modulation structure tetrapyrrolic macrocycles allowed optimization chemical physical properties such photosensitizers. The progress from porphyrins to chlorins more recently bacteriochlorins clearly shows improvements achieved in PDT This paper summarizes our recent contribution synthesis stable...
ADVERTISEMENT RETURN TO ISSUEPREVCommunicationNEXTSynthesis of New Metalloporphyrin Triads: Efficient and Versatile Tripod Optical Sensor for the Detection AminesSara M. A. Pinto, Mirtha O. Lourenço, Mário J. F. Calvete, Artur R. Abreu, T. S. Rosado, Hugh D. Burrows*, Mariette Pereira*View Author Information Departamento de Química, Universidade Coimbra, PortugalE-mail: [email protected] (M.M.P.), (H.D.B.). Tel: +351239854474. Fax: +351239827703.Cite this: Inorg. Chem. 2011, 50, 17,...
A water-soluble fluorinated Mn<sup>III/II</sup> porphyrin responds reversibly to ascorbate redox state as a turn-on MRI probe.
Abstract A new water soluble fluorene‐based polyelectrolyte containing on‐chain porphyrin units has been synthesized via Suzuki coupling, for use in optoelectronic devices. The material consist of a random copolymer poly{1,4‐phenylene‐[9,9‐bis(4‐phenoxy butylsulfonate)]fluorene‐2,7‐diyl} (PBS‐PFP) and 5,15‐diphenylporphyrin (DPP). energy transfer process between the PBS‐PFP investigated through steady state time‐resolved measurements. PBS‐PFP‐DPP displays two different emissions one located...
Synthesis, labeling and initial biodistribution studies of a new [<sup>18</sup>F] radiolabeled <italic>meso</italic>-tetraphenylporphyrin (radiochemical purity >95%). Includes human bladder tumor cell uptake data.
A new fluorinated manganese porphyrin, (Mn-TPP-p-CF3 ) is reported capable of providing, based on the Mn(III)/Mn(II) equilibrium, dual 1 H relaxivity and 19 F NMR response to redox changes. The physical-chemical characterization both states in DMSO-d6 /H2 O evidenced that relaxometric properties are appropriate for differential MRI detection. Mn(III)-F distance (dMn-F =9.7-10 Å), as assessed by DFT calculations, well tailored allow adequate paramagnetic effect Mn(III) T1 T2 relaxation times....
A new ecofriendly methodology for low melting<italic>meso</italic>-substituted metalloporphyrin synthesis is described. This displays one of the best sustainability classifications involving porphyrin synthesis.
Herein we report the synthesis of unsymmetrical meso-aryl substituted porphyrins, using NaY zeolite as an inorganic acid catalyst. A comparative study between this method and several synthetic strategies available in literature was carried out. Our presented a better, more cost-efficient rationale displayed significantly lower environmental impact. Furthermore, it possible to verify scalability process well reutilization catalyst (up 6 times) without significant yield decrease. In addition,...