A5031099018- Neonatal Respiratory Health Research
- Neuroscience of respiration and sleep
- Respiratory Support and Mechanisms
- Congenital Diaphragmatic Hernia Studies
- Neonatal and fetal brain pathology
- Asthma and respiratory diseases
- Receptor Mechanisms and Signaling
- Lung Cancer Treatments and Mutations
- Birth, Development, and Health
- Neonatal and Maternal Infections
- Thermal Regulation in Medicine
- Sepsis Diagnosis and Treatment
- Infrared Thermography in Medicine
- Pulmonary Hypertension Research and Treatments
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Sulfur Compounds in Biology
- Mesenchymal stem cell research
- Neonatal Health and Biochemistry
- Infant Development and Preterm Care
- Cardiovascular Conditions and Treatments
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Cardiac Arrest and Resuscitation
- Nicotinic Acetylcholine Receptors Study
- Nitric Oxide and Endothelin Effects
- Asymmetric Synthesis and Catalysis
Case Western Reserve University
2015-2024
Rainbow Babies & Children's Hospital
2014-2024
University School
2017-2022
Pediatrics and Genetics
2021
University Hospitals of Cleveland
2021
Nationwide Children's Hospital
2013
The Ohio State University
2013
Boston Children's Hospital
2012
<b><i>Introduction:</i></b> Length of hospitalization varies widely in preterm infants and can be affected by multiple maternal neonatal factors including respiratory instability. Therefore, we aimed to determine the association between postnatal intermittent hypoxemia (IH) prolonged hospitalization. <b><i>Methods:</i></b> This prospective single-center cohort study followed born at &lt;31 weeks gestational age through 2 years corrected...
Bronchopulmonary dysplasia (BPD) is characterized by lifelong obstructive lung disease and profound, refractory bronchospasm. It observed among survivors of premature birth who have been treated with prolonged supplemental oxygen. Therapeutic options are limited. Using a neonatal mouse model BPD, we show that hyperoxia increases activity expression mediator endogenous bronchoconstriction, S-nitrosoglutathione (GSNO) reductase. MicroRNA-342-3p, predicted in silico shown this study vitro to...
<b><i>Background:</i></b> Continuous positive airway pressure (CPAP) and supplemental oxygen have become the mainstay of neonatal respiratory support in preterm infants. Although therapy is associated with morbidities including bronchopulmonary dysplasia (BPD), long-term effects CPAP on lung function are largely unknown. We used a hyperoxia-induced mouse model BPD to explore daily first week life later system mechanics. <b><i>Objective:</i></b>...
Abstract Idiopathic pulmonary fibrosis (IPF) is a progressive disease characterized by interstitial remodeling and dysfunction. The etiology of IPF not completely understood but involves pathologic inflammation subsequent failure to resolve in response epithelial injury. Treatments for are limited anti-inflammatory immunomodulatory agents, which only partially effective. Prostaglandin E2 (PGE2) disrupts TGFβ signaling suppresses myofibroblast differentiation, however practical strategies...
Intermittent hypoxaemia (IH) events are well described in extremely preterm infants, but the occurrence of IH patterns more mature infants remains unclear. The objective this study was to characterise effect gestational age on early postnatal (<28 weeks), very (28–<32 weeks) and moderately (32–<34 infants. As expected, had a significantly higher frequency longer durations greater time with versus In addition, decrease duration comparable This progression should assist clinicians...
<b><i>Background:</i></b> Preterm infants with neonatal lung injury are prone to wheezing and often treated β<sub>2</sub>-adrenergic receptor (β-AR) agonists although the benefits of β-AR may be lost chronic use. <b><i>Objective:</i></b> To investigate if repeated agonist exposure downregulates β-ARs in immature resulting a decreased response bronchodilator rescue whether hyperoxic aggravates this response....
Altered functions of the lung epithelial surface likely contribute to respiratory morbidities in infants with bronchopulmonary dysplasia (BPD). Infants BPD exhibit decreased expressions secretoglobins (SCGBs), including Clara cell secretory protein (CCSP). Expression SCGB and annexin A1 (ANXA1) is persistently altered CCSP knockout mice suggesting that indirectly influences innate immune responses. The present studies tested hypothesis neonatal hyperoxic exposure induces deficits expression...
<b><i>Introduction:</i></b> Lipid peroxidation products are present following oxidation of polyunsaturated fatty acids in the eye, brain, and various cell membranes. Elevated levels lipid increased intermittent hypoxemia (IH) events have been associated with adverse outcomes extremely preterm infants. The moderate newborn has a still-developing oxidant defense system immature respiratory control, but little is known about IH this larger more common population....
Preterm infants with respiratory distress may require mechanical ventilation which is associated increased pulmonary morbidities. Prompt and successful extubation to noninvasive support a pressing goal. In this communication, we show original data that recurring intermittent hypoxemia (IH, oxygen saturation <80%) be failure at 72 h in cohort of neonates <30 weeks gestational age. Current-generation bedside high-resolution pulse oximeters provide profiles use identifying readiness...
-nitrosothiols (SNOs) are endogenous signaling molecules that have numerous beneficial effects on the airway via cyclic guanosine monophosphate-dependent and -independent processes. Healthy human airways contain SNOs, but SNO levels lower in of patients with cystic fibrosis (CF). In this study, we examined interaction between SNOs molecular cochaperone C-terminus Hsc70 interacting protein (CHIP), which is an E3 ubiquitin ligase targets improperly folded CF transmembrane conductance regulator...