A5079776530- Neonatal Respiratory Health Research
- Respiratory Support and Mechanisms
- Congenital Diaphragmatic Hernia Studies
- Neuroscience of respiration and sleep
- Gut microbiota and health
- Asthma and respiratory diseases
- Infant Nutrition and Health
- Pediatric health and respiratory diseases
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- COVID-19 Impact on Reproduction
- Inhalation and Respiratory Drug Delivery
- Pediatric Pain Management Techniques
- Bacterial Infections and Vaccines
- Vaccine Coverage and Hesitancy
- Epigenetics and DNA Methylation
- Infant Development and Preterm Care
- Melanoma and MAPK Pathways
- Neurogenetic and Muscular Disorders Research
- Neonatal and Maternal Infections
- Cell Adhesion Molecules Research
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Child and Adolescent Health
- Retinopathy of Prematurity Studies
- Monoclonal and Polyclonal Antibodies Research
- Diabetes and associated disorders
University of Rochester Medical Center
2019-2025
University of Rochester
2018-2024
Golisano Children's Hospital
2018-2021
Rainbow Babies & Children's Hospital
2015-2017
Case Western Reserve University
2016-2017
Stony Brook University
2010
State University of New York
2008
Bronchopulmonary dysplasia (BPD) is a neonatal lung disease characterized by inflammation and scarring leading to long-term tissue damage. Previous whole proteomics identified BPD-specific proteome changes cell type shifts. Little known about the proteome-level within specific populations in disease. Here, we sorted epithelial (EPI) endothelial (ENDO) based on their differential surface markers from normal BPD human lungs. Using low-input compatible sample preparation method (MicroPOT),...
OBJECTIVE. Tetanus, diphtheria, and acellular pertussis vaccination is recommended for adults who are in contact with infants younger than 12 months the NICU. The objective of this study was to determine feasibility tetanus, vaccine administration parents a tertiary care, level III NICU measure its effect on rates among high-risk population. METHODS. For 4-month period from July October 2007, all admitted patients were informed risks benefits by placing an information letter at their...
Bronchopulmonary dysplasia (BPD) is a disease of prematurity related to the arrest normal lung development. The objective this study was better understand how proteome modulation and cell-type shifts are noted in BPD pathology. Pediatric human donors aged 1-3 yr were classified based on history histopathology consistent with "healed" (hBPD, n = 3) "established" (eBPD, compared respective full-term born (n 6) age-matched term controls. Proteins quantified by tandem mass spectroscopy selected...
Abstract Very low birth weight (VLBW) infants, even those without bronchopulmonary dysplasia (BPD) are at risk for pulmonary morbidity during infancy. Although some studies have found an association between the level of neonatal oxygen exposure and later morbidity, others not. A possible explanation these inconsistent findings is that cumulative dosage supplemental to which infants difficult accurately quantify. Methods: prospective cohort study VLBW BPD was performed test hypothesis in...
Neonatal immune-microbiota co-development is poorly understood, yet age-appropriate recognition of – and response to pathogens commensal microbiota critical health. In this longitudinal study 148 preterm 119 full-term infants from birth through one year age, we found that postmenstrual age or weeks conception a central factor influencing T cell mucosal development. Numerous features the functional development remain unexplained; however, by either metric are instead shaped discrete perinatal...
Bronchopulmonary dysplasia (BPD) is characterized by lifelong obstructive lung disease and profound, refractory bronchospasm. It observed among survivors of premature birth who have been treated with prolonged supplemental oxygen. Therapeutic options are limited. Using a neonatal mouse model BPD, we show that hyperoxia increases activity expression mediator endogenous bronchoconstriction, S-nitrosoglutathione (GSNO) reductase. MicroRNA-342-3p, predicted in silico shown this study vitro to...
The severity of COVID-19 lung disease is higher in the elderly and people with pre-existing co-morbidities. People who were born preterm may be at greater risk for because their early exposure to oxygen (hyperoxia) birth increases respiratory viral infections. Hyperoxia influenza A virus infections adult mice by reducing number alveolar epithelial type 2 (AT2) cells. Since AT2 cells express SARS-CoV-2 receptors angiotensin converting enzyme (ACE2) transmembrane protease/serine subfamily...
Pulmonary fibrosis is an interstitial scarring disease of the lung characterized by poor prognosis and limited treatment options. Tissue transglutaminase 2 (TG2) believed to promote crosslinking extracellular matrix components activating latent TGFβ. This study assessed physiologic pulmonary function metabolic alterations in mouse bleomycin model with TG2 genetic deletion. TG2-deficient mice demonstrated attenuated preservation function, significant reduction elastance increases compliance...
Failed extubations are associated with pulmonary morbidity in hospitalized premature newborns. The objective of this study was to use quality improvement methodology reduce failed through practice standardization and integrating a real-time extubation success calculator into the electronic medical record (EMR).
Background: Prevention of chronic lung disease (CLD) requires a multidisciplinary approach spanning from the delivery room to Neonatal Intensive Care Unit (NICU) discharge. In 2018, quality improvement (QI) initiative commenced in level 4 NICU with goal decreasing rates below Vermont Oxford Network (VON) average 24%. Methods: Improvement strategies focused on addressing primary drivers ventilation strategies, surfactant administration, non-invasive ventilation, medication use, and...
Identifying neonatal and post-discharge exposures among extremely low gestational age newborns (ELGANs) that drive increased pulmonary morbidity abnormal lung function at 1 year of proves challenging.The NIH-sponsored Prematurity Respiratory Outcomes Program (PROP), evaluated infant tests (iPFTs) corrected to determine which demographic clinical factors are associated with function.iPFTs were performed on a PROP subcohort 135 participants following Institutional Review Board (IRB)-approved...
ABSTRACT The severity of COVID-19 lung disease is higher in the elderly and people with pre-existing co-morbidities. People who were born preterm may be at greater risk for because their early exposure to oxygen birth increases being hospitalized when infected RSV other respiratory viruses. Our prior studies mice showed how high levels (hyperoxia) between postnatal days 0-4 influenza A virus infections by reducing number alveolar epithelial type 2 (AT2) cells. Because AT2 cells express...
Respiratory syncytial virus (RSV) is a dominating respiratory infection worldwide. It responsible for infecting millions of children worldwide each winter through highly contagious droplets and secretions. Over 2.1 million these require some form medical attention during illness. Due to this high disease burden, the development new agents prevent or reduce spread RSV has been top priority. Recently, nirsevimab, monoclonal antibody was introduced 2023-2024 season that holds promise limiting...
Abstract Neonatal immune-microbiota co-development is poorly understood, yet appropriate recognition of – and response to pathogens commensal microbiota critical health. In this longitudinal study 148 pre- 119 full-term infants from birth through one year age we found that postmenstrual age, or weeks conception, not post-natal the dominant factor influencing T cell mucosal development. Numerous features functional development remain unexplained, however, by either metric are instead shaped...
It is well known that supplemental oxygen used to treat preterm infants in respiratory distress associated with permanently disrupting lung development and the host response influenza A virus (IAV). However, many who go home normally functioning lungs are also at risk for hyperreactivity after a viral infection. We recently reported new, low-dose hyperoxia mouse model (40% 8 days; 40×8) causes transient change function resolves, rendering 40×8 adult animals functionally indistinguishable...
Children and young adults with mutant forms of ataxia telangiectasia mutated (ATM), a kinase involved in DNA damage signaling mitochondrial homeostasis, suffer from recurrent respiratory infections, immune deficiencies, obstructive airways disease associated disorganized airway epithelium. We previously showed mice how Atm was required to mount protective memory response influenza A virus [IAV; Hong Kong/X31 (HKx31), H3N2]. Here, wildtype (WT) knockout (Atm-null) were used investigate is...