A5016067328- Multiple Myeloma Research and Treatments
- Chronic Lymphocytic Leukemia Research
- Lung Cancer Research Studies
- Acute Myeloid Leukemia Research
- Lung Cancer Treatments and Mutations
- Cancer Immunotherapy and Biomarkers
- Protein Kinase Regulation and GTPase Signaling
- Cancer, Lipids, and Metabolism
- Drug-Induced Adverse Reactions
- Cancer Genomics and Diagnostics
- Chemotherapy-related skin toxicity
- Cancer Treatment and Pharmacology
- Lymphoma Diagnosis and Treatment
- Inflammatory Biomarkers in Disease Prognosis
- Lung Cancer Diagnosis and Treatment
- Ferroptosis and cancer prognosis
- Protein Structure and Dynamics
- Cellular transport and secretion
- Cell death mechanisms and regulation
- Face recognition and analysis
- Hematopoietic Stem Cell Transplantation
- Monoclonal and Polyclonal Antibodies Research
- Neutropenia and Cancer Infections
- Bladder and Urothelial Cancer Treatments
- Cardiac tumors and thrombi
Case Western Reserve University
2015-2024
Biostats (United States)
2019-2022
University School
2012-2021
Case Comprehensive Cancer Center
2021
University Hospitals of Cleveland
2021
University Hospitals Seidman Cancer Center
2020-2021
Nanjing Drum Tower Hospital
2014
Wuhan Institute of Physics and Mathematics
2014
Chinese Academy of Sciences
2014
Central China Normal University
2009-2012
Ras genes potently drive human cancers, with mutated proto-oncogene GTPase KRAS4B (K-Ras4B) being the most abundant isoform. Targeted inhibition of oncogenic gene products is considered "holy grail" present-day cancer therapy, and recent discoveries small-molecule KRas4B inhibitors were made thanks to a deeper understanding structure dynamics this GTPase. Because interactions biological membranes are key for function, Ras-lipid have become major focus, especially because such evidently...
<h3>Background:</h3> Fecal immunochemical testing (FIT) and multi-target stool DNA (mt-sDNA) are recommended colorectal cancer screening options but require follow-up with colonoscopy to determine the source of a positive result. We performed retrospective analysis in an academic health system adherence these patients. <h3>Methods:</h3> identified all patients aged 40 years older at least 1 primary care visit who had FIT or mt-sDNA between January 2016 June 2018. receipt within 6 months test...
Outcome of Multiple Myeloma (MM) patients has improved as the result introduction novel medications and use autologous hematopoietic cell transplantation. However, this improvement comes at expense increased financial burden. It is largely unknown if socioeconomic factors influence MM survival.We used National Cancer Database, a database that houses data on 70% cancer in US, to evaluate effect survival 117,926 diagnosed between 2005 2014.Patients aged ≥65 years who were privately insured...
In-cell NMR spectroscopy provides insight into protein conformation, dynamics, and function at atomic resolution in living cells. Systematic evaluation of isotopic-labeling strategies is necessary to observe the target sea other molecules cell. Here, we investigate detectability, sensitivity, in-cell spectra globular proteins GB1, ubiquitin, calmodulin, bcl-xl-cutloop, resulting from uniform (15)N enrichment (with without deuteration), selective (15)N-Leu enrichment, (13)C-methyl isoleucine,...
Azacitidine (AZA) maintenance following allogeneic hematopoietic cell transplantation (HCT) for acute myeloid leukemia (AML) and myelodysplastic syndrome (MDS) may reduce relapse risk improve survival. Given logistic toxicity-related challenges, identifying subgroups appropriate this approach is an unmet need. Using data from two centers, we retrospectively compared event-free survival (EFS) overall (OS) of AML MDS patients who received AZA (n = 59) with historic controls 90). Controls were...
Human papillomavirus-associated head and neck squamous cell carcinoma (HPV+ HNSCC) is recognized as a distinct disease with unique etiology clinical features. Current standard of care therapeutic modalities are identical for HPV+ HPV- HNSCC thus, there remains an opportunity to develop innovative pharmacologic approaches exploit the inherent vulnerabilities HNSCC. In this study, using inducible HPVE6E7 knockdown system, we found that cells addicted HPVE6E7, such loss these viral oncogenes...
Patients with certain autoimmune conditions are at a reduced risk of developing breast cancer compared to the general population. Despite this, little is known about outcomes in patients who have concurrent diagnosis.This study differences between women had or did not an diagnosis. The SEER-Medicare databases (2007-2014) were used identify and diagnosis codes those disorder.The studied diseases prevalence 27% among 137,324 cancer. Autoimmune disease was associated significantly longer...
Patients enrolled in Phase 1 clinical trials have typically exhausted standard therapies and often are choosing between a trial hospice care. Significant symptom burden can result early discontinuation confound outcomes. This study aimed to examine differences duration, burden, adverse events (AE), quality of life (QOL) those receiving structured palliative care versus usual supportive care.Sixty-eight patients phase 39 their CGs were randomly assigned receive or Patient QOL was measured...
Venous thromboembolic events (VTE) are a frequent complication of lymphoma. We conducted retrospective analysis to compare VTE risk in diffuse large B-cell lymphoma (DLBCL) and follicular (FL). Subjects were randomly assigned training validation sets identify factors evaluate model performance, including the Khorana score. A group 790 patients diagnosed from 2002 2014 (DLBCL = 542, FL 248). Median follow- up was 49 months. observed 106 VTE, with higher incidence DLBCL (5-year cumulative...
Few small sample size studies have reported lymphocyte count was prognostic for survival in small-cell lung cancer (SCLC). This study aimed to validate this finding, build prediction model overall (OS) and whether novel models that combine lymphocyte-related variables can predict OS more accurately than a conventional using clinical factors alone large cohort of limited-stage SCLC patients.This enrolled 544 patients receiving definitive chemo-radiation with pre-radiotherapy including...
Purpose: Disparities in cancer care delivery remain a pressing health-care crisis within the United States (US). The use of immune checkpoint inhibitors (ICIs) and their management may be disparity generator that impacts survival. This retrospective study assessed disparities cohort patients with variety solid tumors treated ICIs single organization focusing on impact race, socioeconomic status (SES) site survival development severe immune-related adverse events (irAEs). Patients Methods:...
There is an increased risk of congestive heart failure (CHF) following anthracycline-based chemotherapy in patients with Diffuse Large B-cell lymphoma (DLBCL). Little known about factors CHF, other cardiovascular events (CVE), and CVE effect on outcomes. We conducted a retrospective review 463 newly diagnosed DLBCL treated between 2002 2016 anthracycline containing regimens. At median follow up 71.3 months, 10.4% developed new 4.97% had atrial fibrillation 3.2% coronary artery disease. Age...
Ustilago maydis infection is a serious disease affecting corn crops worldwide. Sterol 14α-demethylase (CYP51) one of the key enzymes sterol biosynthesis and an effective target antifungal drugs. To further study interaction between CYP51 drugs exploit more specific inhibitor (DMI) fungicides for U. maydis, in this homology modeling from (UmCYP51) templated as eukaryotic orthologues (the human CYP51) screening new DMI based on optimized expression were carried out first time. In addition,...
Bladder cancer prognosis remains dismal due to lack of appropriate biomarkers that can predict its progression. The study aims identify novel prognostic associated with the progression bladder by utilizing three Gene Expression Omnibus (GEO) datasets screen differentially expressed genes (DEGs). A total 1516 DEGs were identified between non-muscle invasive and muscle specimens. To value, we performed gene ontology (GO) Kyoto Encyclopedia Genes Genomes (KEGG) analysis. seven genes, including...
Cross-spectral face verification between short-wave infrared (SWIR) and visible light (VIS) images poses a challenge, which is motivated by various real-world applications such as surveillance at night time or in harsh environments. This paper proposes hybrid solution that takes advantage of both traditional feature engineering modern deep learning techniques to overcome the issue limited imagery encountered SWIR band. Firstly, revisits theory measurement levels. Then, two new operators are...
Background: Immune thrombotic thrombocytopenic purpura (iTTP) is a rare, life-threatening disorder managed with plasma exchange (PLEX) and steroids. Addition of rituximab (RTX) to initial disease treatment has been shown lower future relapse rates. Information as whether upfront cyclophosphamide (CTX) helpful in reducing not known. Methods: In retrospective cohort study, we identified all patients at our institution diagnosed iTTP between 2010 2019. We analyzed outcomes cumulative incidence...