A5072606310- X-ray Diffraction in Crystallography
- Crystallization and Solubility Studies
- DNA and Nucleic Acid Chemistry
- Light effects on plants
- DNA Repair Mechanisms
- Photosynthetic Processes and Mechanisms
- Gold and Silver Nanoparticles Synthesis and Applications
- Advanced biosensing and bioanalysis techniques
- Biosensors and Analytical Detection
- Polar Research and Ecology
- Polymer Surface Interaction Studies
- Protein Structure and Dynamics
- RNA and protein synthesis mechanisms
- Alzheimer's disease research and treatments
- Melamine detection and toxicity
- Epigenetics and DNA Methylation
- Electrospun Nanofibers in Biomedical Applications
- Photochemistry and Electron Transfer Studies
- Supercapacitor Materials and Fabrication
- Carcinogens and Genotoxicity Assessment
- Supramolecular Chemistry and Complexes
- Advanced Sensor and Energy Harvesting Materials
- Enzyme Structure and Function
- Lipid Membrane Structure and Behavior
- Plasmonic and Surface Plasmon Research
Ningbo Institute of Industrial Technology
2024
Chinese Academy of Sciences
2024
University of Chinese Academy of Sciences
2024
Wenzhou Medical University
2024
University of Alberta
2017-2023
State Key Laboratory of Respiratory Disease
2022
Guangzhou Medical University
2021-2022
Central South University
2008-2022
Sinopec (China)
2021-2022
Zhuzhou Central Hospital
2022
Portable devices with the advantages of rapid, on-site, user-friendly, and cost-effective assessment are widely applied in daily life. However, only a limited number quantitative portable commercially available, among which personal glucose meter (PGM) is most successful example has been used. PGMs can detect blood as unique target. Here we describe novel design that combines glucoamylase-trapped aptamer-cross-linked hydrogel PGM for detection non-glucose targets. Upon target introduction,...
A target-responsive aptamer-cross-linked hydrogel was designed and synthesized for portable visual quantitative detection of the toxin Ochratoxin (OTA), which occurs in food beverages. The network forms by hybridization between one DNA strand containing OTA aptamer two complementary strands grafting on linear polyacrylamide chains. Upon introduction OTA, binds with leading to dissociation hydrogel, followed release preloaded gold nanoparticles (AuNPs), can be observed naked eye. To enable...
Drugs that recapitulate aspects of the exercise adaptive response have potential to provide better treatment for diseases associated with physical inactivity. We previously observed reduced skeletal muscle class IIa HDAC (histone deacetylase) transcriptional repressive activity during exercise. Here, we find exercise-like adaptations are induced by expression mutants cannot form a corepressor complex. Adaptations include increased metabolic gene expression, mitochondrial capacity, and lipid...
Marine biofouling is one of the technical bottlenecks restricting development global marine economy. Among commercial self-polishing antifouling coatings, cuprous oxide an irreplaceable component because its efficiency and broad-spectrum antibacterial activity. However, biggest obstacles to achieving long-term "initial burst final decay" in coating. Here, we lock copper ions by establishing unit composed Cu2O (core) Cu-based metal-organic framework (Cu-MOF, shell). Cu-MOF densely grown situ...
Solar UV‐B (280–315 nm) radiation is a developmental signal in plants but may also cause oxidative stress when combined with other environmental factors. Using computer modeling and solution experiments we show that capable of photosensitizing hydroxyl radical production from hydrogen peroxide. We present evidence the effect leaves at least twofold: (i) it increases cellular peroxide concentrations, to larger extent pyridoxine antioxidant mutant pdx1.3‐1 Arabidopsis and; (ii) partial...
Abstract Magnetic poly(styrene butyl acrylate methacrylic acid) [P(St–BA–MAA)] microspheres were prepared by emulsifier‐free emulsion polymerization in the presence of a polar solvent and ferrofluid coprecipitation method. The effects some parameters, such as medium polarity, reaction temperature, initiator content, surfactant content ferrofluid, on particle diameter size distribution magnetic P(St–BA–MAA) examined detail. results showed that electrostatic repulsion system significantly...
A homology model of the Arabidopsis thaliana UV resistance locus 8 (UVR8) protein is presented herein, showing a seven-bladed β-propeller conformation similar to globular structure RCC1. The UVR8 amino acid sequence contains very high amount conserved tryptophans, and shows that seven these tryptophans cluster at 'top surface' where they are intermixed with positive residues (mainly arginines) couple tyrosines. Quantum chemical calculations excitation spectra both large involving all twelve...
Because of either thermal/chemical instability or high optical loss in noble metal nanostructures, searching for alternative plasmonic materials is becoming more and urgent, considering the practical biosensing applications under various extreme conditions. In this work, titanium nitride (TiN), a low-loss metal-like material with both excellent thermal chemical stabilities, was proposed to composite Ag hollow nanosphere (HNS) nanostructures as an effective surface-enhanced Raman scattering...
Mussel-inspired polydopamine (PDA) deposition provides a prominent approach for constructing functional coatings, which has received much research interest over the past decade. However, large PDA aggregates often formed and precipitated from solution during process, significantly lowering utilization efficiency of dopamine surface modification. It is both fundamental practical importance to "reactivate" reuse achieve higher usage in modifications. In this work, we report facile,...
The Arabidopsis thaliana UV RESISTANCE LOCUS8 (UVR8) protein has been identified to specifically mediate photomorphogenic UV-B responses by acting as a photoreceptor. dimeric structure of the UVR8 dissociates into signaling-active monomers upon exposure, and rapidly interact with downstream signaling components regulate gene expression. revert dimers in absence radiation, thereby reversing transcription activation. amino acid residues W233 W285 have play critical roles dimer for response...
Hydrogen-bonding interaction is one of the most developed approaches for generating supramolecular polymers, and self-assemblies solely based on hydrogen bonds are generally unstable in water. Although considerable efforts have been made to improve stability hydrogen-bonded arrays by other interactions such as hydrophobic interactions, it still remains a challenge elucidate effects surrounding environment bonding at single-molecular level, which crucial developing desired structures. In this...
A key issue in the nucleotide excision repair (NER) of bulky carcinogen–DNA adducts is ability NER machinery to recognize and certain while failing others. Unrepaired can survive cause mutations that initiate carcinogenic process. Benzo[c]phenanthrene (B[c]Ph), a representative fjord region polycyclic aromatic hydrocarbon, be metabolically activated enantiomeric benzo[c]phenanthrene diol epoxides (B[c]PhDEs), (+)‐(1S,2R,3R,4S)‐3,4‐ dihydroxy‐1,2‐epoxy‐1,2,3,4‐tetrahydrobenzo[c]phe nanthrene...
Computing accurate absorption spectra of riboflavin (RBF) has proven a difficult task for computational chemistry. Time-dependent density functional theory have herein been employed using wide range recent range-separated and hybrid meta functionals to investigate ultraviolet visible RBF determine if any progress made through developments. It is concluded that B3LYP PBE0 perform the best throughout entire test set. However, since all methods deviate from experimental results by at least 40...
Circular RNA (circRNA) had been confirmed to participate in ulcerative colitis (UC) development. RNA_0001187 (Circ_0001187) found be overexpressed patients with Crohn disease. Therefore, circ_0001187 might an important circRNA regulating intestinal inflammatory diseases. However, the role and mechanism of UC progression remains unclear. The colonic mucosal tissues were obtained from 23 healthy normal controls. Tumor necrosis factor-α (TNF-α) was used mimic cell model vitro. Cell function...
The initial step in initiation of eukaryotic DNA replication involves the assembly pre-replicative complexes (pre-RCs) at origins during G1 phase cell cycle. In metazoans is inhibited by regulatory factor Geminin. We have purified human pre-RC proteins, studied their interactions vitro with each other and origin DNA, analyzed effects HsGeminin on formation DNA-protein complexes. an complex containing recognition (HsORC), HsCdt1, HsCdc6, cooperative, involving all possible binary among...
Two different reaction types for the photolysis of pyridoxine-aromatic ring-opening and photodissociation-have been studied in Density Functional Theory (DFT) framework. Our results show that neither photolytic ring-opening, dehydroxymethylation, demethylation nor dehydroxylation from aromatic ring can be induced spontaneously UV-irradiated pyridoxine, due to high barriers along coordinates excited states. However, simultaneous C4-bound hydroxymethyl group dehydrogenation bound hydroxyl...