A5084772347- RNA and protein synthesis mechanisms
- Molecular Biology Techniques and Applications
- Mosquito-borne diseases and control
- Sarcoma Diagnosis and Treatment
- Multiple Myeloma Research and Treatments
- Glycosylation and Glycoproteins Research
- Insect symbiosis and bacterial influences
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- Genetics, Bioinformatics, and Biomedical Research
- RNA regulation and disease
- Acute Myeloid Leukemia Research
- Advanced Proteomics Techniques and Applications
- RNA Research and Splicing
University of North Carolina at Chapel Hill
2023-2025
Linfield College
2016
Oregon Health & Science University
2015
University of Glasgow
2007
King's College London
2007
Abstract Biomolecules continually sample alternative conformations. Consequently, even the most energetically favored ground conformational state has a finite lifetime. Here, we show that, in addition to 3D structure, lifetime of determines its biological activity. Using hydrogen-deuterium exchange nuclear magnetic resonance spectroscopy, found that Zika virus exoribonuclease-resistant RNA (xrRNA) encodes with is ~10 5 –10 7 longer than canonical base pairs. Mutations shorten apparent...
Ewing's Sarcoma is a pediatric bone cancer that affects approximately 3 in 1,000,000 children each year. The prognosis for patient can be very poor due to the extremely aggressive and metastatic nature of cells. Treatment patients with this typically includes surgery, radiation, and/or chemotherapy. EWS‐Fli1, chromosomal translocation product responsible development Sarcoma, has been shown upregulate transcription Aurora kinases, group serine kinases. actin‐binding protein cortactin an...