A5053699810- Neuropeptides and Animal Physiology
- Receptor Mechanisms and Signaling
- Regulation of Appetite and Obesity
- Biochemical effects in animals
- Biochemical Analysis and Sensing Techniques
- Apelin-related biomedical research
- Neuroendocrine regulation and behavior
- Archaeology and ancient environmental studies
- Hungarian Social, Economic and Educational Studies
- Sleep and Wakefulness Research
- Protein Hydrolysis and Bioactive Peptides
- Diet, Metabolism, and Disease
- Ancient and Medieval Archaeology Studies
- Adipose Tissue and Metabolism
- Forensic and Genetic Research
- Genetic diversity and population structure
- Pharmacological Effects and Assays
- Neurotransmitter Receptor Influence on Behavior
- Pacific and Southeast Asian Studies
- Environmental Chemistry and Analysis
- Renin-Angiotensin System Studies
- Sleep and related disorders
- Rabbits: Nutrition, Reproduction, Health
- Horticultural and Viticultural Research
- Coagulation, Bradykinin, Polyphosphates, and Angioedema
Campbell University
2019-2023
Duke University
2017-2022
Duke University Hospital
2017-2022
Duke Medical Center
2017-2022
University of Pecs
2006-2012
Hungarian Academy of Sciences
2006
Abstract The Linearbandkeramik (LBK) Neolithic communities were the first to spread farming across large parts of central Europe, settling fertile regions from Ukraine France during second half 6th millennium BCE. LBK had a high degree material culture uniformity, albeit with regional differences in settlement patterns, subsistence, and mortuary practices. To date, ancient DNA data individuals have been generated for limited number locations often small sample sizes, making it challenging...
Genetically tractable animal models provide needed strategies to resolve the biological basis of drug addiction. Intravenous self-administration (IVSA) is gold standard for modeling psychostimulant and opioid addiction in animals, but technical limitations have precluded widespread use IVSA mice. Here, we describe paradigms mice that capture multi-stage nature disorder permit predictive modeling. In these paradigms, C57BL/6J with long-standing indwelling jugular catheters engaged cocaine- or...
SignificanceThe modulation of growth hormone secretagogue receptor-1a (GHSR1a) signaling is a promising strategy for treating brain conditions metabolism, aging, and addiction. GHSR1a activation results in pleiotropic physiological outcomes through distinct pharmacologically separable G protein- β-arrestin (βarr)-dependent pathways. Thus, pathway-selective can enable improved pharmacotherapeutics that promote therapeutic efficacy while mitigating side effects. Here, we describe the discovery...
The signaling scaffold protein GIT1 is expressed widely throughout the brain, but its function in vivo remains elusive. Mice lacking have been proposed as a model for attention deficit-hyperactivity disorder, due to alterations basal locomotor activity well paradoxical suppression by psychostimulant amphetamine. Since we had previously shown that GIT1-knockout mice normal activity, here examined GIT1-deficient ADHD-like behavior more detail, and find neither hyperactivity nor...
The "brain-gut" peptide ghrelin, which mediates food-seeking behaviors, is recognized as a very strong endogenous modulator of dopamine (DA) signaling. Ghrelin binds the G protein-coupled receptor GHSR1a, and administration ghrelin increases rewarding properties psychostimulants while antagonists decrease them. In addition, GHSR1a signals through βarrestin-2 to regulate actin/stress fiber rearrangement, suggesting participation in regulation actin-mediated synaptic plasticity for addictive...
Abstract Dietary reconstruction is used to make inferences about the subsistence strategies of ancient human populations, but it may also serve as a proxy characterise their diverse cultural and technological manifestations. Dental microwear stable isotope analyses have been shown be successful techniques for paleodietary populations but, despite yielding complementary dietary information, these rarely combined within same study. Here we present first time comprehensive approach interpreting...
G-protein-coupled receptors (GPCRs) can bias signaling through distinct biochemical pathways that originate from G-protein/receptor and β-arrestin/receptor complexes. Receptor conformations supporting β-arrestin engagement depend on multiple receptor determinants. Using ghrelin GHR1a, we demonstrate by bioluminescence resonance energy transfer fluorescence microscopy a critical role for its second intracellular loop 2 (ICL2) domain in stabilizing β-arrestin/GHSR1a core interactions...
ABSTRACT A genetically tractable animal model would provide a needed strategy to resolve the biological basis of drug addiction. Intravenous self-administration (IVSA) is gold standard for modeling cocaine and opioid addiction in animals, but technical limitations have precluded widespread use IVSA mice. Here, we describe first paradigms mice that capture multi-stage nature disease permit predictive modeling. Mice with long-standing indwelling jugular catheters engaged or opioid-associated...
The Roman Catholic Status of Transylvania is an institution that still operates today and has a long history. present study reviews slice the history Board Directors Status, which was leading group institution. research bears peculiarities church research, using available resources, taking into account characteristics period as well. text contains excerpts from contemporary protocols drafts, well archival documents. When rewriting, we retained terms original spelling, this way can more...
Pharmacy education poses significant challenges and obstacles for students and, ultimately, the profession of pharmacy. Increasing attrition failure rates in pharmacy schools are a concerning trend, these issues projected to worsen future. Multiple factors contribute outcomes, including lingering effects COVID-19 pandemic, lack preparedness, motivation, outside distractions, fragility. Nonetheless, failures provide valuable opportunities growth learning. To succeed education, require...