A5037457746- Geochemistry and Elemental Analysis
- Osteoarthritis Treatment and Mechanisms
- Heavy metals in environment
- Inflammatory mediators and NSAID effects
- Isotope Analysis in Ecology
- Mercury impact and mitigation studies
- Geology and Paleoclimatology Research
- Catalytic C–H Functionalization Methods
- Geochemistry and Geologic Mapping
- Cyclopropane Reaction Mechanisms
- Synthetic Organic Chemistry Methods
- Neuropeptides and Animal Physiology
- Cell Adhesion Molecules Research
- Paleontology and Stratigraphy of Fossils
- Chemical Synthesis and Reactions
- Total Knee Arthroplasty Outcomes
- Orthopaedic implants and arthroplasty
- Crystallization and Solubility Studies
- Spine and Intervertebral Disc Pathology
- Orthopedic Infections and Treatments
- Marine and coastal ecosystems
- Radioactive element chemistry and processing
- Catalytic Alkyne Reactions
- Groundwater and Isotope Geochemistry
- Asymmetric Synthesis and Catalysis
Kitasato University
2015-2024
Kyoto University Institute for Chemical Research
2013-2024
Kyoto University
2014-2024
University of Cambridge
2024
Kyoto Bunkyo University
2013-2024
Instituto de Investigaciones Químicas
2016-2024
Banaras Hindu University
2022
Fukushima Medical University
2022
Keio University
2016-2021
Tohoku University
1988
Natural variations in the isotopic composition of molybdenum (Mo) are showing increasing potential as a tool geochemistry. Although ocean is an important reservoir Mo, data on Mo seawater scarce. We have recently developed new method for precise determination isotope ratios basis preconcentration using chelating resin and measurement by multiple-collector inductively coupled plasma mass spectrometry (MC-ICP-MS), which allows us to measure every stable (Nakagawa et al., 2008). In this study,...
We have prepared and calibrated a large volume of pure, concentrated homogenous zinc standard solution.
To investigate the role of macrophages as a regulator and producer nerve growth factor (NGF) in synovial tissue (ST) osteoarthritis (OA) joints, gene expression profiles several inflammatory cytokines ST, including fibroblasts, OA mice (STR/Ort) were characterized. Specifically, real-time polymerase chain reaction analysis was used to evaluate tumor necrosis factor- (TNF-) α , interleukin- (IL-) 1 β IL-6, NGF CD11b+ CD11b– cells isolated from ST murine model. The effects TNF- IL-1 IL-6 on...
Abstract We developed a new scaffold material—oriented collagen tubes (OCT)—and evaluated the potential of OCTs combined with basic fibroblast growth factor (bFGF) to repair 15 mm sciatic nerve defect in rats. The treatment groups consisted OCT adsorbed bFGF (OCT/bFGF group), phosphate‐buffered saline (PBS) (OCT/PBS and no‐treatment group (Defect group). Functional evaluation regeneration was performed using CatWalk system, histological analyses sites were also performed. In rats treated...
Research suggests that vascular endothelial growth factor (VEGF) levels in the synovial fluid of knee osteoarthritis (KOA) patients are positively correlated with KOA severity. The relationship between VEGF and pain human is not fully understood, role pathway remains unclear. We harvested membrane (SM) from 102 radiographic evidence (unilateral Kellgren/Lawrence [K/L] grade 2–4) during total arthroplasty. Patients scored their on a 0 to 10 cm visual analog scale (VAS). SM strong/severe (VAS...
Abstract The North Pacific has played an important role in ongoing discussions on the origin of global correlation between oceanic dissolved Zn and Si, while data have remained sparse. Here, we present δ 66 from US GEOTRACES GP15 meridional transect along 152°W Alaska to South Pacific. In south (<20°N) Si exhibit a tight linear reflecting strong Southern Ocean influence, north (>20°N) excess relative upper intermediate waters is due regeneration together with PO 4 . Using mechanistic...
Abstract. The deposition of dissolved iron (d-Fe) from East Asian aerosols to the North Pacific Ocean modulates primary productivity in surface waters, facilitating uptake atmospheric carbon dioxide by ocean, thereby impacting global climate. Since microorganisms seawater utilize d-Fe as a micronutrient, bioavailability aerosol Fe depends on its solubility (Fesol%). Although Fesol% is influenced both emission sources and processing, their effects are not fully understood. We assessed factors...
ABSTRACT Upregulation of inflammatory cytokines and various growth factors is a significant contributor to discogenic low back pain. The aim this study was investigate possible regulation pain‐related molecules by macrophages the role macrophage‐derived in injured intervertebral disc (IVD)s. C57BL/6J mice were used study. We characterized expression profiles genes for tumor necrosis factor (TNF)‐alpha, interleukin (IL)‐1beta, nerve (NGF), vascular endothelial (VEGF) both intact IVDs....
Abstract We determined Zn isotope composition (δ 66 Zn) in the water column of Northwestern Pacific Ocean (NWPO) and its marginal seas to investigate processes driving vertical spatial variations. Comparable previous studies, dissolved δ was relatively low top 200 m, ranging from −0.91 +0.24‰ increased with depth toward an averaged value, +0.38±0.10‰, deep water. found that observed NWPO much lower than Northeastern Ocean. Box model approaches suggest variations may be attributed...
Recent studies suggest that the vasodilatory neuropeptide calcitonin gene-related peptide (CGRP) is localized in synovial tissue and may be involved pathology of hip knee osteoarthritis (OA). However, regulation relationship between pain CGRP expression levels human OA patients are not fully understood.Synovial tissues were harvested from 74 participants with radiographic (unilateral Kellgren/Lawrence grades 3-4) during total arthroplasty. CGRP-expressing cells resected identified by...
Aluminum (Al), manganese (Mn), cobalt (Co), and lead (Pb) are strongly scavenged from seawater. We reported that each element is uniquely related to ocean circulation in the North Pacific (Zheng et al., 2019). Herein, we present full-depth distributions of these elements western South Pacific, which include meridional sections along 170°W (GEOTRACES GP19). determined dissolved (d) total dissolvable (td) concentrations using filtered unfiltered seawater without UV treatment, calculated labile...
Calcitonin gene-related peptide (CGRP) is a 37-amino-acid vasodilatory neuropeptide that binds to receptor activity-modifying protein 1 (RAMP1) and the calcitonin receptor-like (CLR). Clinical preclinical evidence suggests CGRP associated with hip knee joint pain; however, regulation mechanisms of CGRP/CGRP signaling in synovial tissue are not fully understood.Synovial tissues were harvested from 43 participants radiographic osteoarthritis (OA; unilateral Kellgren/Lawrence (K/L) grades 3-4)...
Abstract The North Pacific Ocean is located at the end of thermohaline circulation deep water. This study reports on basin‐scale full‐depth sectional distributions total dissolvable (td), dissolved (d), and labile particulate (lp) Cd, Ni, Zn, Cu along three transects: GEOTRACES transects GP18 (165°E) GP02 (47°N), 160°W. We find that scavenging an important factor significantly affects dZn, dNi, dCu, which magnitude influence increases in order Cd < Zn Cu. relationships between four metals...
Recent studies have reported that calcitonin gene-related peptide (CGRP) contributes to joint pain. However, regulation of the CGRP/CGRP receptor signalling in osteoarthritis (OA) is not fully understood. To investigate by macrophages synovial tissue (ST) OA joints, we characterized gene expression profiles CGRP and receptors ST mice (STR/Ort). In addition, examined whether macrophage depletion systemic injection clodronate-laden liposomes affected ST. CD11c(+) STR/Ort C57BL/6J were analysed...
8-Quinolinolate is a monoanionic, hard, strongly σ-donating ligand that can form strong chelates with various metals. However, studies of the catalytic activities soft transition metal complexes such as greater than second row, low-valent, late-transition metals having 8-quinolinolate ligands had not been well explored until recently. In recent years, several research groups including our own have studied and developed reactions terminal alkynes using rhodium(I) catalysts containing an...