A5056599077- Medical Practices and Rehabilitation
- Intensive Care Unit Cognitive Disorders
- Musculoskeletal Disorders and Rehabilitation
- Long-Term Effects of COVID-19
- Lymphatic System and Diseases
- Respiratory Support and Mechanisms
- Health and Medical Studies
- Myofascial pain diagnosis and treatment
- HIV Research and Treatment
- Dupuytren's Contracture and Treatments
- Immune Cell Function and Interaction
- Biomedical and Chemical Research
- Cerebral Palsy and Movement Disorders
- Psychiatric care and mental health services
- Thermoregulation and physiological responses
- Fibromyalgia and Chronic Fatigue Syndrome Research
- Healthcare Decision-Making and Restraints
- Diagnosis and Treatment of Venous Diseases
- Thermal Regulation in Medicine
- Immunotherapy and Immune Responses
- vaccines and immunoinformatics approaches
- Innovations in Medical Education
- Medical and Health Sciences Research
- Trauma and Emergency Care Studies
- Emergency and Acute Care Studies
Charité - Universitätsmedizin Berlin
2016-2025
Freie Universität Berlin
2019-2025
Humboldt-Universität zu Berlin
2019-2025
Martin Luther University Halle-Wittenberg
2017
Ludwig-Maximilians-Universität München
2004
University of Wisconsin–Madison
2000-2003
Certain major histocompatibility complex class I (MHC-I) alleles are associated with delayed disease progression in individuals infected human immunodeficiency virus (HIV) and macaques simian (SIV). However, little is known about the influence of these MHC on acute-phase cellular immune responses. Here we follow 51 animals SIV(mac)239 demonstrate a dramatic association between Mamu-A*01 -B*17 expression slowed progression. We show that dominant cytotoxic T lymphocyte (CTL) responses...
It is becoming increasingly clear that any human immunodeficiency virus (HIV) vaccine should induce a strong CD8(+) response. Additional desirable elements are multispecificity and focus on conserved epitopes. The use of multiple epitopes arranged in an artificial gene (or EpiGene) potential means to achieve these goals. To test this concept relevant disease model we sought identify simian (SIV)-derived bound by single nonhuman primate major histocompatibility complex (MHC) class I molecule....
ABSTRACT Cytotoxic T-lymphocyte (CTL) responses are thought to control human immunodeficiency virus replication during the acute phase of infection. Understanding CD8 + T-cell immune early after infection may, therefore, be important vaccine design. Analyzing these in humans is difficult since few patients diagnosed Additionally, infected by a variety viral subtypes, making it hard design reagents measure their acute-phase responses. Given complexities evaluating humans, we analyzed rhesus...
ABSTRACT The regulatory proteins of human immunodeficiency virus may represent important vaccine targets. Here we assessed the role Tat-specific cytotoxic T lymphocytes (CTL) in controlling pathogenic simian SIVmac239 replication after using a DNA-prime, vaccinia Ankara-boost regimen. Despite induction CTL, there was no significant reduction either peak or viral set point compared to that controls.
Abstract Around 6.2% of patients report symptoms as fatigue, muscle pain and dyspnea more than three months after SARS-CoV-2 infection, defined post COVID-19 condition (PCC). Non-hospitalized with PCC often show normal pulmonary functioning tests imaging but suffer from respiratory symptoms. On clinical examination, signs diaphragmatic dysfunction. The study aimed to objectively visualize quantify the function using sonographic parameters in without dyspnea. Adult were prospectively assessed...
To evaluate non-inferiority of adjustable compression wraps compared to inelastic multilayer bandaging in reducing lower leg volume during intensive complex decongestive therapy patients with bilateral, symmetrical lymphedema. Secondary outcomes included application time, patient comfort, and side effects. A prospective, randomized controlled trial was conducted on 24 stage II-III bilateral lymphedema a 10-day therapy. Each received side, while the contralateral treated bandages. The primary...
Zusammenfassung In der Entstauungsphase Komplexen Physikalischen Entstauungstherapie des Lymphödems (KPE Phase I) werden verschiedene Untermaterialien eingesetzt, um die Anlage Kurzzugbinden zu stabilisieren und Haut schützen. Eine neuartige Form Unterpolsterung bieten mit Baumwolle umnähte Schaumstoffbandagen. Deren Therapieeffekte sind jedoch bislang nicht untersucht. Prospektive, randomisierte Nichtunterlegenheitsstudie an Proband/innen sekundärem Armlymphödem. Die Kontrollgruppe erhielt...
Abstract The SIV-infected rhesus macaque is an excellent model to examine candidate AIDS virus vaccines. These vaccines should elicit strong CD8+ responses. Previous definition of the peptide-binding motif and optimal peptides for Mamu-A*01 has created a demand Mamu-A*01-positive animals. We have now studied second MHC class I molecule, Mamu-B*17, that present in 12% captive-bred Indian macaques. specificity Mamu-B*17 molecule was characterized using single substitution analogs two...
Dieses gemeinsame Positionspapier der 3 Fachgesellschaften Bundesarbeitsgemeinschaft Akutkrankenhäuser mit Abteilungen für fachübergreifende Frührehabilitation (BAG Frührehabilitation), Berufsverband Rehabilitationsärzte Deutschlands (BVPRM) und Deutsche Gesellschaft Physikalische Medizin Rehabilitation (DGPMR) stellt den aktuellen Stand, die Perspektiven notwendige Maßnahmen zur Weiterentwicklung fachübergreifenden dar. ist frühestmöglich einsetzende Therapie in Kombination aus...
Abstract Background Neuromuscular electrical stimulation (NMES) has been investigated as a preventative measure for intensive care unit-acquired weakness. Trial results remain contradictory and therefore inconclusive. As it shown that NMES does not necessarily lead to contractile response, our aim was characterise the response of critically ill patients investigate potential outcome benefits an adequate response. Methods This is sub-analysis randomised controlled trial investigating early...
Zusammenfassung Während der COVID-19-Pandemie stehen Rehabilitationskliniken und Akutkliniken bezüglich physikalisch-medizinischer, physiotherapeutischer frührehabilitativer Versorgung vor neuen Herausforderungen. In Behandlung von COVID-19 ist einer Notwendigkeit frühmobilisierender Maßnahmen auszugehen, auch wenn vorhandene Strukturen bislang nicht flächendeckend solche Komplexbehandlungen vorsahen. Aus den Erfahrungen aus fachübergreifenden Frührehabilitation in Patienten mit...
We determined the effect of wearing clothes under manometer's cuff on blood pressure in manual auscultatory sphygmomanometric and automatic oscillometric measurement.Two hundred one subjects were examined with method, each without sleeved arm random order. The readings blinded for subjects' state clothing. Common shirts sweaters (thinner than 2 mm) used.Based confidence intervals differences between non-sleeved measurements equivalence test, sleeves did not lead to statistically significant...
Mobility is an essential part of a person's functioning and independence. It encompasses locomotive functions, but also the more basic functions positioning transferring. Despite availability several mobility-related assessment instruments to date, there need for with specific capability display full range mobilisation. Our aim was develop validate scoring instrument hierarchical composition where every score value stands defined mobility level.A previously developed validated pilot applied...
The learning objectives in the current cross-sectional subject "Rehabilitation, Physical Medicine, Naturopathic Medicine" have been revised as part of further development National Competency-Based Catalogue Learning Objectives for Medicine (NKLM) to its new version 2.0. Since NKLM is designed an interdisciplinary catalogue, a assignment seemed necessary from point view various stakeholders. Thus, German Association Scientific Medical Societies (AWMF) and medical faculties initiated process....
Survivors of severe COVID-19 often exhibit a variety sequelae including loss mobility and ADL (activities daily living) capacity. Acute rehabilitation (AR) is an interdisciplinary intervention applied early while still in hospital setting. The goal AR to improve functional limitations increase independence at discharge. It established the treatment patients with other diseases such as sepsis, polytrauma, or stroke. Data concerning are sparse.
<b>Hintergrund:</b> Frührehabilitation ist der frühestmögliche Einsatz Rehabilitation im Akutverlauf. Sie schließt in Versorgung des Polytraumas die Rehabilitationslücke zwischen unfallchirurgischer und Rehabilitationsklinik. <b>Material Methoden:</b> 50 Polytraumafälle mit anschließender fachübergreifender auf einer eigenen Frührehabilitations-Station wurden retrospektiv analysiert. Als primäre Outcome-Parameter Mobilität (Charité Mobility Index<sup>®</sup>) ADL-Kompetenz (Barthel-Index)...
Ziel der Untersuchung war die Evaluation Wirkung von elastischem Tape bei Lymphödemen in Erhaltungsphase Komplexen Physikalischen Entstauungstherapie. Es wurde eine prospektive, randomisiert-kontrollierte, 3-armige Studie mit einem Interventionszeitraum 12 Wochen geplant. Während Kontrollgruppe reguläre KPE Phase II fortgeführt wurde, Interventionsgruppe A <i>additiv</i> Tape, welches unter vorhandenen Kompression getragen behandelt. Die B erhielt das elastische <i>anstelle</i> Kompression....
Background: Little is known of the impact in terms health-related quality life (HRQoL) and cost-effectiveness with decongestive therapy. Objectives: To examine changes limb volume, (QoL), treatment cost methods lymphatic therapy (DLT). Methods: Patients chronic edema/lymphedema leg were invited to participate a study DLT four countries (United Kingdom, France, Germany, Canada). In each country two sites selected. One site used their standard method service, including compression multilayer...
Drug Prescribing for Patients with Chronic Kidney Disease in General Practice: a Cross-Sectional Study
Veränderungen in der Medizin, wie bspw. Zuwachs Wissensbasis und die Verschiebungen Epidemiologie, haben naturgemäß auch Auswirkungen auf das Selbstverständnis von Facharztgruppen. Dies aktuelle Theoriebildung zu Behinderung Funktionsfähigkeit hat erheblichen Einfluss Praxis Physikalischen Rehabilitativen Medizin (PRM). In dem vorliegenden Artikel soll Tätigkeitsbereich des Facharztes für PRM beschrieben an klinischen Beispielen demonstriert werden. Nach internationaler Definition umfasst...