A5044855910- Genetic diversity and population structure
- Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities
- Genetic Mapping and Diversity in Plants and Animals
- Animal Ecology and Behavior Studies
- Chromosomal and Genetic Variations
- Genetic and phenotypic traits in livestock
- Animal Behavior and Reproduction
- Bat Biology and Ecology Studies
- Evolution and Paleontology Studies
- Animal Genetics and Reproduction
- Wildlife Ecology and Conservation
- Genomics and Chromatin Dynamics
- Evolution and Genetic Dynamics
- Genomics and Phylogenetic Studies
- Isotope Analysis in Ecology
- Physiological and biochemical adaptations
- Primate Behavior and Ecology
- CRISPR and Genetic Engineering
- Marine animal studies overview
- Sperm and Testicular Function
- Yersinia bacterium, plague, ectoparasites research
- Plant and animal studies
- Mitochondrial Function and Pathology
- Genetics and Physical Performance
- Retinal Development and Disorders
University of Michigan–Ann Arbor
2010-2023
American Museum of Natural History
2015
Institute of Zoology
2012
Jackson Laboratory
1989-1992
University of California, Berkeley
1992
Museum of Vertebrate Zoology
1992
Texas A&M University
1981-1989
ABSTRACT We have identified Math5, a mouse basic helix-loop-helix (bHLH) gene that is closely related to Drosophila atonal and Xenopus Xath5 largely restricted the developing eye. Math5 retinal expression precedes differentiation of first neurons persists within progenitor cells until after birth. To position in hierarchy development, we compared Hes1 wild-type Pax6-deficient (Sey) embryos. downregulated Sey/+ eyes abolished Sey/Sey eye rudiments, whereas bHLH upregulated similar...
Hybrid zones between closely related species or subspecies provide useful settings for studying the genetic architecture of speciation. Using markers distributed throughout mouse genome, we use a hybrid zone two recently diverged house mice (Mus musculus and Mus domesticus) as natural mapping experiment to identify genomic regions that may be involved in reproductive isolation. cline analysis document nearly 50-fold variation level introgression among markers. Some have extremely narrow...
Studies of the genetics hybrid zones can provide insight into genomic architecture species boundaries. By examining patterns introgression multiple loci across a zone, it may be possible to identify regions genome that have experienced selection. Here, we present comparison in two replicate transects through house mouse zone central Europe, using data from 41 single nucleotide markers. Using both and geographic clines, found many differences between transects, as well some similarities. We...
We compared the patterns of movement sex chromosomal and autosomal loci along a 160 km transect across zone hybridization between M. domesticus musculus in southern Germany western Austria using seven genetic markers. These included one Y‐specific DNA sequence (YB10), two X‐specific (DXWas68 DXWas31), four isozyme (Es‐10, Es‐1, Mpi‐1, Np‐1). Random effects logistic regression analysis enabled us to examine relationship allele frequency geographic distance from edge hybrid allowed statistical...
Studies of a hybrid zone between two house mouse subspecies (Mus musculus and M. m. domesticus) along with studies using laboratory crosses reveal large role for the X chromosome multiple autosomal regions in reproductive isolation as consequence disrupted epistasis hybrids. One limitation previous work has been that most identified genomic have large. The goal here is to detect characterize precise underlying isolation. We surveyed 1401 markers evenly spaced across genome 679 mice collected...
Cytological analysis of the mouse Y* chromosome revealed a complex rearrangement involving acquisition functional centromere and centromeric heterochromatin attachment this chromosomal segment to distal end normal Y chromosome. This positioned short-arm region at pseudoautosomal interstitially, just newly acquired centromere. In addition, majority was inverted. Recombination between X chromosomes generates two new sex chromosomes: (1) large comprised attached its all but missing...
Behavioural isolation may lead to complete speciation when partial postzygotic acts in the presence of divergent-specific mate-recognition systems. These conditions exist where Mus musculus and M. m. domesticus come into contact hybridize. We studied two signal systems, based on urinary salivary proteins, across a Central European portion mouse hybrid zone. Introgression genomic regions responsible for these signals: major proteins (MUPs) androgen binding (ABPs), respectively, was compared...
Genomic features such as rate of recombination and differentiation have been suggested to play a role in species divergence. However, the relationship these phenomena functional organization genome context reproductive isolation remains unexplored. Here, we examine genomic characteristics boundaries between two house mouse subspecies (Mus musculus musculus/M. m. domesticus). These taxa form narrow semipermeable zone secondary contact across Central Europe. Due incomplete nature isolation,...
Estimates of the proportion amino acid substitutions that have been fixed by selection (α) vary widely among taxa, ranging from zero in humans to over 50% Drosophila. This wide range may reflect differences efficacy due effective population size (N(e)). However, most comparisons made distantly related organisms differ not only N(e) but also many other aspects their biology. Here, we estimate α three closely lineages house mice a similar ecology N(e): Mus musculus (N(e) ∼ 25,000-120,000), M....
Several species in the rodent genus Mus are used as model research organisms, but comparative studies of these mice have been hampered by lack a well-supported phylogeny. We DNA sequences from six genes representing paternally, maternally, and biparentally inherited regions genome to infer phylogenetic relationships among 10 commonly laboratory research. Our sample included seven subgenus Mus; one each subgenera Pyromys, Coelomys, Nannomys; representatives three additional murine genera,...
Abstract Theory predicts that naturally occurring hybrid zones between genetically distinct taxa can move over space and time as a result of selection and/or demographic processes, with certain types being more or less likely to move. Determining whether zone is stationary moving has important implications for understanding evolutionary processes affecting interactions in populations. However, direct observations movement are difficult make unless the rapidly. Here, evidence house mouse Mus...
The house mouse hybrid zone (HMHZ) is a species barrier thought to be maintained by balance between dispersal and natural selection against hybrids. While the HMHZ characterized frequency discontinuities for some sex chromosome markers, there an unexpected large-scale regional introgression of Y across barrier, in defiance Haldane's rule. Recent work suggests that major force maintaining acts through sperm traits. Here, we test whether penetration traits assessing characteristics wild-caught...
Comparative genomic studies are now possible across a broad range of evolutionary timescales, but the generation and analysis data many different species still present number challenges. The most sophisticated genotyping down-stream analytical frameworks predominantly based on comparisons to high-quality reference genomes. However, established resources often limited within given group species, necessitating divergent genomes that could restrict or bias phylogenetic sample. Here, we develop...
Complete nucleotide sequences from the mitochondrial cytochrome b gene (1143 bp) were used to investigate phylogenetic relationships among native rodents of Madagascar. Specifically, this study examines whether nine genera nesomyines form a monophyletic group relative other Old World murids. All nesomyine genera, including multiple individuals 15 21 described species, included in analysis, and their monophyly was assessed murid subfamilies Mystromyinae, Petromyscinae, Dendromurinae,...
Lahn and Page previously observed that genes on the human X chromosome were physically arranged along in “strata,” roughly ordered by degree ofdivergence from related Y chromosome. They hypothesized this ordering results a historical series of suppressions ofrecombination mammalian chromosome, thereby allowing formerly recombining chromosomal to diverge independently. Here predictions ofthis hypothesis are confirmed nonprimate order, Rodentia, through an analysis ofeight gene pairs...
We compared the patterns of movement sex chromosomal and autosomal loci along a 160 km transect across zone hybridization between M. domesticus musculus in southern Germany western Austria using seven genetic markers.These included one Y-specific DNA sequence (YB 10), two X-specific (DXWas68 DXWas31), four isozyme (Es-1O, Es-1, Mpi-L, Np-l).Random effects logistic regression analysis enabled us to examine relationship allele frequency geographic distance from edge ofthe hybrid allowed...
Hybrid sterility in the heterogametic sex is a common feature of speciation animals. In house mice, contribution Mus musculus X chromosome to hybrid male large. It not known, however, whether F1 caused by X-Y or X-autosome incompatibilities combination both. We investigated M. domesticus Y cross between wild-derived strains which males with m. and are partially sterile, while from reciprocal reproductively normal. used eight introgression lines combine different genotypes chromosomes on an...
Abstract Summary: The eyeless inbred mouse strain ZRDCT has long served as a spontaneous model for human anophthalmia and the evolutionary reduction of eyes that occurred in some naturally blind mammals. mice have orbits but lack optic tracts hypothalamic abnormalities. Segregation data suggest small number interacting genes are responsible, including at least one major recessive locus, ey1 . Although predicted since 1940s, these loci were never identified. We mapped to chromosome 18 using...