A5022036207- Retinal Development and Disorders
- Adipose Tissue and Metabolism
- Developmental Biology and Gene Regulation
- Tryptophan and brain disorders
- Neuroendocrine regulation and behavior
- Neuroscience of respiration and sleep
- Neurotransmitter Receptor Influence on Behavior
- High Altitude and Hypoxia
- Stress Responses and Cortisol
- Retinopathy of Prematurity Studies
- Olfactory and Sensory Function Studies
- Nerve injury and regeneration
- Neuropeptides and Animal Physiology
- Anesthesia and Neurotoxicity Research
- Axon Guidance and Neuronal Signaling
- Cardiac Arrest and Resuscitation
- Animal testing and alternatives
- Mitochondrial Function and Pathology
- Muscle metabolism and nutrition
- Spaceflight effects on biology
- Ocular Disorders and Treatments
- Nicotinic Acetylcholine Receptors Study
- Adolescent and Pediatric Healthcare
- Forensic Toxicology and Drug Analysis
- Pain Mechanisms and Treatments
University of Utah
2008-2024
Mental Illness Research, Education and Clinical Centers
2018-2021
VA Rocky Mountain Network
2018-2021
VA Salt Lake City Healthcare System
2018-2021
Veterans Health Administration
2018
Allen Institute for Brain Science
2014
Myriad Genetics
2003
Rutgers, The State University of New Jersey
2001
University of Iowa
1993
ABSTRACT We have identified Math5, a mouse basic helix-loop-helix (bHLH) gene that is closely related to Drosophila atonal and Xenopus Xath5 largely restricted the developing eye. Math5 retinal expression precedes differentiation of first neurons persists within progenitor cells until after birth. To position in hierarchy development, we compared Hes1 wild-type Pax6-deficient (Sey) embryos. downregulated Sey/+ eyes abolished Sey/Sey eye rudiments, whereas bHLH upregulated similar...
Abstract Summary: The eyeless inbred mouse strain ZRDCT has long served as a spontaneous model for human anophthalmia and the evolutionary reduction of eyes that occurred in some naturally blind mammals. mice have orbits but lack optic tracts hypothalamic abnormalities. Segregation data suggest small number interacting genes are responsible, including at least one major recessive locus, ey1 . Although predicted since 1940s, these loci were never identified. We mapped to chromosome 18 using...
Kanekar, Shami, Olena V. Bogdanova, Paul R. Olson, Young-Hoon Sung, Kristen E. D'Anci, and Perry F. Renshaw. Hypobaric hypoxia induces depression-like behavior in female Sprague-Dawley rats, but not males. High Alt Med Biol 16:52–60, 2015—Rates of depression suicide are higher people living at altitude, those with chronic hypoxic disorders like asthma, obstructive pulmonary disorder (COPD), smoking. Living altitude exposes to hypobaric hypoxia, which can lower rat brain serotonin levels,...
Sheth, Chandni, Hendrik Ombach, Paul Olson, Perry F. Renshaw, and Shami Kanekar. Increased anxiety anhedonia in female rats following exposure to altitude. High Alt Med Biol. 19:81-90, 2018.-Anxiety disorders are chronic, highly prevalent conditions, often comorbid with depression. Both depression form major risk factors for suicide. Living at altitude is associated higher rates of suicide, leading us address whether may also be amplified Using a novel translational animal model, we...
Abstract One premise regarding the mechanism of injury‐evoked neuroregeneration is that injured cells induce release neurotrophic factors to trigger neurogenesis. Extracellular purine nucleotides exert multiple actions in central nervous system mediated via activation purinergic receptors. However, whether purinergics have a role olfactory neuroepithelium has not been investigated. Thus, we monitored ATP‐induced neuropeptide Y (NPY), increases neuroproliferation epithelium. To visualize NPY...
Background: Rates of major depressive disorder (MDD) increase with living at altitude. In our model, rats housed moderate altitude (in hypobaric hypoxia) exhibit increased depression-like behavior, altered brain serotonin and a lack antidepressant response to most selective reuptake inhibitors (SSRIs). A forebrain deficit in the bioenergetic marker creatine is noted people or MDD. Methods: Rats 4500 ft were given dietary monohydrate (CRMH, 4% w/w, 5 weeks) vs. un-supplemented diet, impact on...
Summary Insect and vertebrate eyes differ in their formation, cellular composition, neural connectivity, visual function. Despite this diversity, Drosophila atonal its Ortholog the eye, Ath5 , each regulate determination of first retinal neuron class—R8 photo‐receptors ganglion cells (RGCs)—in respective organisms. We have performed a cross‐species functional comparison these genes. In ato 1 mutant ectopic Xenopus ( Xath5 ) rescues photoreceptor cell development comparably with . contrast,...
Prescription opioid misuse and fatal overdoses have increased significantly over the last two decades. Living at altitude has been linked to greater reward benefits of other drugs abuse, living may also exacerbate respiratory depression use. Therefore, we examined relationships between altitude, prescription overdoses.
The signals for injury-evoked neuroregeneration are unknown; however previous studies implied that injured cells secrete neurotrophic factors which trigger neurogenesis. Extracellular purine nucleotides exert multiple actions in the CNS mediated via activation of purinergic (P2) receptors. Our work demonstrated ATP acts as a neuromodulator and stress signal olfactory epithelium (OE). To determine whether P2 receptor evokes factor secretion OE, we monitored release NPY, neuroproliferative...
Abstract In the adult spinal cord, immunocytochemical staining for NT75 is concentrated in nerve terminals superficial laminae of dorsal horn. Deeper horn contain moderate labeling, but ventral only sparsely stained. The origin containing was investigated with lesion techniques, colchicine treatment, and retrograde tracing combination staining. Primary afferent neurons express immunoreactivity account most dense part labeling deeper laminae. It found that corticospinal virtually all...