A5084233429- Platelet Disorders and Treatments
- Complement system in diseases
- Calcium signaling and nucleotide metabolism
- Ion Channels and Receptors
- Sulfur-Based Synthesis Techniques
- Catalytic C–H Functionalization Methods
- Synthesis and Catalytic Reactions
- Erythrocyte Function and Pathophysiology
- Blood Coagulation and Thrombosis Mechanisms
- Cardiac, Anesthesia and Surgical Outcomes
- Sepsis Diagnosis and Treatment
- Synthetic Organic Chemistry Methods
- biodegradable polymer synthesis and properties
- Neuropeptides and Animal Physiology
- Adenosine and Purinergic Signaling
- Cellular transport and secretion
- Renal Diseases and Glomerulopathies
- Blood properties and coagulation
- Organometallic Complex Synthesis and Catalysis
- Cell Adhesion Molecules Research
Institute of Molecular Biology
2021-2024
University of Münster
2019-2022
University of Toledo
2019
Max Planck Institute for Polymer Research
2016
University of Applied Sciences Mainz
2016
Abstract A new class of intermolecular olefin aminooxygenation reaction is described. This utilizes the classic halonium intermediate as a regio‐ and stereochemical template to accomplish selective oxyamination both activated unactivated alkenes. Notably, urea chemical feedstock can be directly introduced N O source simple iodide salt utilized catalyst. formal [3+2] cycloaddition process provides highly modular entry range useful heterocyclic products with excellent selectivity...
Rationale: Capillary leakage frequently occurs during sepsis and after major surgery is associated with microvascular dysfunction adverse outcome. Procalcitonin a well-established biomarker in inflammation without known impact on vascular integrity. Objectives: We determined how procalcitonin induces endothelial hyperpermeability targeting protects barrier Methods: In prospective observational clinical study, levels were assessed 50 patients who underwent cardiac correlated to postoperative...
Weibel Palade bodies (WPB) are lysosome-related secretory organelles of endothelial cells. Commonly known for their main cargo, the platelet and leukocyte receptors von-Willebrand factor (VWF) P-selectin, WPB play a crucial role in hemostasis inflammation. Here, authors identify glycerophosphodiester phosphodiesterase domain-containing protein 5 (GDPD5) as cargo show that GDPD5 is transported to following uptake from plasma membrane via an unique endocytic transport route. cleaves...
2-Cyclohexyl-2-oxo-1,3,2-dioxaphospholane (<sup>cy</sup>HexPPn), a new monomer for the anionic ring-opening polymerization to poly(ethylene alkyl phosphonate)s is presented.
Weibel-Palade bodies (WPB) are endothelial cell-specific storage granules that regulate vascular hemostasis by releasing the platelet adhesion receptor von Willebrand factor (VWF) following stimulation. Fusion of WPB with plasma membrane is accompanied formation actin rings or coats support expulsion large multimeric VWF fibers. However, factor(s) organizing these ring structures have remained elusive. We now identify actin-binding proteins Spire1 and Myosin Vc (MyoVc) as cytosolic factors...
Abstract A new class of intermolecular olefin aminooxygenation reaction is described. This utilizes the classic halonium intermediate as a regio‐ and stereochemical template to accomplish selective oxyamination both activated unactivated alkenes. Notably, urea chemical feedstock can be directly introduced N O source simple iodide salt utilized catalyst. formal [3+2] cycloaddition process provides highly modular entry range useful heterocyclic products with excellent selectivity...
Upon proinflammatory challenges, endothelial cell surface presentation of the leukocyte receptor P-selectin, together with stabilizing co-factor CD63, is needed for capture and mediated via demand-driven exocytosis from Weibel-Palade bodies that fuse plasma membrane. We report neutrophil recruitment to activated endothelium significantly reduced in mice deficient endolysosomal cation channel TPC2 human primary cells pharmacological block. observe less CD63 signal whole-mount stainings...
Weibel-Palade bodies (WPB) are elongated, rod-like secretory organelles unique to endothelial cells that store the pro-coagulant von-Willebrand factor (VWF) and undergo regulated exocytosis upon stimulation with Ca2+- or cAMP-raising agonists. We show here WPB preferentially initiate fusion plasma membrane at their tips identify synaptotagmin-like protein 2-a (Slp2-a) as a positive regulator of VWF secretion most likely mediating this topological selectivity. Following secretagogue...
Abstract In response to pro-inflammatory challenges including pathogenic attack and tissue damage, the endothelial cell surface is rearranged present leukocyte-engaging receptors. The initial contact needed for leukocyte tethering rolling mediated via adhesion demand-driven exocytosis of Weibel-Palade bodies (WPB) that contain receptor P-selectin together with stabilizing co-factor CD63. We found diminished expression endolysosomal non-selective cation channel TPC2 or inhibition...