A5057186282- Autophagy in Disease and Therapy
- Estrogen and related hormone effects
- Click Chemistry and Applications
- Cell death mechanisms and regulation
- Chemical Synthesis and Analysis
- Calcium signaling and nucleotide metabolism
- Bioactive Compounds and Antitumor Agents
- Computational Drug Discovery Methods
- bioluminescence and chemiluminescence research
- Pharmacogenetics and Drug Metabolism
- Music Therapy and Health
- Histone Deacetylase Inhibitors Research
- Neuroscience and Music Perception
- Cancer Cells and Metastasis
- Insurance, Mortality, Demography, Risk Management
- Health, Environment, Cognitive Aging
- Chromosomal and Genetic Variations
- demographic modeling and climate adaptation
- Nanoplatforms for cancer theranostics
- Adipose Tissue and Metabolism
- CRISPR and Genetic Engineering
- Sphingolipid Metabolism and Signaling
- Epigenetics and DNA Methylation
- Photoreceptor and optogenetics research
- Drug Transport and Resistance Mechanisms
University of California, Davis
2020-2024
UC Davis Comprehensive Cancer Center
2020-2024
Columbia University Irving Medical Center
2022
University of Hawaiʻi at Mānoa
2016-2021
Honolulu University
2021
Using the Drosophila melanogaster Hox gene Ultrabithorax (Ubx) as an example, we demonstrate use of three heterologous DNA-binding protein systems—LacI/LacO, ParB1/ParS1, and ParB2/ParS2—to label genomic loci in imaginal discs with insertion a small DNA tag. We compare each system, considering impact labeling regions (1) inside versus outside transcribed body (2) varying chromatin accessibility. value this system by interrogating relationship between expression level enhancer-promoter...
Derivatives of the potassium-sparing diuretic amiloride are preferentially cytotoxic toward tumor cells relative to normal cells, and have capacity target cell populations resistant currently employed therapeutic agents. However, a major barrier clinical translation amilorides is their modest potency, with estimated IC
Abstract Derivatives of the potassium-sparing diuretic amiloride are preferentially cytotoxic toward tumor cells relative to normal cells, and have capacity target cell populations resistant currently employed therapeutic agents. However, a major barrier clinical translation amilorides is their modest potency, with estimated IC 50 values in high micromolar range. Here we report synthesis ten novel derivatives characterization potency MCF7 (ER/PR-positive), SKBR3 (HER2-positive) MDA-MB-231...
Identification of multiple ligand binding sites in aromatase.
The resistance of cancer cell subpopulations, including stem (CSC) populations, to apoptosis-inducing chemotherapeutic agents is a key barrier improved outcomes for patients. cationic amphiphilic drug hexamethylene amiloride (HMA) has been previously demonstrated efficiently kill bulk breast cells independent tumor subtype or species but acts poorly toward non-transformed derived from multiple tissues. Here, we demonstrate that HMA similarly cytotoxic CSC-related subpopulations are resistant...
The increasing prevalence of deep learning-based machines in the daily life average people results a demand for research to be done on improving accuracy learning models. In response this need, paper aims explore effects changing parameters model, including neuron count, epoch batch size, and validation split prediction model. We used programming language Python, TensorFlow Pandas libraries, Keras application interface create 13 regression-based models, all but one, which was as standard,...
The resistance of cancer cell subpopulations, including stem (CSC) populations, to apoptosis-inducing chemotherapeutic agents is a key barrier improved outcomes for patients. cationic amphiphilic drug hexamethylene amiloride (HMA) has been previously demonstrated efficiently kill bulk breast cells independent tumor subtype or species, but acts poorly toward non-transformed derived from multiple tissues. Here we demonstrate that HMA similarly cytotoxic CSC-related subpopulations are resistant...
Abstract Aromatase (Cyp19) catalyzes the last biosynthetic step of estrogens in mammals and is a primary drug target for hormone-related breast cancer. However, treatment with aromatase inhibitors often associated adverse effects resistance. In this study, we used virtual screening targeting predicted cytochrome P450 reductase binding site on to discover four novel non-steroidal inhibitors. The have potencies comparable noncompetitive tamoxifen metabolite, endoxifen. Our two most potent...
Adolescents in the USA are experiencing increasing rates of depressive symptoms each year, resulting a variety emotional, social, neurological, and behavioral problems. Current traditional treatments limited their ability to reduce depression. In past few decades, music therapy has emerged as viable treatment for depression its comorbidities across various age groups demographics. Music is unique form clinical evidence-based characterized by relationship between therapist patient address...