A5068924391- Genomics and Chromatin Dynamics
- RNA Research and Splicing
- Gene Regulatory Network Analysis
- Theoretical and Computational Physics
- RNA and protein synthesis mechanisms
- Advanced Thermodynamics and Statistical Mechanics
- Nonlinear Dynamics and Pattern Formation
- Neural dynamics and brain function
- Bioinformatics and Genomic Networks
- History and Theory of Mathematics
- Complex Systems and Time Series Analysis
- stochastic dynamics and bifurcation
- Chromosomal and Genetic Variations
- Statistical Mechanics and Entropy
- Quantum chaos and dynamical systems
- Opinion Dynamics and Social Influence
- Chaos control and synchronization
- Stochastic processes and statistical mechanics
- Mathematics and Applications
- Complex Network Analysis Techniques
- DNA and Nucleic Acid Chemistry
- RNA modifications and cancer
- Material Dynamics and Properties
- Epigenetics and DNA Methylation
- Protein Structure and Dynamics
Laboratoire de Physique Théorique de la Matière Condensée
2016-2025
Sorbonne Université
2015-2025
Institut de Génétique Moléculaire de Montpellier
2015-2024
Centre National de la Recherche Scientifique
2014-2023
Université de Montpellier
2014-2023
Constructor University
2022
Institut de Génétique, Environnement et Protection des Plantes
2021
Université Paris Cité
2011-2017
Dynamique du noyau
2016
Institut des Hautes Études Scientifiques
2006-2014
Live-cell imaging has revealed unexpected features of gene expression. Here using improved single-molecule RNA microscopy, we show that synthesis HIV-1 is achieved by groups closely spaced polymerases, termed convoys, as opposed to single isolated enzymes. Convoys arise a Mediator-dependent reinitiation mechanism, which generates transient but rapid succession polymerases initiating and escaping the promoter. During elongation, are few hundred nucleotides, physical modelling suggests DNA...
Statistical entropy was introduced by Shannon as a basic concept in information theory measuring the average missing random source. Extended into an rate, it gives bounds coding and compression theorems. In this paper, I describe how statistical rate relate to other notions of that are relevant probability (entropy discrete distribution its unevenness), computer sciences (algorithmic complexity), ergodic dynamical systems (Kolmogorov–Sinai or metric entropy) physics (Boltzmann entropy)....
Epigenetics is essential in understanding the development, from a common undifferentiated cell, of different cell types that share same hereditary materials their genome. A meaningful decoration chemical marks on chromosomes selects genes to be expressed by directing differential folding genome nucleus. This article surveys plausible physical mechanisms involved setting up epigenetic and role expression.
While entropy per unit time is a meaningful index to quantify the dynamic features of experimental series, its estimation often hampered in practice by finite length data. We here investigate performance procedures, relying either on block entropies or Lempel-Ziv complexity, when only very short symbolic sequences are available. Heuristic analytical arguments point at influence temporal correlations bias and statistical fluctuations, put forward reduced effective sequence suitable for error...
The molecular support of genetic information, DNA, has to be packaged and organized inside the tiny volume nuclei, cells, or virus capsids, in an ordered dynamical way. Evolution favored different strategies kingdoms: a liquid crystal ordering mechanism prevails viruses; strong entanglement due supercoiling is main compacting strategy bacteria; building hierarchical tunable architecture mediated by DNA–protein interaction constitutes archaea eukaryotes. interplay between these however much...
Introduction: Production systems are bound to operate in stochastic conditions. Prominent sources of performance-reducing uncertainty constituted by machine failures, decision errors, and fluctuating supplies. This article offers a novel approach through modelling simulation nonlinear production systems. In particular, the authors consider where output is drastically reduced when resource input values reaches an upper threshold. Methods: The introduces minimal models such hreshold-impeded...
Abstract Motivation: Multidimensional scaling (MDS) is a well-known multivariate statistical analysis method used for dimensionality reduction and visualization of similarities dissimilarities in multidimensional data. The advantage MDS with respect to singular value decomposition (SVD) based methods such as principal component its superior fidelity representing the distance between different instances specially high-dimensional geometric objects. Here, we investigate importance choice...
Understanding the interplay of topology and dynamics excitable neural networks is one major challenges in computational neuroscience. Here we employ a simple deterministic model to explore how network-wide activation patterns are shaped by network architecture. Our observables co-activation patterns, together with average activity periodicities excitation density. main results are: (1) dependence correlation between adjacency matrix instantaneous (zero time delay) on global features...
This paper focuses on mechanical aspects of chromatin biological functioning. Within a basic geometric modeling the assembly, we give complete set elastic constants (twist and bend persistence lengths, stretch modulus twist-stretch coupling constant) so-called 30-nm fiber, in terms DNA properties fiber assembly. The computation naturally embeds within current analytical model known as "extensible wormlike rope," allowing straightforward prediction force-extension curves. We show that these...
The ectomycorrhizal (ECM) symbiosis connects mutualistic plants and fungal species into bipartite networks. While links between one focal ECM plant its symbionts have been widely documented, systemic views of networks are lacking, in particular, concerning the ability to mediate indirect ecological interactions (projected-ECM networks). We assembled a large dataset plant-fungi associations at level scale Corsica using molecular data unambiguously host-assigned records to: (i) examine...