A5048213454- Bone Metabolism and Diseases
- Bone health and treatments
- Cytokine Signaling Pathways and Interactions
- Ion Channels and Receptors
- Inflammatory mediators and NSAID effects
- Reproductive System and Pregnancy
- Immunotherapy and Immune Responses
- Immune Cell Function and Interaction
- Biomarkers in Disease Mechanisms
- Heat shock proteins research
- Photography and Visual Culture
- Cardiovascular, Neuropeptides, and Oxidative Stress Research
- Metabolism, Diabetes, and Cancer
- Calcium signaling and nucleotide metabolism
- Cancer, Hypoxia, and Metabolism
- Sphingolipid Metabolism and Signaling
- Rheumatoid Arthritis Research and Therapies
- Cancer-related Molecular Pathways
- Cancer Immunotherapy and Biomarkers
- Toxin Mechanisms and Immunotoxins
- Hematopoietic Stem Cell Transplantation
- Immune cells in cancer
- Dietary Effects on Health
- Cholesterol and Lipid Metabolism
- Macrophage Migration Inhibitory Factor
Bristol-Myers Squibb (United States)
2023
Yale University
2013-2021
University of Connecticut
2008-2011
UConn Health
2007-2009
Abstract Peroxisome proliferator-activated receptor (PPAR)γ is a nuclear hormone primarily characterized for its effect on insulin metabolism. PPARγ ligands, used to treat human type 2 diabetes, also down-regulate most immune system cells including APCs and pathogenic T cells. These effects putatively underlie the efficacy of ligands in treating animal models autoimmunity, leading projections therapeutic potential autoimmunity. However, relationship between CD4+CD25+ regulatory (Tregs) has...
Bone surfaces attract hematopoietic and nonhematopoietic cells, such as osteoclasts (OCs) osteoblasts (OBs), are targeted by bone metastatic cancers. However, the mechanisms guiding cells toward essentially unknown. Here, we show that Gαi protein–coupled receptor (GPCR) EBI2 is expressed in mouse monocyte/OC precursors (OCPs) its oxysterol ligand 7α,25-dihydroxycholesterol (7α,25-OHC) secreted abundantly OBs. Using vitro time-lapse microscopy intravital two-photon microscopy, enhances...
Vanilloid receptor 1 (VR1) is expressed on immune cells as well sensory neurons. Here we report that VR1 can regulate immunological events in the gut response to its ligand Capsaicin (CP), a nutritional factor, pungent component of chili peppers. Oral administration CP attenuates proliferation and activation autoreactive T pancreatic lymph nodes (PLNs) but not other nodes, protects mice from development type diabetes (T1D). This general phenomenon restricted one particular strain mice....
ABSTRACT Rac1 and Rac2 are thought to have important roles in osteoclasts. Therefore, mice with deletion of both mature osteoclasts (DKO) were generated by crossing Rac1flox/flox expressing Cre the cathepsin K locus then mating these animals Rac2-/- mice. DKO had markedly impaired tooth eruption. Bone mineral density (BMD) was increased 21% 33% 4- 6-week-old at all sites when measured dual-energy X-ray absorptiometry (DXA) serum cross-linked C-telopeptide (CTx) reduced 52%. The amount...
CaMKK2 signals through AMPK-dependent and AMPK-independent pathways to trigger cellular outputs including proliferation, differentiation, migration, resulting in changes metabolism, bone mass accrual, neuronal function, hematopoiesis, immunity. CAMKK2 is upregulated tumors hepatocellular carcinoma, prostate, breast, gastric cancer, genetic deletion myeloid cells results increased antitumor immunity several syngeneic models. Validation of the biological roles has relied on or small molecule...
Abstract BACKGROUND Prostate cancer promotes the development of T cell tolerance towards prostatic antigens, potentially limiting efficacy prostate vaccines targeting these antigens. Here, we sought to determine stage disease progression when develops, as well role steady state dendritic cells (DC) and CD4 + CD25 regulatory (Tregs) in programming tolerance. METHODS The response naïve HA‐specific were analyzed following adoptive transfer into Pro‐HA × TRAMP transgenic mice harboring...
The receptor for Colony Stimulating Factor 1 (CSF1), c-fms, is highly expressed on mature osteoclasts suggesting a role this cytokine in regulating the function of these cells. Consistent with idea, vitro studies have documented variety effects CSF1 osteoclasts. To better define cells, we conditionally deleted c-fms (c-fms-OC -/- ) by crossing flox/flox mice expressing Cre under control cathepsin K promoter. c-fms-OC were normal weight and had tooth eruption. However, when quantified DXA,...
Abstract Osteoclasts (OCs) are bone-lining cells derived from the fusion of monocytic precursors. Their exclusive positioning in contact with bone enables OC differentiation and remodeling outgrowth. However, guidance cues that osteoclast precursors (OCP) follow for at surface remain poorly characterized. We demonstrate EBI2 (Gpr183) was abundantly expressed OCPs, autocrine signaling necessary into mature osteoclasts vitro. The expression its ligands suggested regulates OCP motility. Time...
Abstract Sensory nerve fibers innervating the pancreas play a critical role in etiology of autoimmune diabetes. These sensory neurons express nonselective cation channel vanilloid receptor 1 (VR1) which has been identified as for acid, temperatures > 43°C and Capsaicin (CP), principal pungent ingredient chili peppers. We have reported that dendritic cells (DCs), key cell type immune responses, CP, engagement this powerful consequences. However very little is known about function VR1...
Capsaicin (CP) is the pungent component of chili peppers. We have observed previously that dendritic cells (DCs), a key cell type in immune responses, receptor for CP, and engagement this has powerful consequences. As CP can be used as adjuvant enhancement an response, we tested its immunomodulatory activity by oral administration treatment Type 1 diabetes (T1D) non‐obese diabetic (NOD) mice. Here demonstrate delays onset NOD mice dose dependent manner adoptive transfer splenocytes from...
Abstract The immunogenicity of heat shock protein-peptide complexes (HSPs) against tumors and pathogens is initiated when the HSP engages its receptors, CD91 maybe others, on antigen presenting cells (APCs). This allows APCs to obtain in form peptides, acquire signals that indicate for them mature, express co-stimulation migrate (1). However, high doses HSPs tend negate ongoing T cell responses (2), an effect shown involve generation a CD4+ suppressor response (3). immune suppression has...