Background: Premarital screening (PMS) is a nationwide program that helps high-risk individuals make decisions to avoid genetic and sexually transmitted diseases from spreading their spouse or future offspring. This study examined the knowledge attitudes towards inherited hemoglobinopathies in PMS among people of Northern Border Region Saudi Arabia relationship various sociodemographic factors. Methods: A cross-sectional was undertaken region January March 2024. Data were gathered via...

Leprosy and tuberculosis caused by Mycobacterium leprae tuberculosis, respectively, are chronic infections with significant public health implications. While leprosy affects the skin peripheral nerves primarily targets lungs, both diseases involve systemic immune responses. This study integrates transcriptomic analysis cheminformatics molecular dynamics simulations to identify mechanisms potential therapeutic targets. Transcriptomic datasets were analyzed dysregulated genes pathways. Pathway...

In a 1 year period (1993) 332 facial fractures were treated in Cork Regional Hospital. Of these 110 (33%) sports related. Males accounted for 94.5% of patients and 77% aged below 30 years. Nasal the most common seen (56%). Almost half (49%) related occurred while playing Gaelic games. The incidence hurling has been more than halved over last 20 Seventy eight percent required operative treatment.

Objective: Assessing the efficacy of a polyhydrated ionogen impregnated dressing in treatment recalcitrant diabetic foot ulcers.Summary Background Data: Diabetic Foot Ulcers (DFU) continue to present formidable challenge terms morbidity and health care costs. Increasing evidence ascertains important role Matrix MetalloProteinases (MMPs) their tissue inhibitors, TIMPs, wound healing. Imbalance MMPs DFU microenvironment has been associated with poor Current research is directed towards...

Background. Multiple studies have reported that cannabis administration in multiple sclerosis patients is associated with decreased symptom severity. This study was conducted to evaluate the prevalence of abuse cases and effect on serum cytokines such cases. Patients Methods. A total 150 along healthy controls were included during period. All subjected history taking, neurological examination, routine investigations. Cases asked about intake which confirmed by a urine test. Serum including...

Abstract Background Atherosclerosis is a systemic disease affecting the coronary, carotid, and lower limb arteries. Cerebrovascular accidents ischemia are devastating postoperative complications. We aimed to evaluate role of non-selective routine arterial duplex scanning in patients undergoing coronary artery bypass grafting (CABG). Methods This non-randomized clinical trial included 360 scheduled for elective isolated CABG who were divided into two groups: low-risk ( n = 180) high-risk...

Background: Minimally invasive valve replacement is increasingly accepted among surgeons and patients alike. Ministernotomy minithoracotomy are the most used incisions in minimally aortic replacement. The superiority of one incision over other still debatable with a few centers having opportunity to compare them head-to-head. Methods: A retrospective analysis 260 patients, who underwent mini AVR, 132 ministernotomy group 128 group. Operative details, mortality, wound cosmetics, postoperative...

BACKGROUND: Breast cancer is a common women's disease. Usually, oestrogen blamed in the aetiology and correlated with prognosis; however, androgens are recently raising concern about its role breast treatment prognosis. METHODS: In this study we retrieved archival paraffin blocks of patients stained it for androgen. Thereafter, compared clinico-epidemiologic parameters, histopathology, neoadjuvant response recurrence rate pattern among without androgen receptor (AR) expression. RESULTS:...

There are many arterial cannulation sites to establish cardiopulmonary bypass (CPB). Each site has its advantages and disadvantages. Organ malperfusion especially the cerebral during CPB is most critical outcome in comparing different sites. We aimed evaluate safety efficacy of axillary femoral various situations. This retrospective observational study, included 75 patients underwent redo valve surgery or denovo thoracic aorta surgery. Patients were reviewed terms organ namely brain kidney;...

Tetralogy of Fallot is the most common cyanotic congenital heart defect. Borderline pulmonary anatomy has been associated with a higher risk mortality and morbidity. Strategies to manage this condition-namely, single- or multistage repair-have long debated.The overall outcomes patients tetralogy borderline arteries (McGoon ratio 1.3 1.7) regard need for single-stage repair outcome each surgical management were evaluated.A retrospective, nonrandomized comparative study designed evaluate...

Minimally invasive aortic surgery is growing in popularity among surgeons. Although many clinical reports have proven both the safety and efficacy from a surgical point of view, there are few data regarding its impact on patients' quality life whether difference between ministernotomy minithoracotomy patient perspective.This prospective, questionnaire-based, nonrandomized study included 189 patients who underwent valve replacement via minimally incision May 2014 December 2020 completed at...

There are many factors that determine the best neurocognitive outcome following cardiac surgery. Optimum oxygen delivery to tissues has always been goal optimum perfusion. Some patients may exhibit impairments in early postoperative period; could be easily missed clinically as they not associated with radiographic evidence of structural brain damage. At this study we aimed correlate lowest levels incidence impairment period by Folstein test. A non-randomized, prospective pilot was designed...

Background: Proper visualization has always been the cornerstone for conducting proper cardiac interventions. Although many incisions have described mitral valve exposure, feasibility of some comes at expense exposure. When it to a small left atrium, larger may venture into critically situated structures, creating heavy toll increased morbidity and mortality. We aim evaluate safety efficacy superior atrium approach interventions atrial mass resection, particularly in atrium.Methods: present...

Among the most emotionally distressing experiences in cardiac surgery is removal of mediastinal drains. The study compared between two commonly used methods for pain control during procedure chest drain removal. We either systemic administration IV morphine or local infiltration Bupivacaine as a mode analgesia. Our goal was to provide effective analgesia and patient comfort, while keeping high standards safety. A prospective, randomized, single blinded observational conducted institution;...

Background: Left ventricular ejection fraction is an independent determinant of the outcome coronary artery bypass surgery. Low preoperative requires special care in terms pharmacological and mechanical inotropic support. Adrenaline most widely used drug, while levosimendan a relatively new drug field cardiac In this study, we aimed to evaluate relative efficacy low patients undergoing grafting (CABG). Methods: A retrospective comparative study was performed with 63 who underwent isolated...

Aortic root abscess complicated by infective endocarditis of a mechanical prosthetic valve is associated with morbidity and death. We retrospectively report our experience valve-sparing technique for managing this condition. From October 2014 through November 2017, 41 patients at center underwent surgery aortic valve. Twenty (48.7%) met prespecified criteria use after careful assessment the surrounding tissues. Our involved draining abscess, aggressively débriding all infected necrotic...

Background: Atrial fibrillation (AF) is the most common form of dysrhythmia observed in clinical field, causing multiple morbidities, such as thromboembolic complications. Hence, maintenance sinus rhythm superior to rate control. This study tests efficacy single- and low-dose amiodarone on persistence AF after surgery before transfer intensive care unit. Methods: A double-blinded, randomized controlled trial assessed 113 patients who underwent mitral valve with preoperative chronic AF....

Background Myocardial hypertrophy is a common pathologic finding in the natural history of severe aortic stenosis. A hypertrophied myocardium predisposes patient to decreased tolerance ischemia and increased reperfusion injury, myocardial protection utmost importance patients undergoing valve replacement (AVR) for techniques during cardiac arrest have been extensively investigated clinical setting coronary revascularization. However, fewer studies carried out on affected by left ventricular...

Ventricular fibrillation occurs commonly after aortic cross clamp in patients undergoing valve replacement for severe stenosis. Amiodarone is a class III antiarrhythmic drug that can be used as prophylactic measure to prevent reperfusion ventricular increases myocardial oxygen demand and hence damage. A prospective, randomized, triple blinded study conducted single institution, Cardio-thoracic Academy, Ain –Shams University, Cairo, Egypt.120 with AS enrolled elective replacement. 60 received...

Background: Obesity has a great impact on overall mortality and morbidity in cardiac surgery. The magnitude of obesity is defined by means body mass index (BMI). At this study we aim to correlate between grade BMI postoperative complications patients undergoing coronary revascularization. Methods: A prospective observational was conducted Ain Shams University hospitals the National Heart Institute Egypt. 98 with multi-vessel CAD candidate for CABG were included divided into two groups Group...