A5025146578- Glioma Diagnosis and Treatment
- Immunotherapy and Immune Responses
- Neuroblastoma Research and Treatments
- MicroRNA in disease regulation
- Nonmelanoma Skin Cancer Studies
- Cancer Genomics and Diagnostics
- Epigenetics and DNA Methylation
- Oral and Maxillofacial Pathology
- COVID-19 and healthcare impacts
- Neurological disorders and treatments
- Diabetes and associated disorders
- Genetics and Neurodevelopmental Disorders
- Anorectal Disease Treatments and Outcomes
- Legionella and Acanthamoeba research
- Advanced X-ray and CT Imaging
- Sarcoidosis and Beryllium Toxicity Research
- Mitochondrial Function and Pathology
- COVID-19 Clinical Research Studies
- Circular RNAs in diseases
- Biomarkers in Disease Mechanisms
- CAR-T cell therapy research
- Diverticular Disease and Complications
- Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities
- Herpesvirus Infections and Treatments
- Soft tissue tumor case studies
Northern Border University
2024-2025
Université Grenoble Alpes
2021
Centre Hospitalier Universitaire de Grenoble
2014-2020
Hôpital Farhat Hached
2012-2018
Faculté de médecine de Tunis
2010
Tunis University
2008
Background: Premarital screening (PMS) is a nationwide program that helps high-risk individuals make decisions to avoid genetic and sexually transmitted diseases from spreading their spouse or future offspring. This study examined the knowledge attitudes towards inherited hemoglobinopathies in PMS among people of Northern Border Region Saudi Arabia relationship various sociodemographic factors. Methods: A cross-sectional was undertaken region January March 2024. Data were gathered via...
Steroid 11β-hydroxylase deficiency is the second most common cause of congenital adrenal hyperplasia, resulting in virilization, glucocorticoid and hypertension. The enzyme encoded by CYP11B1 gene mutations this are responsible for disease. aim study was to characterize determine their frequencies a cohort Tunisian patients. molecular genetic analysis performed direct nucleotide sequencing 15 unrelated patients suffering from classical deficiency. Only two were detected homozygous state all...
Background: Glioma is a heterogeneous central nervous system (CNS) tumor group that encompasses different histological subtypes with high variability in prognosis. The lesions account for almost 80% of primary malignant brain tumors. aim this study to extend our understanding the glioma epidemiology Tunisian region. Materials and Methods: We analyzed 393 gliomas recorded cancer registry Tunisia from 1993 2012. Crude incidence rates (CR) world age-standardized (ASR) were estimated using...
Background: The meningeal hemangiopericytoma (MHPC) is a vascular tumor arising from pericytes. Most intracranial MHPCs resemble meningiomas (MNGs) in their clinical presentation and histological features may therefore be misdiagnosed, despite important differences prognosis. Materials Methods: We report 8 cases of MHPC 5 MNG collected 2007 to 2011 the Neuro-Surgery Histopathology departments. All 13 samples were re reviewed by two independent pathologists investigated immunohistochemistry...
Beckwith-Wiedemann syndrome has a wide spectrum of complications such as embryonal tumors, namely adrenocortical tumor. Tumor predisposition is one the most challenging manifestations this syndrome. A 45-day old female with family history tumor presented The case raised suspicion hereditary syndrome, therefore molecular analysis was undertaken. results revealed partial KCNQ1OT1 hypomethylation in infant's blood DNA which associated complete loss methylation tissue. It unique for familial...
Huntington’s disease (HD) is an autosomal dominant neurodegenerative disorder. The causative mutation expansion of more than 36 CAG repeats in the first exon IT15 gene. Many studies have shown that interacts with several modifier genes to regulate age at onset (AO) HD. Our study aims investigate implication and 9 modifiers variance 15 HD Tunisian patients establish correlation between these AO this disease. Despite small number studied patients, report consists North African Huntington...
Recent molecular profiling studies of paediatric high grade (pHGG) and diffuse intrinsic pontine glioma (DIPG) have refined these tumours into age- location-based subgroups driven by unique genetic epigenetic alterations, however individual are underpowered to investigate subgroup-specific events. We retrieved publicly available genome-wide data from ∼560 pHGG/DIPG samples combined this with ∼140 unpublished cases including young adults up the age 30 years. integrated multiple array-based...