A5074039333- Neuroscience and Neuropharmacology Research
- Gut microbiota and health
- Neural dynamics and brain function
- Tryptophan and brain disorders
- Photoreceptor and optogenetics research
- Memory and Neural Mechanisms
- GABA and Rice Research
- Mast cells and histamine
- Phosphodiesterase function and regulation
- Cholinesterase and Neurodegenerative Diseases
- Metabolomics and Mass Spectrometry Studies
- Neuroscience and Neural Engineering
- Genetics and Neurodevelopmental Disorders
McGovern Institute for Brain Research
2021-2022
Massachusetts Institute of Technology
2021-2022
Qingdao University
2021
West Virginia University
2021
Significance Anterior thalamus exhibits significant functional changes with increasing age. While it has been associated cognitive functions, the specific circuitry relevant for working memory remains unknown. The significance of this study is threefold: First, anteroventral subdivision anterior thalamic nuclei necessary maintenance; second, aged mice showed a decrease in excitability neurons, which correlated impairment; and third, activating neurons was sufficient to improve their memory.
Background: Fasudil, a Rho kinase inhibitor, exerts therapeutic effects in mouse model of Alzheimer's disease (AD), chronic neurodegenerative with progressive loss memory. However, the mechanisms remain unclear. In addition, gut microbiota and its metabolites have been implicated AD. Methods: We examined effect fasudil on learning memory using Morris water-maze (MWM) test APPswe/PSEN1dE9 transgenic (APP/PS1) mice (8 months old) treated (i.p.) (25 mg/kg/day; ADF) or saline (ADNS) age-...
Abstract Background: Fasudil, a Rho kinase inhibitor, exerts therapeutic effects in the mouse model of Alzheimer’s disease (AD), chronic neurodegenerative with progressive loss memory. However, mechanisms remain unclear. In addition, gut microbiota and its metabolites have been implicated AD. Methods: Here, we examined effect fasudil on learning memory using Morris water-maze (MWM) test APPswe/PSEN1dE9 transgenic (APP/PS1) mice (8 months old) treated (i.p.) (25 mg/kg/day; ADF) or saline...