A5069328671- DNA and Nucleic Acid Chemistry
- Synthesis and Biological Evaluation
- Berberine and alkaloids research
- Synthesis and bioactivity of alkaloids
- Advanced biosensing and bioanalysis techniques
- Synthesis and Characterization of Heterocyclic Compounds
- Analytical Chemistry and Chromatography
- Nanoparticles: synthesis and applications
- Drug Transport and Resistance Mechanisms
- Biochemical effects in animals
- RNA Interference and Gene Delivery
- Natural Antidiabetic Agents Studies
- Graphene and Nanomaterials Applications
- Protein Interaction Studies and Fluorescence Analysis
- Cancer therapeutics and mechanisms
- Synthesis and biological activity
- Click Chemistry and Applications
- Advanced Glycation End Products research
- Microplastics and Plastic Pollution
University of Calcutta
2023-2025
In this investigation, different multispectroscopic analytical techniques have been used to explore the interaction between polyethylene microplastics (PE-MPs) and human hemoglobin (HHb), an oxygen carrier in blood circulatory system. Ultraviolet–visible absorption studies demonstrated that HHb molecules may interact with PE-MPs, thermal melting indicated PE-MPs a stabilizing effect on HHb. Further circular dichroism Fourier transform infrared spectroscopic revealed distinct changes HHb's...
I-motif (iM) DNA structures are dynamic cytosine-rich secondary that increasingly recognized for their roles in transcriptional regulation, genomic stability, and potential as therapeutic targets cancer. Despite significance, the development of selective small-molecule probes iM remains a challenge. In this study, series iminocoumarin-benzothaizole derivatives were designed, synthesized, subjected to extensive screening explore interactions with various constructs, including H-Telo, HRAS1,...
Harmaline and harmine are two structurally similar β-carboline alkaloids with several therapeutic activities, such as anti-inflammatory, antioxidant, neuroprotective, nephroprotective, antidiabetic, antitumor activities. It has been previously reported that the interaction between harmaline hemoglobin (Hb) is weak in buffer media compared to harmine. Crowding agents induce a molecular crowding environment ex vivo condition, which almost intracellular environment. In this present study, we...
Harmine and harmaline are two structurally similar heterocyclic β-carboline plant alkaloids with various therapeutic properties, having a slight structural difference in the C3=C4 double bond. In present study, we have reported nature of interaction between hemoglobin (Hb) harmine by employing several multispectroscopic, calorimetric, molecular docking approaches. Fluorescence spectroscopic studies shown stronger Hb compared to that almost harmaline. Steady-state anisotropy experiments...
Abstract G‐quadruplex DNA (GQ‐DNA) represents one of the most significant non‐canonical nucleic acid configurations. GQ‐DNA producing sequences are found in different important genomic areas, including promoter islands numerous oncogenes and human telomere regions. Therefore, is a key target for anticancer medicines. has highly variable structure, it critical to develop ligand molecules that selectively certain quadruplex sequences. Natural products such as pyridocarbazole alkaloids have...
Abstract Harmine and harmaline are two structurally similar β-carboline plant alkaloids with various therapeutic properties, having difference in C3 = C4 double bond only. Nature of the interaction between hemoglobin (Hb) harmine was investigated this study by employing different spectroscopic methods molecular modeling. The spectrum Hb showed hypochromic changes presence both but efficiencies. fluorescence quenching occurred indicating stronger interation Hb. Stoichiometry revealed that...