A5013043801- DNA and Nucleic Acid Chemistry
- Microplastics and Plastic Pollution
- RNA Interference and Gene Delivery
- Advanced biosensing and bioanalysis techniques
- biodegradable polymer synthesis and properties
- RNA and protein synthesis mechanisms
- Nanoparticles: synthesis and applications
- Drug Transport and Resistance Mechanisms
- Healthcare and Environmental Waste Management
- Synthesis and Biological Evaluation
- Chronic Myeloid Leukemia Treatments
- Advanced Glycation End Products research
- Synthesis and bioactivity of alkaloids
- Protein Interaction Studies and Fluorescence Analysis
- Recycling and Waste Management Techniques
- Synthesis and biological activity
- Graphene and Nanomaterials Applications
- Cancer therapeutics and mechanisms
- Natural Antidiabetic Agents Studies
- Berberine and alkaloids research
- CRISPR and Genetic Engineering
- Parkinson's Disease Mechanisms and Treatments
- Biochemical effects in animals
- Analytical Chemistry and Chromatography
- Biosensors and Analytical Detection
Sri Balaji Vidyapeeth University
2025
I-Motif (iM) DNA structures represent among the most significant noncanonical nucleic acid configurations. iM-forming sequences are found in an array of vital genomic locations and particularly frequent promoter islands various oncogenes. Thus, iM is a crucial candidate for anticancer medicines; therefore, binding interactions between small molecular ligands, such as flavonoids, critically important. Extensive sets spectroscopic strategies thermodynamic analysis were utilized present...
In this investigation, different multispectroscopic analytical techniques have been used to explore the interaction between polyethylene microplastics (PE-MPs) and human hemoglobin (HHb), an oxygen carrier in blood circulatory system. Ultraviolet–visible absorption studies demonstrated that HHb molecules may interact with PE-MPs, thermal melting indicated PE-MPs a stabilizing effect on HHb. Further circular dichroism Fourier transform infrared spectroscopic revealed distinct changes HHb's...
Aggregation of human α-synuclein protein is regarded to be a key stage in the etiology Parkinson's disease and numerous other neurodegenerative illnesses. Microplastics pollution can potential agent promote various disorders. In this study, we have employed multispectroscopic analytical methods investigate binding interactions between polyethylene (PE-MPs), polyvinyl chloride (PVC-MPs), polystyrene (PS-MPs) microplastics, protein. Spectroscopic investigations using UV-vis absorption,...
The widespread contamination of the environment by microplastics (MPs), particularly polystyrene (PS) and polyethylene (PE), poses significant ecological health concerns. While much attention has been given to physical impact MPs, their molecular interactions, with genetic material, remain largely unexplored. This study examines how PS PE MPs influence structure stability human alternative i-motif (iM) DNA, which plays a key role in regulating gene expression maintaining genomic integrity....
Research on the interactions of naturally existing flavonoids with various noncanonical DNA such as i-motif (IM) structures is helpful in comprehending molecular basis binding mode well providing future direction for application and invention novel effective therapeutic drugs. IM have been identified prospective anticancer targets, are smaller molecules a variety health-promoting attributes, including activities. The extensive investigation comprising series techniques reveals contrasting...
Harmaline and harmine are two structurally similar β-carboline alkaloids with several therapeutic activities, such as anti-inflammatory, antioxidant, neuroprotective, nephroprotective, antidiabetic, antitumor activities. It has been previously reported that the interaction between harmaline hemoglobin (Hb) is weak in buffer media compared to harmine. Crowding agents induce a molecular crowding environment ex vivo condition, which almost intracellular environment. In this present study, we...
Harmine and harmaline are two structurally similar heterocyclic β-carboline plant alkaloids with various therapeutic properties, having a slight structural difference in the C3=C4 double bond. In present study, we have reported nature of interaction between hemoglobin (Hb) harmine by employing several multispectroscopic, calorimetric, molecular docking approaches. Fluorescence spectroscopic studies shown stronger Hb compared to that almost harmaline. Steady-state anisotropy experiments...
Abstract Cytosine‐rich i‐motif (iM) DNA tetraplexes can influence oncogenic transcription and developing phytomedicines for iMs is a viable approach cancer other disease treatments. Although natural compounds have been studied as iM binding ligands anticancer drug discovery, research on the structure‐interaction link between ligand, like of noncoplanar configurations iM‐ligand binding, rarely explored. Naringenin (NAR) gained attention their potential medicinal properties including high...