A5018334944- X-ray Diffraction in Crystallography
- Crystallization and Solubility Studies
- Crystallography and molecular interactions
- Oxidative Organic Chemistry Reactions
- Marine Sponges and Natural Products
- Synthesis of Tetrazole Derivatives
- Protein Kinase Regulation and GTPase Signaling
- Melanoma and MAPK Pathways
- Catalytic C–H Functionalization Methods
- Peroxisome Proliferator-Activated Receptors
- Chemical Synthesis and Reactions
- Open Education and E-Learning
- Synthetic Organic Chemistry Methods
- Peptidase Inhibition and Analysis
- Higher Education Learning Practices
- Glycosylation and Glycoproteins Research
- Collaboration in agile enterprises
- Analytical Chemistry and Sensors
- Synthesis and Catalytic Reactions
- Porphyrin and Phthalocyanine Chemistry
- Various Chemistry Research Topics
- Sulfur-Based Synthesis Techniques
Horizons Clinical Research Center
2024
University of Strathclyde
2001-2020
Significance S-acylation, the attachment of different fatty acids onto cysteine residues, regulates activity a diverse array cellular proteins. This reversible posttranslational modification is essential for normal physiology, and defects are linked to human disease. S-acylation catalyzed by large family zDHHC S-acyltransferases that use pool acyl-CoAs as substrates. Using chemically synthesized probes, we show individual enzymes have marked differences in acid selectivity identify...
Activating mutations of Ras are one the most prevalent drivers cancer and often associated with poor clinical outcomes. Despite FDA approval for two irreversible inhibitors that target inactive state KRasG12C, significant unmet need still exists, susceptibility non-G12C mutants to inactive-state inhibition remains unclear. Here we report discovery a novel series reversible bind in an enlarged version switch I-II pocket nanomolar affinities. Dependent on chemotype these can either...
Malonoyl peroxide 1, prepared in a single step from the commercially available diacid, is an effective reagent for anti-dihydroxylation of alkenes. Reaction 1 with alkene presence acetic acid at 40 °C followed by alkaline hydrolysis leads to corresponding diol (35–92%) up 13:1 anti-selectivity. A mechanism consistent experimental findings proposed that accounts selectivity observed.
Treatment of homoallylic N-tosyl amines or allylic hydroxylamines with 1.5 equiv a malonoyl peroxide provides stereoselective method to access functionalized pyrrolidines and isoxazolidines. This metal free alkene oxyamination proceeds in 50-85% yield up 13:1 trans-selectivity. In addition, the relative stereochemistry oxygen nitrogen substituents can be inverted through an oxidation/reduction sequence inverting starting alkene. Mechanistic investigations show higher reactivity for hydroxyl...
Activating mutations of Ras are one the most prevalent drivers cancer and often associated with poor clinical outcomes. Despite FDA approval for two irreversible inhibitors that target inactive state KRasG12C, significant unmet need still exists, susceptibility non-G12C mutants to inactive-state inhibition remains unclear. Here we report discovery a novel series reversible bind in an enlarged version switch I-II pocket nanomolar affinities. Dependent on chemotype these can either...
Activating mutations of Ras are one the most prevalent drivers cancer and often associated with poor clinical outcomes. Despite FDA approval for two irreversible inhibitors that target inactive state KRasG12C, significant unmet need still exists, susceptibility non-G12C mutants to inactive-state inhibition remains unclear. Here we report discovery a novel series reversible bind in an enlarged version switch I-II pocket nanomolar affinities. Dependent on chemotype these can either...
Abstract (E)‐Stilbene and (E)‐β‐methylstyrene derivatives as well various indene 1,2‐dihydronaphthalene are efficiently dihydroxylated to form mixtures of the corresponding syn‐ anti‐diols, which separated furnish anti‐diols in moderate high yields.
Abstract VIDEEO which is an acronym of VIrtual Development Enterprise for EurOpe a web-based environment supports both students and tutors in the creation execution multidisciplinary, distributed, product development projects. One main aims to provide teaching learning provides appropriate balance between technical vocational study. The project was funded by SOCRATES completed team partners from eight european institutions. objective this paper overview lifecycle through evaluation usage.